Fetal cerebral blood flow redistribution in late gestation: identification of compromise in small fetuses with normal umbilical artery Doppler

2000 ◽  
Vol 15 (3) ◽  
pp. 209-212 ◽  
Author(s):  
R. Hershkovitz ◽  
J.C.P. Kingdom ◽  
M. Geary ◽  
C.H. Rodeck
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Umbilical Artery ◽  
Late Gestation ◽  
Umbilical Artery Doppler ◽  
Blood Flow Redistribution

scholarly journals OC04.02: Fetal growth rate and cerebral blood flow redistribution in suspected late fetal growth restriction

2021 ◽  
Vol 58 (S1) ◽  
pp. 10-11
Author(s):  
T. Stampalija ◽  
H. Wolf ◽  
B. Mylrea Foley ◽  
K. Stephens ◽  
C. Lees ◽  
...  
Keyword(s):  
Growth Rate ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Growth Restriction ◽  
Blood Flow Redistribution

Cardiovascular responses to graded degrees of hypoxaemia in the llama fetus

1995 ◽  
Vol 7 (3) ◽  
pp. 549 ◽  
Author(s):  
AJ Llanos ◽  
RA Riquelme ◽  
FA Moraga ◽  
G Cabello ◽  
JT Parer
Keyword(s):  
Blood Flow ◽  
Cardiac Output ◽  
Cerebral Blood Flow ◽  
Cardiovascular Response ◽  
Blood Gases ◽  
Cardiovascular Responses ◽  
Fetal Sheep ◽  
Severe Hypoxaemia ◽  
The Central Nervous System ◽  
Blood Flow Redistribution

The fetal llama exposed to an intense degree of hypoxaemia did not increase cerebral blood flow, but showed a marked peripheral vasoconstriction. The same cardiovascular response is observed in fetal sheep submitted to a extremely severe hypoxaemia, when the initial compensatory vasodilatory mechanisms in brain and heart fail. To investigate whether the fetal llama responses to acute hypoxaemia are adaptive, or whether they are the result of a breakdown of mechanisms of blood flow redistribution that favours the central nervous system, we studied seven fetal llamas (0.6-0.7 of gestation) chronically-catheterized during 1 h of graded and progressive hypoxaemia. Fetal ascending aorta blood gases and fetal cardiac output and its distribution (radiolabelled-microspheres) were measured after 60 min of normoxaemia (B) and at the end of 20 min (H20), 40 min (H40) and 60 min (H60) of hypoxaemia. Data were analysed by ANOVA and Newman-Keuls tests. Each treatment resulted in a lower (P < 0.05) percentage of haemoglobin saturation than hypoxaemia; H40 was lower than H20, and H60 was lower than H20 and H40. No statistical difference was observed among treatments for cardiac output or cerebral blood flow. These results demonstrate that fetal cardiac output and brain blood flow are maintained at all degrees of hypoxaemia, indicating that these cardiovascular responses are an adaptive response in the llama fetus, rather than an index of cardiorespiratory decompensation.

scholarly journals OP13.01: Cerebral blood flow redistribution in fetuses with congenital heart disease

2013 ◽  
Vol 42 (s1) ◽  
pp. 82-82
Author(s):  
F. D'Antonio ◽  
A. Khalil ◽  
A. Bhide ◽  
J. Carvalho ◽  
B. Thilaganathan
Keyword(s):  
Congenital Heart Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Heart Disease ◽  
Congenital Heart ◽  
Blood Flow Redistribution

scholarly journals Fetal Cerebral Blood Flow and Metabolism during Oligemia and Early Postoligemic Reperfusion

1991 ◽  
Vol 11 (3) ◽  
pp. 416-423 ◽  
Author(s):  
Conrad R. Chao ◽  
A. Roger Hohimer ◽  
John M. Bissonnette
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Oxygen Consumption ◽  
Oxygen Delivery ◽  
Reactive Hyperemia ◽  
Fetal Brain ◽  
Early Time ◽  
Late Gestation ◽  
Fetal Sheep ◽  
Early Reperfusion

