CD8α+ mouse spleen dendritic cells do not originate from the CD8α- dendritic cell subset
Keyword(s):
AbstractAlthough previous studies had indicated that the CD8α- and CD8α+ subtypes of murine dendritic cells (DCs) differ in immediate origin, a recent study found that intravenous transfer of CD8α- DCs led to CD8α+ DCs in the spleen several days later, suggesting a direct precursor-product relationship. We have repeated these experiments with a balance sheet approach. We find that though a few CD8α+ DCs can be generated in such experiments, this is a rare event and could be the result of a contaminant precursor. Most of the immediate precursors of CD8α+ DCs are cells that lack the phenotype of a recognizable DC. CD8α- DCs and CD8α+ DCs are not precursor-product related, though these sublineages may be connected further upstream.
2021 ◽
Keyword(s):
2002 ◽
Vol 119
(5)
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pp. 1096-1102
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2004 ◽
Vol 77
(4)
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pp. 535-543
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2016 ◽
Vol 94
(5)
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pp. 447-457
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