Effect of peppermint oil and caraway oil on gastrointestinal motility in healthy volunteers: a pharmacodynamic study using simultaneous determination of gastric and gall-bladder emptying and orocaecal transit time

2003 ◽  
Vol 17 (3) ◽  
pp. 445-451 ◽  
Author(s):  
K. J. Goerg ◽  
TH. Spilker
Keyword(s):  
Gall Bladder ◽  
Healthy Volunteers ◽  
Simultaneous Determination ◽  
Transit Time ◽  
Gastrointestinal Motility ◽  
Peppermint Oil ◽  
Bladder Emptying ◽  
Pharmacodynamic Study ◽  
Orocaecal Transit Time

An integrated strategy using LC-MS/MS combined with in vivo microdialysis for simultaneous determination of lignans of Schisandra chinensis (Turcz.) Baill. Fructus and endogenous neurotransmitters: Application to pharmacokinetic and pharmacodynamic study

2021 ◽  
Author(s):  
Jun Fu ◽  
Hongxu Zhang ◽  
Shu Liu ◽  
Jiajie Wu ◽  
Yuying Zhang ◽  
...  
Keyword(s):  
Simultaneous Determination ◽  
Daily Life ◽  
In Vivo Microdialysis ◽  
Schisandra Chinensis ◽  
Ripe Fruit ◽  
Integrated Strategy ◽  
Pharmacological Studies ◽  
Pharmacodynamic Study

Schisandra chinensis (Turcz.) Baill Fructus (SCF) is the ripe fruit of Schisandra chinensis (Turcz.) Baill, is often used as a neuroprotective drink in daily life. Modern pharmacological studies have shown...

scholarly journals Effect of intravenous amino acids on interdigestive antroduodenal motility and small bowel transit time

Gut ◽  
1999 ◽  
Vol 44 (2) ◽  
pp. 240-245 ◽  
Author(s):  
H A J Gielkens ◽  
A van den Biggelaar ◽  
J Vecht ◽  
W Onkenhout ◽  
C B H W Lamers ◽  
...  
Keyword(s):  
Amino Acids ◽  
Gall Bladder ◽  
Healthy Volunteers ◽  
Transit Time ◽  
Phase Ii ◽  
Cycle Length ◽  
Phase Iii ◽  
Saline Control ◽  
High Dose ◽  
Antroduodenal Motility

BackgroundPatients on total parenteral nutrition have an increased risk of developing gallstones because of gall bladder hypomotility. High dose amino acids may prevent biliary stasis by stimulating gall bladder emptying.AimsTo investigate whether intravenous amino acids also influence antroduodenal motility.MethodsEight healthy volunteers received, on three separate occasions, intravenous saline (control), low dose amino acids (LDA), or high dose amino acids (HDA). Antroduodenal motility was recorded by perfusion manometry and duodenocaecal transit time (DCTT) using the lactulose breath hydrogen test.ResultsDCTT was significantly prolonged during LDA and HDA treatment compared with control. The interdigestive motor pattern was maintained and migrating motor complex (MMC) cycle length was significantly reduced during HDA compared with control and LDA due to a significant reduction in phase II duration. Significantly fewer phase IIIs originated in the gastric antrum during LDA and HDA compared with control. Duodenal phase II motility index was significantly reduced during HDA, but not during LDA, compared with control.ConclusionsSeparate intravenous infusion of high doses of amino acids in healthy volunteers: (1) modulates interdigestive antroduodenal motility; (2) shortens MMC cycle length due to a reduced duration of phase II with a lower contractile incidence both in the antrum and duodenum (phase I remains unchanged whereas the effect on phase III is diverse: in the antrum phase III is suppressed and in the duodenum the frequency is increased); and (3) prolongs interdigestive DCTT.

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