scholarly journals Interleukin-3, but not granulocyte-macrophage colony-stimulating factor and interleukin-5, inhibits apoptosis of human basophils through phosphatidylinositol 3-kinase: requirement of NF-κB-dependent and -independent pathways

Immunology ◽  
2002 ◽  
Vol 107 (3) ◽  
pp. 306-315 ◽  
Author(s):  
Xueyan Zheng ◽  
Aly Karsan ◽  
Vincent Duronio ◽  
Fanny Chu ◽  
David C. Walker ◽  
...  
Keyword(s):  
Colony Stimulating Factor ◽  
Phosphatidylinositol 3 Kinase ◽  
Interleukin 5 ◽  
Interleukin 3 ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Stimulating Factor ◽  
Human Basophils ◽  
Phosphatidylinositol 3

scholarly journals A mutation of the common receptor subunit for interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor, and IL-5 that leads to ligand independence and tumorigenicity

Blood ◽  
1994 ◽  
Vol 83 (10) ◽  
pp. 2802-2808 ◽  
Author(s):  
R D'Andrea ◽  
J Rayner ◽  
P Moretti ◽  
A Lopez ◽  
GJ Goodall ◽  
...  
Keyword(s):  
Large Family ◽  
Mutant Form ◽  
Sequence Motifs ◽  
Colony Stimulating Factor ◽  
Interleukin 5 ◽  
Interleukin 3 ◽  
Conserved Sequence ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Stimulating Factor

Abstract The cytokines interleukin-3, interleukin-5, and granulocyte-macrophage colony-stimulating factor bind with high affinity to a receptor complex that contains a ligand-specific alpha-chain and a common beta-chain, h beta c. We report here the isolation of a mutant form of h beta c, from growth factor-independent cells, that arose spontaneously after infection of a murine factor-dependent hematopoietic cell line (FDC-P1) with a retroviral h beta c expression construct. Analysis of this h beta c mutation shows that a small (37 amino acid) duplication of extracellular sequence that includes two conserved sequence motifs is sufficient to confer ligand-independent growth on these cells and lead to tumourigenicity. Because this is a conserved region in the cytokine receptor superfamily, our results suggest that the large family of cytokine receptors has the capacity to become oncogenically active.

Interleukin-3, granulocyte-macrophage colony-stimulating factor, and interleukin-5 transduce signals through two forms of STAT5

1995 ◽  
Vol 57 (5) ◽  
pp. 799-803 ◽  
Author(s):  
Alice L.-F. Mui ◽  
Hiroshi Wakao ◽  
Nobuyuki Harada ◽  
Anne-Marie O'Farrell ◽  
Atsushi Miyajima
Keyword(s):  
Colony Stimulating Factor ◽  
Interleukin 5 ◽  
Interleukin 3 ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Stimulating Factor
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