Diagnostic markers in the aspect of the development of HIV-encephalopathy in children

The aim of the study was to evaluate the diagnostic markers in children with HIV —encephalopathy (HIVE) with varying degrees of severity.Material and methods of research: The study included 260 children (153 boys — 58.85% and 107 girls —41.7%) with HIV-positive status and receiving antiretroviral therapy according to an individually selected scheme for at least 6 months. All children included in the study showed signs of HIV encephalopathy. The activity response was assessed by the concentration of IL-6, IL-10, TNF-alpha, C-reactive protein, C3, C4 components of the complement (immunofelometric analysis).Results: The study of the activity response in children with HIV encephalopathy found that the concentration of TNF —alpha and IL-6 were increased, compared, to the reference values (12.67±0.25 PG/ml and 23.04±0.64 PG/ml, respectively, with reference values of less than 8.1 PG/ml and 7pg/ml, respectively), and the concentration of IL-10 was reduced (5.93±0.10 PG/ml with a reference value of more than 9.1 PG/ml). The study analyzed the predictor significance of various parameters response in the aspect of the development of symptomatic HIV- encephalopathy. A comparative analysis of the concentration markers was performed, and the incidence of symptomatic HIV —encephalopathy was determined depending on the diagnostic concentration of the diagnostic marker. This finding is probably explained by the effector role of systemic inflammation in the development of damage to the Central nervous system.Conclusion. The maximum predictor significance in the aspect of the development of symptomatic HIV -encephalopathy was found in proinflammatory cytokines: an increase in IL-6 concentration above 19.6 PG / ml is associated with an increase in the risk of developing symptomatic HIV encephalopathy by 9.14 times, and an increase in TNF -alpha concentration above 12.5 PG/ml by 4.07 times (p<0.001 for both factors).

The activity in sociocultural and natural environment.

This article examines the ontology of activity. Such need emerged due to the problems in studying of modern technology. It is evident that an engineer and a technologist work in a complex environment and conditioned by different situation, but the theoretical representations of the activity do account for these circumstances. The author explores the traditional view and scenario. Analysis is conducted on the several situations (environmental, anthropological, cultural, social, population) that impact the work and mentality of an engineer and a technologist. A new pattern of an act is proposed. In the course of research, the author employs the following methodology: articulation of the problem, situational and comparative analysis, typological analysis, structuring of the narrative scheme of activity. As a result, the author was able to describe the situation that requires reconsideration of the ontology of activity. It is necessary to reveal the differences of several spheres, which are important from environmental, anthropological, cultural, social, and population perspectives. The article outlines the scheme of activity, which includes a new interpretation of the subject of activity, several processes launched by pursuit of the activity, response from these processes to articulation of goals and tasks of the activity.