The early time period following ischemia may be of pathogenetic importance in hypoxic-ischemic brain injury. Global cerebral oligemia was induced in ten late gestation fetal sheep by inflation of a balloon occluder around the brachiocephalic artery. Cerebral blood flow, oxygen, glucose, and lactate net flux, and oxygen delivery were measured by the Fick principle following 1 h of oligemia and at 5, 30, and 60 min of postoligemic reperfusion. During oligemia, cerebral blood flow decreased by 74 ± 10% (mean ± SD) and oxygen consumption decreased by 34 ± 24%. The glucose:oxygen quotient was elevated throughout the oligemic period. In the early (5 min) reperfusion period, blood flow and oxygen delivery were not different from control but oxygen consumption was persistently depressed by 27 ± 32%; fractional extraction of oxygen was 0.38 ± 0.10 during control and 0.24 ± 0.09 during early reperfusion. The venous oxygen tension increased modestly from 15.2 ± 2.4 to 18.0 ± 1.7 mm Hg; the postoligemic venous pO2 was limited by the lack of reactive hyperemia combined with the low arterial pO2 of the intrauterine environment. Postoligemic carbohydrate fluxes could not be differentiated from control, possibly due to blood–brain barrier limitations. These factors may be related to the relative resistance of the fetal brain to hypoxic–ischemic injury.

Network-wise cerebral blood flow redistribution after 20 Hz rTMS on left dorso-lateral prefrontal cortex

2018 ◽  
Vol 101 ◽  
pp. 144-148 ◽  
Author(s):  
Yuan-Qi Shang ◽  
Jun Xie ◽  
Wei Peng ◽  
Jian Zhang ◽  
Da Chang ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Prefrontal Cortex ◽  
Lateral Prefrontal Cortex ◽  
Blood Flow Redistribution

scholarly journals Effects of betamethasone administration to the fetal sheep in late gestation on fetal cerebral blood flow

2000 ◽  
Vol 528 (3) ◽  
pp. 619-632 ◽  
Author(s):  
Matthias Schwab ◽  
Marcus Roedel ◽  
M. Akhtar Anwar ◽  
Thomas Müller ◽  
Harald Schubert ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Late Gestation ◽  
Fetal Sheep

scholarly journals Postnatal Systemic Blood Flow in Neonates with Abnormal Fetal Umbilical Artery Doppler

2014 ◽  
Vol 2014 ◽  
pp. 1-6
Author(s):  
Richelle N. Olsen ◽  
Jennifer Shepherd ◽  
Anup Katheria
Keyword(s):  
Blood Flow ◽  
Umbilical Artery ◽  
Superior Vena ◽  
Vena Cava ◽  
Adverse Outcomes ◽  
Systemic Blood ◽  
Systemic Blood Flow ◽  
Future Studies ◽  
Gestational Age At Delivery ◽  
Umbilical Artery Doppler

Objective. Abnormal umbilical artery Doppler (UAD) studies are associated with poor neonatal outcomes. We sought to determine if postnatal measures of systemic blood flow (SBF), as measured by functional echocardiography (fECHO), could identify which fetuses with abnormal UAD were at the highest risk of adverse outcomes. Study Design. This is a retrospective review of fetuses with abnormal UAD who received fECHO in the first 72 hours of life. Measures of SBF (right ventricular output (RVO) and superior vena cava (SVC) flow) were performed and compared with prenatal variables and postnatal outcomes. Result. 63 subjects had abnormal UAD, 20 of which also had fECHO. Six subjects had abnormal flow. Gestational age at delivery was similar between the two groups. Those with abnormal SBF had fewer days of abnormal UAD prior to delivery and developed RDS (P<0.001). Conclusion. Postnatal measures of SBF were associated with poor postnatal outcomes in fetuses with abnormal UAD. Future studies incorporating antenatal measures of SBF may help obstetricians determine which pregnancies complicated by UAD are likely to have postnatal morbidity.

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