Effect of Chronic Cocaine Treatment on μ- and δ-Opioid Receptor mRNA Levels in Dopaminergically Innervated Brain Regions

2002 ◽  
Vol 66 (2) ◽  
pp. 443-448 ◽  
Author(s):  
Anahit V. Azaryan ◽  
Linda J. Coughlin ◽  
Beáta Búzás ◽  
Barbara J. Clock ◽  
Brian M. Cox
Keyword(s):  
Opioid Receptor ◽  
Brain Regions ◽  
Mrna Levels ◽  
Receptor Mrna ◽  
Chronic Cocaine ◽  
Δ Opioid Receptor

Effect of supraspinal antisense oligodeoxynucleotide treatment on δ-opioid receptor mRNA levels in mice

1997 ◽  
Vol 48 (1) ◽  
pp. 17-22 ◽  
Author(s):  
Cynthia E Lee ◽  
Benjamin Kest ◽  
Shirzad Jenab ◽  
Charles E Inturrisi
Keyword(s):  
Opioid Receptor ◽  
Antisense Oligodeoxynucleotide ◽  
Mrna Levels ◽  
Receptor Mrna ◽  
Δ Opioid Receptor

Cocaine modulates mu-opioid receptor mRNA but not c-fos mRNA levels in primary cortical astrocytes

2002 ◽  
Vol 58 (3) ◽  
pp. 285-288 ◽  
Author(s):  
Eugene D Festa ◽  
Christine Cecala ◽  
Vanya Quinones-Jenab ◽  
Shirzad Jenab
Keyword(s):  
Opioid Receptor ◽  
Mu Opioid Receptor ◽  
Mrna Levels ◽  
Mu Opioid ◽  
Receptor Mrna ◽  
Cortical Astrocytes

Chronic opioid antagonist administration upregulates mu opioid receptor binding without altering mu opioid receptor mRNA levels

1995 ◽  
Vol 33 (2) ◽  
pp. 351-355 ◽  
Author(s):  
Ellen M. Unterwald ◽  
Joshua M. Rubenfeld ◽  
Yasuo Imai ◽  
Jia-Bei Wang ◽  
George R. Uhl ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Receptor Binding ◽  
Mu Opioid Receptor ◽  
Opioid Antagonist ◽  
Mrna Levels ◽  
Mu Opioid ◽  
Receptor Mrna ◽  
Opioid Receptor Binding

Chronic morphine and naltrexone fail to modify μ-opioid receptor mRNA levels in the rat brain

1997 ◽  
Vol 45 (1) ◽  
pp. 149-153 ◽  
Author(s):  
M.Paola Castelli ◽  
Miriam Melis ◽  
Michela Mameli ◽  
Paola Fadda ◽  
Giacomo Diaz ◽  
...  
Keyword(s):  
Rat Brain ◽  
Opioid Receptor ◽  
Mrna Levels ◽  
Chronic Morphine ◽  
Receptor Mrna ◽  
Μ Opioid Receptor

cAMP decreases steady- state levels of δ -opioid receptor mRNA in NG108-15 cells

Neuroreport ◽  
1997 ◽  
Vol 8 (9) ◽  
pp. 2369-2372 ◽  
Author(s):  
Karen H. Gylys ◽  
Nicole Tran ◽  
Karen Magendzo ◽  
Paulette Zaki ◽  
Christopher J. Evans
Keyword(s):  
Steady State ◽  
Opioid Receptor ◽  
Receptor Mrna ◽  
Steady State Levels ◽  
Δ Opioid Receptor

scholarly journals Mu opioid receptor and orexin/hypocretin mRNA levels in the lateral hypothalamus and striatum are enhanced by morphine withdrawal

2006 ◽  
Vol 191 (1) ◽  
pp. 137-145 ◽  
Author(s):  
Yan Zhou ◽  
Jacob Bendor ◽  
Lauren Hofmann ◽  
Matthew Randesi ◽  
Ann Ho ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Lateral Hypothalamus ◽  
Brain Regions ◽  
Mu Opioid Receptor ◽  
Morphine Withdrawal ◽  
Mrna Levels ◽  
Chronic Morphine ◽  
Mu Opioid ◽  
Morphine Administration ◽  
Related Stress

In this study, we investigated the effects of acute morphine administration, chronic intermittent escalating-dose morphine administration and spontaneous withdrawal from chronic morphine on mRNA levels of mu opioid receptor (MOP-r), and the opioid peptides pro-opiomelanocortin (POMC) and preprodynorphin (ppDyn) in several key brain regions of the rat, associated with drug reward and motivated behaviors: lateral hypothalamus (lat.hyp), nucleus accumbens (NAc) core, amygdala, and caudate–putamen (CPu). There was no effect on MOP-r mRNA levels in these brain regions 30 min after either a single injection of morphine (10 mg/kg, i.p.) or chronic intermittent escalating-dose morphine (from 7.5 mg/kg per day on day 1 up to 120 mg/kg per day on day 10). Activation of the stress-responsive hypothalamic–pituitary–adrenal axis by 12 h withdrawal from chronic morphine was confirmed; both POMC mRNA levels in the anterior pituitary and plasma adrenocorticotropic hormone levels were significantly elevated. Under this withdrawal-related stress condition, there was an increase in MOP-r mRNA levels in the lat.hyp, NAc core, and CPu. Recent studies have demonstrated a novel role for the lat.hyp orexin (or hypocretin) activation in both drug-related positive rewarding, and withdrawal effects. Around 50% of lat.hyp orexin neurons express MOP-r. Therefore, we also examined the levels of lat.hyp orexin mRNA, and found them increased in morphine withdrawal, whereas there was no change in levels of the lat.hyp ppDyn mRNA, a gene coexpressed with the lat.hyp orexin. Our results show that there is an increase in MOP-r gene expression in a region-specific manner during morphine withdrawal, and support the hypothesis that increased lat.hyp orexin activity plays a role in morphine-withdrawal-related behaviors.

Acute intermittent morphine increases preprodynorphin and kappa opioid receptor mRNA levels in the rat brain

1999 ◽  
Vol 66 (1-2) ◽  
pp. 184-187 ◽  
Author(s):  
Xiao-Min Wang ◽  
Yan Zhou ◽  
Rudolph Spangler ◽  
Ann Ho ◽  
Ji-Shen Han ◽  
...  
Keyword(s):  
Rat Brain ◽  
Opioid Receptor ◽  
Kappa Opioid Receptor ◽  
Mrna Levels ◽  
Kappa Opioid ◽  
Receptor Mrna

Acute “binge” cocaine increases mu-opioid receptor mRNA levels in areas of the rat mesolimbic mesocortical dopamine system

1999 ◽  
Vol 48 (1) ◽  
pp. 109-112 ◽  
Author(s):  
Vadim Yuferov ◽  
Yan Zhou ◽  
Rudolph Spangler ◽  
Christopher E Maggos ◽  
Ann Ho ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Mu Opioid Receptor ◽  
Mrna Levels ◽  
Dopamine System ◽  
Mu Opioid ◽  
Receptor Mrna
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