scholarly journals Plasmacytoid Dendritic Cells: A New Cutaneous Dendritic Cell Subset with Distinct Role in Inflammatory Skin Diseases

2002 ◽  
Vol 119 (5) ◽  
pp. 1096-1102 ◽  
Author(s):  
Andreas Wollenberg ◽  
Sandra Günther ◽  
Martina Moderer ◽  
Stefanie Wetzel ◽  
Moritz Wagner ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Dendritic Cell ◽  
Skin Diseases ◽  
Cell Subset ◽  
Plasmacytoid Dendritic Cells ◽  
Dendritic Cell Subset ◽  
Inflammatory Skin Diseases ◽  
Inflammatory Skin ◽  
Distinct Role

scholarly journals Macrophage and dendritic cell subset composition can distinguish endotypes in adjuvant-induced asthma mouse models

2021 ◽  
Author(s):  
Müge Özkan ◽  
Yusuf Cem Eskiocak ◽  
Gerhard Wingender
Keyword(s):  
Dendritic Cells ◽  
Dendritic Cell ◽  
Mouse Models ◽  
Cell Subset ◽  
Clear Understanding ◽  
Dendritic Cell Subset ◽  
Myeloid Dendritic Cells ◽  
Differential Distribution ◽  
Eosinophilic Asthma ◽  
Effective Diagnosis

Asthma is a heterogeneous disease with neutrophilic and eosinophilic asthma as the main endotypes that are distinguished according to the cells recruited to the airways and the related pathology. Eosinophilic asthma is the treatment-responsive endotype, which is mainly associated with allergic asthma. Neutrophilic asthma is a treatment-resistant endotype, affecting 5-10% of asthmatics. Although eosinophilic asthma is well-studied, a clear understanding of the endotypes is essential to devise effective diagnosis and treatment approaches for neutrophilic asthma. To this end, we directly compared adjuvant-induced mouse models of neutrophilic (CFA/OVA) and eosinophilic (Alum/OVA) asthma side-by-side. The immune response in the inflamed lung was analyzed by multi-parametric flow cytometry and immunofluorescence. We found that eosinophilic asthma was characterized by a preferential recruitment of interstitial macrophages and myeloid dendritic cells, whereas in neutrophilic asthma plasmacytoid dendritic cells, exudate macrophages, and GL7 + activated B cells predominated. This differential distribution of macrophage and dendritic cell subsets reveals important aspects of the pathophysiology of asthma and holds the promise to be used as biomarkers to diagnose asthma endotypes.

CD8α+ mouse spleen dendritic cells do not originate from the CD8α- dendritic cell subset

Blood ◽  
2003 ◽  
Vol 102 (2) ◽  
pp. 601-604 ◽  
Author(s):  
Shalin Naik ◽  
David Vremec ◽  
Li Wu ◽  
Meredith O'Keeffe ◽  
Ken Shortman
Keyword(s):  
Dendritic Cells ◽  
Dendritic Cell ◽  
Balance Sheet ◽  
Rare Event ◽  
Cell Subset ◽  
Mouse Spleen ◽  
Dendritic Cell Subset

AbstractAlthough previous studies had indicated that the CD8α- and CD8α+ subtypes of murine dendritic cells (DCs) differ in immediate origin, a recent study found that intravenous transfer of CD8α- DCs led to CD8α+ DCs in the spleen several days later, suggesting a direct precursor-product relationship. We have repeated these experiments with a balance sheet approach. We find that though a few CD8α+ DCs can be generated in such experiments, this is a rare event and could be the result of a contaminant precursor. Most of the immediate precursors of CD8α+ DCs are cells that lack the phenotype of a recognizable DC. CD8α- DCs and CD8α+ DCs are not precursor-product related, though these sublineages may be connected further upstream.

scholarly journals Merocytic Dendritic Cells Compose a Conventional Dendritic Cell Subset with Low Metabolic Activity

2020 ◽  
Vol 205 (1) ◽  
pp. 121-132
Author(s):  
Cindy Audiger ◽  
Adrien Fois ◽  
Alyssa L. Thomas ◽  
Edith Janssen ◽  
Martin Pelletier ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Dendritic Cell ◽  
Metabolic Activity ◽  
Cell Subset ◽  
Dendritic Cell Subset

scholarly journals Role of the CD8+ Dendritic Cell Subset in Transmission of Prions

