Abdominoperineal excision of male lower urinary tract for synchronous adenocarcinoma of urethra and urinary bladder

To investigate the association among lower urinary tract infection (UTI), the type and timing of antibiotic usage, and the subsequent risk of developing cancers, especially genitourinary cancers (GUC), in Taiwan. This retrospective population-based cohort study was conducted using 2009–2013 data from the Longitudinal Health Insurance Database. This study enrolled patients who were diagnosed with a UTI between 2010 and 2012. A 1:2 propensity score-matched control population without UTI served as the control group. Multivariate analysis with a multiple Cox regression model was applied to analyze the data. A total of 38,084 patients with UTI were included in the study group, and 76,168 participants without UTI were included in the control group. The result showed a higher hazard ratio of any cancer in both sexes with UTI (for males, adjusted hazard ratio (aHR) = 1.32; 95% confidence interval (CI) = 1.12–1.54; for females, aHR = 1.21; 95% CI = 1.08–1.35). Patients with UTI had a higher probability of developing new GUC than those without UTI. Moreover, the genital organs, kidney, and urinary bladder of men were significantly more affected than those of women with prior UTI. Furthermore, antibiotic treatment for more than 7 days associated the incidence of bladder cancer in men (7–13 days, aHR = 1.23, 95% CI = 0.50–3.02; >14 days, aHR = 2.73, CI = 1.32–5.64). In conclusion, UTI is significantly related to GUC and may serve as an early sign of GUC, especially in the male genital organs, prostate, kidney, and urinary bladder. During UTI treatment, physicians should cautiously prescribe antibiotics to patients.

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The relationship between detrusor state and tone of the large intestine and their sphincter apparatus in women with hyperactive urinary bladder

HEALTH OF WOMAN ◽

10.15574/hw.2017.124.32 ◽

2017 ◽

pp. 32-34

Author(s):

S.A. Vozianov ◽

◽

M.P. Zakharash ◽

Yu.M. Zakharash ◽

N.A. Sevast'yanova ◽

...

Keyword(s):

Urinary Tract ◽

Urinary Bladder ◽

Large Intestine ◽

Lower Urinary Tract ◽

High Efficiency ◽

Clinical Manifestations ◽

Distal Colon ◽

Neurogenic Disorders ◽

Neurogenic Dysfunction ◽

Lower Urinary

The objective: increase the effectiveness of diagnosis and treatment of women with a hyperactive bladder, combined neurogenic pathology of the lower urinary tract and distal colon. Patients and methods. The study included 73 women. In assessing the symptoms of clinical manifestations and EMG and UFS data, two groups of patients were identified: the first group – women with increased tone of the neuro-muscular structures of the hyperkinetic type; the second group - women with an increased tone of the neuromuscular structures of the hypokinetic type. In the first group, 37 women were examined, whose mean age was 44.5±2.3 years, and the duration of the disease was 16.7±1.6 months. The second group included 36 women, whose average age was 43.4±2.1 years, and the average duration of the disease was 19.7±1.5 months. Results. The performed treatment showed clinically high efficiency of electrostimulation application depending on the state of the tone of the neuromuscular structures of the lower urinary tract and the distal part of the large intestine, which is confirmed by the data of UFS and EMG. Conclusion. The obtained data allowed to develop and optimize methods of treatment of women with hyperactive urinary bladder with a combined neurogenic pathology of the lower urinary tract and distal division of the large intestine. Key words: neurogenic disorders in urination, intestine neurogenic dysfunction, detrusor, uroflowmetry, electromyography.

