High plasma renin activity is combined with elevated urinary albumin excretion in essential hypertensive patients

The aim of the research: to evaluate the effect of plasma renin activity on the state of hemodynamic and neurohumoral parameters in obese hypertensive patients. Anthropometric, biochemical, automated methods of immune analysis, spectrophotometric, instrumental, statistical methods were used to examine 200 hypertensive patients with class I–II obesity aged 45–55 years. Patients were divided into two groups depending on plasma renin activity: the first group included 21 patients with low-renin hypertension, the second – 179 patients with high-renin hypertension. Patients with HRAH had higher blood pressure BP (DBP, p = 0.004, SBP and mean blood pressure, p<0.001 for both indicators), higher CIMT bifurcation (p = 0.003) and cPWV (p = 0.023), larger size of the left ventricle and its MM (p = 0.039) compared with patients with LRAH. The HRAH was associated with a more pronounced imbalance of the oxidative stress system – antioxidant protection, higher levels of leptin, total cholesterol and LDL cholesterol. In the absence of differences in glycemic levels, patients with HRAH had significantly higher insulin levels and more pronounced IR, as assessed by the HOMA index. Patients with low plasma renin activity had significantly lower serum aldosterone levels with significantly higher ARR levels than patients with high plasma renin activity. Features of cardiovascular remodeling and neurohumoral status depending on the phenotype of hypertension in patients with concomitant obesity have been established.

Download Full-text

URINARY ALBUMIN EXCRETION-PREVALENCE IN HYPERTENSIVE PATIENTS IN SLOVENIA AND TELMISARTAN REDUCTION EFFECT

Journal of Hypertension ◽

10.1097/00004872-201106001-01260 ◽

2011 ◽

Vol 29 ◽

pp. e422

Author(s):

J. Brguljan ◽

R. Accetto ◽

B. Salobir ◽

P. Dolenc

Keyword(s):

Urinary Albumin Excretion ◽

Urinary Albumin ◽

Hypertensive Patients ◽

Albumin Excretion ◽

Reduction Effect

Download Full-text

Inappropriately High Plasma Renin Activity Accompanies Chronic Loss of Renal Function

American Journal of Nephrology ◽

10.1159/000169046 ◽

1996 ◽

Vol 16 (6) ◽

pp. 471-477 ◽

Cited By ~ 8

Author(s):

Nesmo L. Yeyati ◽

Horacio J. Adrogué

Keyword(s):

Renal Function ◽

Plasma Renin Activity ◽

Plasma Renin ◽

High Plasma ◽

Renin Activity

Download Full-text

Effect of temperature on plasma renin samples.

Clinical Chemistry ◽

10.1093/clinchem/24.7.1202 ◽

1978 ◽

Vol 24 (7) ◽

pp. 1202-1204 ◽

Cited By ~ 13

Author(s):

F Fyhrquist ◽

L Puutula

Keyword(s):

Plasma Renin Activity ◽

Room Temperature ◽

Plasma Renin ◽

Renin Activity ◽

Effect Of Temperature ◽

Plasma Samples ◽

Hypertensive Patients ◽

Variable Extent ◽

Venous Plasma

Abstract Plasma renin activity was measured in parallel in Na2EDTA-contained plasma samples after storage at -20, 4, and 24 degrees C, and in the lyophilized state. In peripheral venous plasma from 22 hypertensive patients, the activity (range, 0.08-46.7 microgram/liter per hour) remained stable during three days of storage at 4 degrees C, but decreased to a variable extent when plasma was kept at 24 degrees C: in one day by 9.2%, two days by 25.6%, and three days by 74.0%. Values were the same for samples handled at room temperature and chilled to 4 degrees C within 3 h and parallel samples immediately cooled in an icebath and kept at 4 degrees C. Freezing (-20 degrees C) and thawing of plasma was associated with a 22% mean increase in activity (range, 0-83%). Lyophilization resulted in a smaller increase of plasma renin activity (mean 12%, range 0-46%). Blood for renin analysis need not be cooled immediately, but must be cooled to 4 degrees C within 2-3 h. It then is stabe for at least three days. Freezing or lyophilization appears to be associated with some cold activation of "prorenin."

Download Full-text

Activity Assays and Immunoassays for Plasma Renin and Prorenin: Information Provided and Precautions Necessary for Accurate Measurement

Clinical Chemistry ◽

10.1373/clinchem.2008.118000 ◽

2009 ◽

Vol 55 (5) ◽

pp. 867-877 ◽

Cited By ~ 109

Author(s):

Duncan J Campbell ◽

Juerg Nussberger ◽

Michael Stowasser ◽

A H Jan Danser ◽

Alberto Morganti ◽

...

Keyword(s):

Plasma Renin Activity ◽

Plasma Renin ◽

Inhibitor Therapy ◽

Renin Activity ◽

Renin Inhibitor ◽

Blood Samples ◽

Hypertensive Patients ◽

Active Renin ◽

Open Conformation ◽

Background Measurement

AbstractBackground: Measurement of plasma renin is important for the clinical assessment of hypertensive patients. The most common methods for measuring plasma renin are the plasma renin activity (PRA) assay and the renin immunoassay. The clinical application of renin inhibitor therapy has thrown into focus the differences in information provided by activity assays and immunoassays for renin and prorenin measurement and has drawn attention to the need for precautions to ensure their accurate measurement.Content: Renin activity assays and immunoassays provide related but different information. Whereas activity assays measure only active renin, immunoassays measure both active and inhibited renin. Particular care must be taken in the collection and processing of blood samples and in the performance of these assays to avoid errors in renin measurement. Both activity assays and immunoassays are susceptible to renin overestimation due to prorenin activation. In addition, activity assays performed with peptidase inhibitors may overestimate the degree of inhibition of PRA by renin inhibitor therapy. Moreover, immunoassays may overestimate the reactive increase in plasma renin concentration in response to renin inhibitor therapy, owing to the inhibitor promoting conversion of prorenin to an open conformation that is recognized by renin immunoassays.Conclusions: The successful application of renin assays to patient care requires that the clinician and the clinical chemist understand the information provided by these assays and of the precautions necessary to ensure their accuracy.

Download Full-text

Sodium and Renin in the Hypertension of Early Renal Disease

Clinical Science ◽

10.1042/cs055301s ◽

1978 ◽

Vol 55 (s4) ◽

pp. 301s-303s ◽

Cited By ~ 4

Author(s):

S. F. Wong ◽

M. I. Mitchell ◽

V. Robson ◽

R. Wilkinson

Keyword(s):

Blood Pressure ◽

Renal Disease ◽

Plasma Renin Activity ◽

Plasma Renin ◽

Renin Activity ◽

Exchangeable Sodium ◽

Hypertensive Patients ◽

Body Build ◽

Activity Response ◽

Normal Controls

1. Plasma renin activity, response to saralasin and exchangeable sodium have been measured in 43 patients with early renal disease. 2. Blood pressure was directly proportional to plasma renin activity. However, mean plasma renin activity was lower in patients with renal disease than in normal controls. 3. Blood pressure fell in response to saralasin infusion in proportion to the pre-infusion plasma renin activity. 4. Exchangeable sodium in hypertensive patients with renal disease did not exceed that in normotensive patients in contrast to earlier reports. Discrepancies may arise from the difficulty in interpreting measured exchangeable sodium in relation to body build.

Download Full-text