Comparison between a new PVC platelet storage container (UPX80) and a polyolefin container

2000 ◽  
Vol 10 (2) ◽  
pp. 131-139 ◽  
Author(s):  
Kostelijk ◽  
Gouwerok ◽  
Veldman ◽  
de Korte
Keyword(s):  
Storage Container ◽  
Platelet Storage

scholarly journals Acquired platelet storage container leaks and contamination with environmental bacteria: A preventable cause of bacterial sepsis

Transfusion ◽  
2021 ◽  
Author(s):  
Richard R. Gammon ◽  
Rita A. Reik ◽  
Marc Stern ◽  
Ralph R. Vassallo ◽  
Dan A. Waxman ◽  
...  
Keyword(s):  
Bacterial Sepsis ◽  
Storage Container ◽  
Platelet Storage ◽  
Environmental Bacteria

Loss of Thrombin-Induced Ca2+ Mobilization in a Subpopulation of Platelets during Storage

1991 ◽  
Vol 66 (03) ◽  
pp. 350-354 ◽  
Author(s):  
Rob Fijnheer ◽  
Christa H E Homburg ◽  
Berend Hooibrink ◽  
Martine N Boomgaard ◽  
Dirk de Korte ◽  
...  
Keyword(s):  
Human Platelets ◽  
Flow Cytometer ◽  
Maximal Concentration ◽  
Gradual Decline ◽  
Platelet Storage ◽  
Functional Defect ◽  
Total Fluorescence ◽  
Induced Changes

SummaryThrombin-induced changes in cytosolic free Ca2+ ([Ca2+]i) were studied in human platelets that had been stored for up to 6 days. Changes in [Ca2+]i were measured with Indo-1-loaded platelets and quantitated with two different methods: (i) measurement of the changes in total fluorescence; (ii) measurement of the [Ca2+]i changes in individual platelets in a flow cytometer, allowing the detection of non-responding platelets. The maximal concentration of [Ca2+]i after stimulation with 0.5 U of thrombin/ml decreased from 544 ± 58 nM (mean ± SEM, n = 6) on day 0, to 276 ± 9 nM on day 3 and to 203 ± 23 nM on day 6. The percentage of platelets responding to 0.5 U of thrombin/ml declined from 90 ± 2% on day 0 to 72 ± 4% on day 3, and to 47 ± 8% on day 6. Nevertheless, also the responding platelets showed a decreased rise in [Ca2+]i.The study shows that during platelet storage a decrease in the rise in [Ca2+]i upon thrombin stimulation occurs. This decrease is partly due to the formation of a subpopulation of platelets that is completely unresponsive and partly due to a decreased responsiveness in the remainder of the platelets; it is not due to a gradual decline in [Ca2+]i rise in all platelets. This phenomenon provides new insight in the functional defect of stored platelets.

Correlation Between Noradrenaline Fluxes, Metabolism and Compartmentalisation in Human Platelets

1982 ◽  
Vol 48 (01) ◽  
pp. 062-066 ◽  
Author(s):  
Chantal Legrand ◽  
Véronique Dubernard ◽  
Philippe Meyer
Keyword(s):  
Noradrenaline Release ◽  
Human Platelets ◽  
Release Of Noradrenaline ◽  
Storage Pool ◽  
Platelet Storage ◽  
Efflux Of Noradrenaline ◽  
Preferential Localization

Summary(3H) noradrenaline was taken up by human platelets and partially converted into sulfoconjugated noradrenaline. This uptake was inhibited by drugs which have been previously shown to impair the uptake of 5-HT (ouabain, chlorimipramine) or the storage of 5-HT (tyramine, reserpine) by platelets. In addition, tyramine and reserpine stimulated the formation of sulfoconjugated noradrenaline. The efflux of noradrenaline from platelets was measured in parallel and was found to be directly related to the proportion of non metabolized to metabolized noradrenaline in the cells. Unlike tyramine, which induced a similar release of noradrenaline and 5-HT, reserpine was less effective at inducing noradrenaline release than 5-HT release. This study indicates a preferential localization of noradrenaline in the granular pool of human platelets with the existence of an extragranular sulfoconjugated pool which is increased when the granular storage of noradrenaline is impaired. Studies of noradrenaline fluxes and metabolism may be useful in the understanding of both acquired and inherited platelet storage pool defects.

