scholarly journals Specificity and immunochemical properties of antibodies to bacterial DNA in sera of normal human subjects and patients with systemic lupus erythematosus (SLE)

1997 ◽  
Vol 109 (1) ◽  
pp. 27-31 ◽  
Author(s):  
Z.-Q. WU ◽  
D. DRAYTON ◽  
D. S. PISETSKY
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Human Subjects ◽  
Systemic Lupus ◽  
Bacterial Dna ◽  
Normal Human

scholarly journals Differences in Susceptibility of Polymorphonuclear Leukocytes from Several Species to Alteration by Systemic Lupus Erythematosus Serum: Application to a More Sensitive L. E. Phenomenon Test

Blood ◽  
1954 ◽  
Vol 9 (12) ◽  
pp. 1165-1171 ◽  
Author(s):  
ANA E. CARRERA ◽  
MAY VIRGINIA REID ◽  
N. B. KURNICK
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Blood Cells ◽  
Polymorphonuclear Leukocytes ◽  
Animal Species ◽  
White Blood Cells ◽  
Systemic Lupus ◽  
Highly Sensitive ◽  
Wide Range ◽  
Normal Human

Abstract Recent investigations have demonstrated that the lupus erythematosus cell phenomenon is influenced, among other things, by intracellular factors. The hypothesis was formulated that leucocytes from different animal species would react with different degrees of intensity to the same L. E. serum. Leucocytes from twelve animal species were tested by counting the number of L. E. cells, "globs" (free homogeneous basophilic masses), droplets and rosettes per 1000 white blood cells and per 1000 P.M.N. after 2 hours’ incubation in the L. E. serum. Controls consisted of similar preparations using normal human serum and homologous plasma. There was a wide range of susceptibility among the various species tested. The chicken and the horse were the most susceptible species, while man fell low in the scale of susceptibility. Classical L. E. cells were produced from leucocytes of most species tested. It is felt that a highly sensitive L. E. test can be performed, using chicken, horse, guinea pig, or dog, instead of human leucocytes.

Organized Intraglomerular Deposits in NZB Mouse Disease

1971 ◽  
Vol 29 ◽  
pp. 544-545
Author(s):  
Francis R. Comerford ◽  
Alan S. Cohen
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Antinuclear Antibodies ◽  
Human Systemic Lupus Erythematosus ◽  
Systemic Lupus ◽  
Glomerular Lesion ◽  
Ultrastructural Studies ◽  
Dense Deposits ◽  
Experimental Nephritis ◽  
Glomerular Lesions

Mice of the inbred NZB strain develop a spontaneous disease characterized by autoimmune hemolytic anemia, positive lupus erythematosus cell tests and antinuclear antibodies and nephritis. This disease is analogous to human systemic lupus erythematosus. In ultrastructural studies of the glomerular lesion in NZB mice, intraglomerular dense deposits in mesangial, subepithelial and subendothelial locations were described. In common with the findings in many examples of human and experimental nephritis, including many cases of human lupus nephritis, these deposits were amorphous or slightly granular in appearance with no definable substructure.We have recently observed structured deposits in the glomeruli of NZB mice. They were uncommon and were found in older animals with severe glomerular lesions by morphologic criteria. They were seen most commonly as extracellular elements in subendothelial and mesangial regions. The deposits ranged up to 3 microns in greatest dimension and were often adjacent to deposits of lipid-like round particles of 30 to 250 millimicrons in diameter and with amorphous dense deposits.

“Subcortical” cognitive impairment in patients with systemic lupus erythematosus

2000 ◽  
Vol 6 (7) ◽  
pp. 821-825 ◽  
Author(s):  
ELIZABETH LERITZ ◽  
JASON BRANDT ◽  
MELISSA MINOR ◽  
FRANCES REIS-JENSEN ◽  
MICHELLE PETRI
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cognitive Impairment ◽  
Lupus Erythematosus ◽  
Systemic Lupus
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