Effect of barrier perturbation on cutaneous salicylic acid penetration in human skin: in vivo pharmacokinetics using microdialysis and non-invasive quantification of barrier function

Abstract Structural and chemical alterations in living tissue are reflected in electrical impedance changes. However, due to the complexity of skin structure, the relation between electrical parameters and physiological/pathological conditions is difficult to establish. The impedance dispersion reflects the clinical status of the examined skin tissue and, therefore, it is frequently used in a non-invasive evaluation of exposing skin to various factors. The method has been used to assess the effect of the fish collagen on the skin of patients suffering from the leg ulcer. Therefore, from a number of different approaches to skin electrical impedance dispersion, the one considered to be safe was selected and applied. This paper presents a short review of different technical approaches to in vivo electrical impedance measurements, as well as an analysis of the results and the effect of fish collagen locally administered on human skin.

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In vivo multiphoton imaging for non‐invasive time course assessment of retinoids effects on human skin

Skin Research and Technology ◽

10.1111/srt.12877 ◽

2020 ◽

Vol 26 (6) ◽

pp. 794-803

Author(s):

Emmanuelle Tancrède‐Bohin ◽

Thérèse Baldeweck ◽

Sébastien Brizion ◽

Etienne Decencière ◽

Steeve Victorin ◽

...

Keyword(s):

Human Skin ◽

Time Course ◽

Multiphoton Imaging ◽

Course Assessment ◽

Non Invasive

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In vivo assessment of corneal barrier function through non-invasive impedance measurements using a flexible probe

Journal of Physics Conference Series ◽

10.1088/1742-6596/434/1/012072 ◽

2013 ◽

Vol 434 ◽

pp. 012072

Author(s):

A Guimera ◽

X Illa ◽

E Traver ◽

S Marchan ◽

C Herrero ◽

...

Keyword(s):

Barrier Function ◽

Impedance Measurements ◽

Non Invasive ◽

Flexible Probe ◽

In Vivo Assessment

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In vivo multiphoton tomography: a non invasive powerful tool for biochemical investigation of human skin

10.1117/12.727044 ◽

2007 ◽

Author(s):

Ronan Le Harzic ◽

Anne Colonna ◽

Rainer Bückle ◽

Alexander Ehlers ◽

Christophe Hadjur ◽

...

Keyword(s):

Human Skin ◽

Non Invasive ◽

Biochemical Investigation ◽

Multiphoton Tomography

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In vivo non-invasive multiphoton tomography of human skin

10.1117/12.629658 ◽

2005 ◽

Author(s):

Karsten König ◽

Iris Riemann ◽

Alexander Ehlers ◽

Ronan Le Harzic

Keyword(s):

Human Skin ◽

Non Invasive ◽

Multiphoton Tomography

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Intravital multiphoton tomography as an appropriate tool for non-invasive in vivo analysis of human skin affected with atopic dermatitis

10.1117/12.874218 ◽

2011 ◽

Cited By ~ 3

Author(s):

Volker Huck ◽

Christian Gorzelanny ◽

Kai Thomas ◽

Christian Mess ◽

Valentina Dimitrova ◽

...

Keyword(s):

Atopic Dermatitis ◽

Human Skin ◽

Non Invasive ◽

In Vivo Analysis ◽

Multiphoton Tomography

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Computational models for the determination of depth-dependent mechanical properties of skin with a soft, flexible measurement device

Proceedings of The Royal Society A Mathematical Physical and Engineering Sciences ◽

10.1098/rspa.2016.0225 ◽

2016 ◽

Vol 472 (2194) ◽

pp. 20160225 ◽

Cited By ~ 6

Author(s):

Jianghong Yuan ◽

Canan Dagdeviren ◽

Yan Shi ◽

Yinji Ma ◽

Xue Feng ◽

...

Keyword(s):

Human Skin ◽

Output Voltage ◽

Computational Models ◽

Geometrical Parameters ◽

Non Invasive ◽

Conformal Modulus ◽

Flexible Measurement

Conformal modulus sensors (CMS) incorporate PZT nanoribbons as mechanical actuators and sensors to achieve reversible conformal contact with the human skin for non-invasive, in vivo measurements of skin modulus. An analytic model presented in this paper yields expressions that connect the sensor output voltage to the Young moduli of the epidermis and dermis, the thickness of the epidermis, as well as the material and geometrical parameters of the CMS device itself and its encapsulation layer. Results from the model agree well with in vitro experiments on bilayer structures of poly(dimethylsiloxane). These results provide a means to determine the skin moduli (epidermis and dermis) and the thickness of the epidermis from in vivo measurements of human skin.

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