Detection of an Acquired Platelet Storage Pool Disease in Three Patients with a Myeloproliferative Disorder

1979 ◽  
Vol 42 (02) ◽  
pp. 794-796 ◽  
Author(s):  
Francine Rendu ◽  
Marilyne Lebret ◽  
Alan Nurden ◽  
Jacques P Caen
Keyword(s):  
Myeloproliferative Disorder ◽  
Storage Pool ◽  
Platelet Storage ◽  
Storage Pool Disease

scholarly journals Platelet storage and functional integrity

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Gianmatteo Vit ◽  
Harald Klüter ◽  
Patrick Wuchter
Keyword(s):  
Platelet Transfusion ◽  
Structural Characteristics ◽  
Storage Conditions ◽  
Transfusion Practice ◽  
Common Interest ◽  
Laboratory Staff ◽  
German Medical Association ◽  
Platelet Storage ◽  
Technological Advances ◽  
Assessment Procedures

AbstractPlatelet transfusion is a topic of common interest for many specialists involved in patient care, from laboratory staff to clinical physicians. Various aspects make this type of transfusion different from those of other blood components. In this review, the challenges in platelet transfusion practice that are relevant for laboratory colleagues will be discussed, highlighting how the biochemical and structural characteristics of these blood elements directly affect their function and consequently the clinical outcome. More than 1,300 platelet concentrates are transfused in Germany every day, and several types are offered by their respective manufacturers. We describe the technological advances in platelet concentrate production, with a focus on how the storage conditions of platelets can be improved. Laboratory quality assessment procedures for a safe transfusion are discussed in detail. For this purpose, we will refer to the Hemotherapy Directives (Richtlinie Hämotherapie) of the German Medical Association.

scholarly journals Using CO2 as a Cooling Fluid for Power Plants: A Novel Approach for CO2 Storage and Utilization

2021 ◽  
Vol 11 (11) ◽  
pp. 4974
Author(s):  
Tran X. Phuoc ◽  
Mehrdad Massoudi
Keyword(s):  
Power Plant ◽  
Power Plants ◽  
Saturated Vapor ◽  
Co2 Storage ◽  
Storage Container ◽  
Cooling Fluid ◽  
Capital Costs ◽  
Dry Air ◽  
Novel Approach ◽  
Power Plant Cooling

To our knowledge, the potential use of CO2 as a heat-transmitting fluid for cooling applications in power plants has not been explored very extensively. In this paper, we conduct a theoretical analysis to explore the use of CO2 as the heat transmission fluid. We evaluate and compare the thermophysical properties of both dry air and CO2 and perform a simple analysis on a steam-condensing device where steam flows through one of the flow paths and the cooling fluid (CO2 or air) is expanded from a high-pressure container and flows through the other. Sample calculations are carried out for a saturated-vapor steam at 0.008 MPa and 41.5 °C with the mass flow rate of 0.01 kg/s. The pressure of the storage container ranges from 1 to 5 MPa, and its temperature is kept at 35 °C. The pressure of the cooling fluid (CO2 or dry air) is set at 0.1 MPa. With air as the heat-removing fluid, the steam exits the condensing device as a vapor-liquid steam of 53% to 10% vapor for the container pressure of 1 to 5 MPa. With CO2 as the heat-removing fluid, the steam exits the device still containing 44% and 7% vapor for the container pressure of 1 MPa and 2 MPa, respectively. For the container pressure of 3 MPa and higher, the steam exits the device as a single-phase saturated liquid. Thus, due to its excellent Joule–Thomson cooling effect and heat capacity, CO2 is a better fluid for power plant cooling applications. The condensing surface area is also estimated, and the results show that when CO2 is used, the condensing surface is 50% to 60% less than that when dry air is used. This leads to significant reductions in the condenser size and the capital costs. A rough estimate of the amount of CO2 that can be stored and utilized is also carried out for a steam power plant which operates with steam with a temperature of 540 °C (813 K) and a pressure of 10 MPa at the turbine inlet and saturated-vapor steam at 0.008 MPa at the turbine outlet. The results indicate that if CO2 is used as a cooling fluid, CO2 emitted from a 1000 MW power plant during a period of 250 days could be stored and utilized.

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