Multicentric clear cell adenocarcinoma in the urinary bladder and the urethral diverticulum: evidence of origin of clear cell adenocarcinoma of the female lower urinary tract from Müllerian duct remnants

To investigate the association among lower urinary tract infection (UTI), the type and timing of antibiotic usage, and the subsequent risk of developing cancers, especially genitourinary cancers (GUC), in Taiwan. This retrospective population-based cohort study was conducted using 2009–2013 data from the Longitudinal Health Insurance Database. This study enrolled patients who were diagnosed with a UTI between 2010 and 2012. A 1:2 propensity score-matched control population without UTI served as the control group. Multivariate analysis with a multiple Cox regression model was applied to analyze the data. A total of 38,084 patients with UTI were included in the study group, and 76,168 participants without UTI were included in the control group. The result showed a higher hazard ratio of any cancer in both sexes with UTI (for males, adjusted hazard ratio (aHR) = 1.32; 95% confidence interval (CI) = 1.12–1.54; for females, aHR = 1.21; 95% CI = 1.08–1.35). Patients with UTI had a higher probability of developing new GUC than those without UTI. Moreover, the genital organs, kidney, and urinary bladder of men were significantly more affected than those of women with prior UTI. Furthermore, antibiotic treatment for more than 7 days associated the incidence of bladder cancer in men (7–13 days, aHR = 1.23, 95% CI = 0.50–3.02; >14 days, aHR = 2.73, CI = 1.32–5.64). In conclusion, UTI is significantly related to GUC and may serve as an early sign of GUC, especially in the male genital organs, prostate, kidney, and urinary bladder. During UTI treatment, physicians should cautiously prescribe antibiotics to patients.

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Abdominoperineal excision of male lower urinary tract for synchronous adenocarcinoma of urethra and urinary bladder

Urology ◽

10.1016/j.urology.2004.09.057 ◽

2005 ◽

Vol 65 (3) ◽

pp. 591 ◽

Cited By ~ 1

Author(s):

Nazim Ali Ahmad ◽

Amanullah Memon ◽

Akbar Hussainy

Keyword(s):

Urinary Tract ◽

Urinary Bladder ◽

Lower Urinary Tract ◽

Abdominoperineal Excision ◽

Lower Urinary

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The relationship between detrusor state and tone of the large intestine and their sphincter apparatus in women with hyperactive urinary bladder

HEALTH OF WOMAN ◽

10.15574/hw.2017.124.32 ◽

2017 ◽

pp. 32-34

Author(s):

S.A. Vozianov ◽

◽

M.P. Zakharash ◽

Yu.M. Zakharash ◽

N.A. Sevast'yanova ◽

...

Keyword(s):

Urinary Tract ◽

Urinary Bladder ◽

Large Intestine ◽

Lower Urinary Tract ◽

High Efficiency ◽

Clinical Manifestations ◽

Distal Colon ◽

Neurogenic Disorders ◽

Neurogenic Dysfunction ◽

Lower Urinary

The objective: increase the effectiveness of diagnosis and treatment of women with a hyperactive bladder, combined neurogenic pathology of the lower urinary tract and distal colon. Patients and methods. The study included 73 women. In assessing the symptoms of clinical manifestations and EMG and UFS data, two groups of patients were identified: the first group – women with increased tone of the neuro-muscular structures of the hyperkinetic type; the second group - women with an increased tone of the neuromuscular structures of the hypokinetic type. In the first group, 37 women were examined, whose mean age was 44.5±2.3 years, and the duration of the disease was 16.7±1.6 months. The second group included 36 women, whose average age was 43.4±2.1 years, and the average duration of the disease was 19.7±1.5 months. Results. The performed treatment showed clinically high efficiency of electrostimulation application depending on the state of the tone of the neuromuscular structures of the lower urinary tract and the distal part of the large intestine, which is confirmed by the data of UFS and EMG. Conclusion. The obtained data allowed to develop and optimize methods of treatment of women with hyperactive urinary bladder with a combined neurogenic pathology of the lower urinary tract and distal division of the large intestine. Key words: neurogenic disorders in urination, intestine neurogenic dysfunction, detrusor, uroflowmetry, electromyography.

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Lower Urinary Tract Neoplasia

Veterinary Sciences ◽

10.3390/vetsci5040096 ◽

2018 ◽

Vol 5 (4) ◽

pp. 96 ◽

Cited By ~ 4

Author(s):

Maureen Griffin ◽

William Culp ◽

Robert Rebhun

Keyword(s):

Urinary Tract ◽

Urinary Bladder ◽

Lower Urinary Tract ◽

Treatment Options ◽

Transitional Cell ◽

Companion Animals ◽

Disease Process ◽

Life Threatening ◽

Comparative Model ◽

Lower Urinary

Lower urinary tract neoplasia in companion animals is a debilitating and often life-threatening disease. Tumors of the bladder, urethra, and prostate often occur independently, although extension of these tumors into adjacent regions of the lower urinary tract is documented frequently. The most common lower urinary tract tumor in dogs and cats is transitional cell carcinoma (TCC). In both dogs and cats, TCC affecting the urinary bladder is generally considered to be highly aggressive with both local and metastatic disease potential, and this disease poses unique treatment challenges. Whereas much literature exists regarding the TCC disease process, treatment options, and prognosis in dogs, relatively few studies on feline TCC have been published due to the lower incidence of TCC in this species. Prostate tumors, most commonly adenocarcinomas, occur less commonly in dogs and cats but serve an important role as a comparative model for prostate neoplasia in humans. This article serves as a review of the current information regarding canine and feline lower urinary tract neoplasia as well as the relevance of these diseases with respect to their human counterparts.

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Congenital Anterior Urethral Diverticulum: A Rare Cause Of Lower Urinary Tract Obstruction In Childhood

The Journal of Urology ◽

10.1016/s0022-5347(17)47423-4 ◽

1985 ◽

Vol 134 (4) ◽

pp. 751-752 ◽

Cited By ~ 3

Author(s):

A.R. Baker ◽

J.P. Neoptolemos ◽

K.F. Wood

Keyword(s):

Urinary Tract ◽

Lower Urinary Tract ◽

Urinary Tract Obstruction ◽

Urethral Diverticulum ◽

Lower Urinary Tract Obstruction ◽

Anterior Urethral Diverticulum ◽

Lower Urinary

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Giant anterior urethra stones combined with a diverticulum: a case report

Annals of The Royal College of Surgeons of England ◽

10.1308/rcsann.2019.0062 ◽

2019 ◽

Vol 101 (6) ◽

pp. e139-e141

Author(s):

S Chen ◽

X Su ◽

M Jiang ◽

H Mi

Keyword(s):

Case Report ◽

Clinical Practice ◽

Urinary Tract ◽

Connective Tissue ◽

Lower Urinary Tract ◽

Urethral Diverticulum ◽

Urinary Frequency ◽

Anterior Urethra ◽

Urinary Tract Symptoms ◽

Lower Urinary

Urethral diverticulum is a condition where the urethra or the periurethral glands push into the connective tissue layers that surround it. Patients of urethral diverticulum present with nonspecific symptoms such as incontinence, urinary frequency and urgency, and pain during sexual intercourse and urination. The incidence of this condition is low. We report a case of giant anterior urethra stones combined with a diverticulum with no lower urinary tract symptoms. We believe that this case is extremely rare, and the process of diagnosis and treatment is of great significance in clinical practice.

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