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Lower Urinary Tract Neoplasia

Veterinary Sciences ◽

10.3390/vetsci5040096 ◽

2018 ◽

Vol 5 (4) ◽

pp. 96 ◽

Cited By ~ 4

Author(s):

Maureen Griffin ◽

William Culp ◽

Robert Rebhun

Keyword(s):

Urinary Tract ◽

Urinary Bladder ◽

Lower Urinary Tract ◽

Treatment Options ◽

Transitional Cell ◽

Companion Animals ◽

Disease Process ◽

Life Threatening ◽

Comparative Model ◽

Lower Urinary

Lower urinary tract neoplasia in companion animals is a debilitating and often life-threatening disease. Tumors of the bladder, urethra, and prostate often occur independently, although extension of these tumors into adjacent regions of the lower urinary tract is documented frequently. The most common lower urinary tract tumor in dogs and cats is transitional cell carcinoma (TCC). In both dogs and cats, TCC affecting the urinary bladder is generally considered to be highly aggressive with both local and metastatic disease potential, and this disease poses unique treatment challenges. Whereas much literature exists regarding the TCC disease process, treatment options, and prognosis in dogs, relatively few studies on feline TCC have been published due to the lower incidence of TCC in this species. Prostate tumors, most commonly adenocarcinomas, occur less commonly in dogs and cats but serve an important role as a comparative model for prostate neoplasia in humans. This article serves as a review of the current information regarding canine and feline lower urinary tract neoplasia as well as the relevance of these diseases with respect to their human counterparts.

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Endoscopic examination of the urethra and the urinary bladder in dogs – indications, contraindications and performance technique

Polish Journal of Veterinary Sciences ◽

10.2478/pjvs-2013-0114 ◽

2013 ◽

Vol 16 (4) ◽

pp. 797-801 ◽

Cited By ~ 2

Author(s):

M. Grzegory ◽

K. Kubiak ◽

M. Jankowski ◽

J. Spużak ◽

K. Glińska-Suchocka ◽

...

Keyword(s):

Urinary Tract ◽

Urinary Bladder ◽

Lower Urinary Tract ◽

Endoscopic Examination ◽

Performance Technique ◽

Performance Techniques ◽

And Performance ◽

Lower Urinary

Abstract This paper discusses indications, contraindications, and likely complications following the endoscopic examination of the urethra and the urinary bladder in dogs. In addition, the procedure performance techniques and evaluation of the particular sections of the lower urinary tract are presented as well as the equipment used for the urethrocystoscopy.

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Assessment of urinary 15‐F 2 ‐isoprostanes in dogs with urothelial carcinoma of the urinary bladder and other lower urinary tract diseases

Journal of Veterinary Internal Medicine ◽

10.1111/jvim.15877 ◽

2020 ◽

Vol 34 (6) ◽

pp. 2454-2459

Author(s):

Andrew D. Woolcock ◽

Adrienne Cheney ◽

Pierre Deshuillers ◽

Deborah Knapp ◽

George E. Moore

Keyword(s):

Urinary Tract ◽

Urinary Bladder ◽

Urothelial Carcinoma ◽

Lower Urinary Tract ◽

Lower Urinary

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Expression and function of transforming growth factor-β isoforms and cognate receptors in the rat urinary bladder following cyclophosphamide-induced cystitis

AJP Renal Physiology ◽

10.1152/ajprenal.00042.2013 ◽

2013 ◽

Vol 305 (9) ◽

pp. F1265-F1276 ◽

Cited By ~ 20

Author(s):

Eric J. Gonzalez ◽

Beatrice M. Girard ◽

Margaret A. Vizzard

Keyword(s):