2007 ◽  
Vol 81 (9) ◽  
pp. 4877-4880 ◽  
Author(s):  
Shneh Sethi ◽  
Kristen M. Kerksiek ◽  
Thomas Brocker ◽  
Hans Kretzschmar
Keyword(s):  
Dendritic Cells ◽  
Dendritic Cell ◽  
Cell Subset ◽  
Transgenic Mouse Model ◽  
Oral Infection ◽  
Lymphoid Tissues ◽  
Dendritic Cell Subset ◽  
Prion Infection ◽  
Intraperitoneal Infection

ABSTRACT Controversial results have been observed in mouse models regarding the role of lymphoid tissues in prion pathogenesis. To investigate the role of dendritic cells (DC), we used a transgenic mouse model. In this model (CD11c-N17Rac1), a significant reduction of CD8+ CD11chi DC has been described, and the remaining CD8+ DC demonstrate a reduced capacity for the uptake of apoptotic cells. After intraperitoneal prion infection, significantly longer incubation times were observed in CD11c-N17Rac1 mice than in controls, indicating that a defect in CD8+ CD11chi DC significantly impedes neuroinvasion after intraperitoneal infection. In contrast, no distinct differences were observed between CD11c-N17Rac1 mice and controls after oral infection. This provides evidence that oral and intraperitoneal prion infections differ in lymphoreticular requirements.

scholarly journals Cytokine-Producing Dendritic Cells in the Pathogenesis of Inflammatory Skin Diseases

2009 ◽  
Vol 29 (3) ◽  
pp. 247-256 ◽  
Author(s):  
Leanne M. Johnson-Huang ◽  
N. Scott McNutt ◽  
James G. Krueger ◽  
Michelle A. Lowes
Keyword(s):  
Dendritic Cells ◽  
Skin Diseases ◽  
Inflammatory Skin Diseases ◽  
Inflammatory Skin

scholarly journals Expression and Function of the Mannose Receptor CD206 on Epidermal Dendritic Cells in Inflammatory Skin Diseases

2002 ◽  
Vol 118 (2) ◽  
pp. 327-334 ◽  
Author(s):  
Andreas Wollenberg ◽  
Tilmann Oppel ◽  
Eva-Maria Schottdorf ◽  
Sandra Günther ◽  
Martina Moderer ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Skin Diseases ◽  
Mannose Receptor ◽  
Inflammatory Skin Diseases ◽  
Inflammatory Skin ◽  
And Function ◽  
Epidermal Dendritic Cells

scholarly journals Human plasmacytoid dendritic cells are equipped with antigen-presenting and tumoricidal capacities

Blood ◽  
2012 ◽  
Vol 120 (19) ◽  
pp. 3936-3944 ◽  
Author(s):  
Jurjen Tel ◽  
Evelien L. Smits ◽  
Sébastien Anguille ◽  
Rubin N. Joshi ◽  
Carl G. Figdor ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Viral Infections ◽  
Cell Subset ◽  
Plasmacytoid Dendritic Cells ◽  
Type I Interferons ◽  
Human Interferon ◽  
Target Cells ◽  
Type I ◽  
Dendritic Cell Subset ◽  
Antigen Presenting

Abstract Human plasmacytoid dendritic cells (pDCs) represent a highly specialized naturally occurring dendritic-cell subset and are the main producers of type I interferons (IFNs) in response to viral infections. We show that human pDCs activated by the preventive vaccine FSME specifically up-regulate CD56 on their surface, a marker that was thought to be specific for NK cells and associated with cytolytic effector functions. We observed that FSME-activated pDCs specifically lysed NK target cells and expressed cytotoxic molecules, such as tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and granzyme B. Elevated levels of these molecules coincided with the expression of CD56, indicative for skewing human pDCs toward an interferon-producing killer DC subset. Detailed phenotypical and functional analysis revealed that pDCs attained a mature phenotype, secreted proinflammatory cytokines, and had the capacity to present antigens and stimulate T cells. Here, we report on the generation of CD56+ human interferon producing killer pDCs with the capacity to present antigens. These findings aid in deciphering the role for pDCs in antitumor immunity and present a promising prospect of developing antitumor therapy using pDCs.

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