scholarly journals Effect of single mutations on the structural dynamics of a DNA repair enzyme, the Escherichia coli formamidopyrimidine-DNA glycosylase . A fluorescence study using tryptophan residues as reporter groups

1998 ◽  
Vol 253 (2) ◽  
pp. 413-420 ◽  
Author(s):  
Serguei V. Kuznetsov ◽  
Olga M. Sidorkina ◽  
Juan Jurado ◽  
Marc Bazin ◽  
Patrick Tauc ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Dna Repair ◽  
Structural Dynamics ◽  
Dna Glycosylase ◽  
Fluorescence Study ◽  
Repair Enzyme ◽  
Tryptophan Residues

scholarly journals Three-Dimensional Structure of a DNA Repair Enzyme, 3-Methyladenine DNA Glycosylase II, from Escherichia coli

Cell ◽  
1996 ◽  
Vol 86 (2) ◽  
pp. 311-319 ◽  
Author(s):  
Yuriko Yamagata ◽  
Masato Kato ◽  
Kyoko Odawara ◽  
Yoshiteru Tokuno ◽  
Yoko Nakashima ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Dna Repair ◽  
Three Dimensional ◽  
Dna Glycosylase ◽  
Dimensional Structure ◽  
Repair Enzyme ◽  
Three Dimensional Structure

A mammalian cell line deficient in activity of the DNA repair enzyme 5-hydroxymethyluracil-DNA glycosylase is resistant to the toxic effects of the thymidine analog 5-hydroxymethyl-2'-deoxyuridine

1992 ◽  
Vol 12 (12) ◽  
pp. 5536-5540
Author(s):  
R J Boorstein ◽  
L N Chiu ◽  
G W Teebor
Keyword(s):  
Dna Repair ◽  
Cell Line ◽  
Mammalian Cell ◽  
Dna Glycosylase ◽  
Mammalian Cell Line ◽  
Repair Enzyme ◽  
Thymidine Analog ◽  
Large Numbers ◽  
Mechanism Of Toxicity ◽  
Base Excision

We isolated a mutant mammalian cell line lacking activity for the DNA repair enzyme 5-hydroxymethyluracil-DNA glycosylase (HmUra-DNA glycosylase). The mutant was isolated through its resistance to the thymidine analog 5-hydroxymethyl-2'-deoxyuridine (HmdUrd). The mutant incorporates HmdUrd into DNA to the same extent as the parent line but, lacking the repair enzyme, does not remove it. The phenotype of the mutant demonstrates that the toxicity of HmdUrd does not result from substitution of thymine in DNA by HmUra but rather from the removal via base excision of large numbers of HmUra residues in DNA. This finding elucidates a novel mechanism of toxicity for a xenobiotic nucleoside. Furthermore, the isolation of this line supports our hypothesis that the enzymatic repairability of HmUra derives not from its formation opposite adenine via the oxidation of thymine, but rather from its formation opposite guanine as a product of the oxidation and subsequent deamination of 5-methylcytosine.

Multiple microRNAs may regulate the DNA repair enzyme uracil-DNA glycosylase

DNA Repair ◽  
2013 ◽  
Vol 12 (1) ◽  
pp. 80-86 ◽  
Author(s):  
Siv A. Hegre ◽  
Pål Sætrom ◽  
Per A. Aas ◽  
Henrik S. Pettersen ◽  
Marit Otterlei ◽  
...  
Keyword(s):  
Dna Repair ◽  
Dna Glycosylase ◽  
Repair Enzyme ◽  
Uracil Dna Glycosylase

scholarly journals Division-induced DNA double strand breaks in the chromosome terminus region of Escherichia coli lacking RecBCD DNA repair enzyme

PLoS Genetics ◽  
2017 ◽  
Vol 13 (10) ◽  
pp. e1006895 ◽  
Author(s):  
Anurag Kumar Sinha ◽  
Adeline Durand ◽  
Jean-Michel Desfontaines ◽  
Ielyzaveta Iurchenko ◽  
Hélène Auger ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Dna Repair ◽  
Double Strand Breaks ◽  
Dna Double Strand Breaks ◽  
Repair Enzyme ◽  
Strand Breaks

scholarly journals Molecular cloning of human uracil-DNA glycosylase, a highly conserved DNA repair enzyme.

1989 ◽  
Vol 8 (10) ◽  
pp. 3121-3125 ◽  
Author(s):  
L.C. Olsen ◽  
R. Aasland ◽  
C.U. Wittwer ◽  
H.E. Krokan ◽  
D.E. Helland
Keyword(s):  
Dna Repair ◽  
Molecular Cloning ◽  
Dna Glycosylase ◽  
Repair Enzyme ◽  
Uracil Dna Glycosylase

The effect of p53 on the DNA repair enzyme Thymine-DNA Glycosylase

2008 ◽  
Vol 6 (9) ◽  
pp. 47
Author(s):  
N. Meireles da Costa ◽  
A. Hautefeuille ◽  
M. Pierre Cros ◽  
L.F. Ribeiro Pinto ◽  
P. Hainaut
Keyword(s):  
Dna Repair ◽  
Dna Glycosylase ◽  
Repair Enzyme ◽  
Thymine Dna Glycosylase
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