Urinary Tract ◽

Growth Factor ◽

Urinary Bladder ◽

Lower Urinary Tract ◽

Transforming Growth Factor ◽

Bladder Capacity ◽

Transforming Growth Factor Β ◽

Rat Urinary Bladder ◽

Urinary Bladder Dysfunction ◽

Lower Urinary

Numerous proinflammatory cytokines have been implicated in the reorganization of lower urinary tract function following cyclophosphamide (CYP)-induced cystitis. The present study investigated the functional profile of three pleiotropic transforming growth factor-β (TGF-β) isoforms and receptor (TβR) variants in the normal and inflamed (CYP-induced cystitis) rat urinary bladder. Our findings indicate that TGF-β (1, 2, and 3) and TβR (1, 2, and 3) transcript and protein expression were regulated to varying degrees in the urothelium or detrusor smooth muscle following intermediate (48 h; 150 mg/kg ip) or chronic (75 mg/kg ip; once every 3 days for 10 days), but not acute (4 h; 150 mg/kg ip), CYP-induced cystitis. Conscious, open-outlet cystometry was performed to determine whether aberrant TGF-β signaling contributes to urinary bladder dysfunction following intermediate (48 h) CYP-induced cystitis. TβR-1 inhibition with SB505124 (5 μM) significantly (p ≤ 0.001) decreased voiding frequency and increased bladder capacity (2.5-fold), void volume (2.6-fold), and intercontraction intervals (2.5-fold) in CYP-treated (48 h) rats. Taken together, these results provide evidence for 1) the involvement of TGF-β in lower urinary tract neuroplasticity following urinary bladder inflammation, 2) a functional role of TGF-β signaling in the afferent limb of the micturition reflex, and 3) urinary bladder TβR-1 as a viable target to reduce voiding frequency with cystitis.

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Erratum to “Does Urinary Bladder Shape Affect Urinary Flow Rate in Men with Lower Urinary Tract Symptoms?”

The Scientific World JOURNAL ◽

10.1155/2014/462623 ◽

2014 ◽

Vol 2014 ◽

pp. 1-1

Author(s):

Yusuf Ziya Ateşçi ◽

Özgü Aydoğdu ◽

Ayhan Karaköse ◽

Mahmut Pekedis ◽

Ömer Karal ◽

...

Keyword(s):

Urinary Tract ◽

Urinary Bladder ◽

Lower Urinary Tract Symptoms ◽

Flow Rate ◽

Lower Urinary Tract ◽

Urinary Flow Rate ◽

Urinary Flow ◽

Urinary Tract Symptoms ◽

Lower Urinary

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A case of congenital ureteral atresia causing rare upper and lower urinary tract manifestations in a puppy: a case report

BMC Veterinary Research ◽

10.1186/s12917-021-02780-6 ◽

2021 ◽

Vol 17 (1) ◽

Author(s):

Megan Zalek ◽

Rohan Shah ◽

Timothy Bolton

Keyword(s):

Renal Function ◽

Urinary Tract ◽

Urinary Bladder ◽

Lower Urinary Tract ◽

Distal Ureter ◽

Case Presentation ◽

Tract Disease ◽

Regional Compression ◽

Lower Urinary

Abstract Background Ureteral atresia is the congenital absence of a ureteral opening, resulting in a blind-ended ureter that fails to terminate at the urinary bladder. Consequently, severe hydroureter and hydronephrosis occur ipsilateral to the atresic ureter. However, hydronephrosis contralateral to severe hydroureter, although reported in humans, is not documented in the dog. Additionally, ureteral atresia has not been reported as a cause for lower urinary tract signs directly related to extramural urinary bladder compression. This report aims to describe these unique manifestations of this congenital urinary tract disease, as well as follow-up findings after successful treatment. Case presentation A 4-month-old male Husky puppy was evaluated for pollakiuria, stranguria, and urine dribbling of 1-month duration. During the physical examination, a mass was palpated in the mid-abdomen. Diagnostic imaging and cystoscopy findings were diagnostic for right-sided ureteral atresia with secondary hydroureter and hydronephrosis. The severe right hydroureter caused lower urinary tract signs and contralateral hydronephrosis secondary to regional compression of the left distal ureter and urinary bladder. A right-sided ureteronephrectomy was performed, resolving the stranguria and pollakiuria. Significant reduction in the contralateral (left) hydronephrosis also occurred. Clinical Relevance Ureteral atresia should be considered as a differential diagnosis for lower urinary tract signs and/or bilateral hydronephrosis in a young dog. Reporting this case expands our knowledge of congenital lower urinary tract disease and the etiology of their manifestations in dogs. Surgical resolution of the congenital ureteral abnormality can result in preservation of renal function in the contralaterally obstructed kidney.

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