Surgery and prognosis in stage III epithelial ovarian cancer

1995 ◽  
Vol 5 (6) ◽  
pp. 416-420 ◽  
Author(s):  
G. Ing ◽  
N. Semrad ◽  
S. Jordan ◽  
F. Latino ◽  
W. G. Watring
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Tumor Grade ◽  
Stage Iii ◽  
Retrospective Case ◽  
Second Look ◽  
Significant Difference ◽  
Grade 3 ◽  
Retrospective Case Study

The results of this retrospective case study indicate that a composite of tumor grade, pattern of spread and substage at the time of opening affects the outcome most in the treatment of stage III epithelial tumors of the ovary. The poorest prognosis was associated with grade 3 histology, a pattern of spread requiring extensive and often difficult surgery for removal and a high substage. The best prognosis was usually associated with grade 1, with either very easily removed, isolated spread or low substage.The extent of tumor defined the degree of primary cytoreduction possible. If the tumor was minimally extensive, primary cytoreduction results were excellent. The same conclusions were reached in the case of secondary cytoreduction at the time of second-look procedure. There was no statistically significant difference (z= 1.481,P= 0.069) in 5-year survival between patients with microscopic only disease (59%) at second-look, and patients with gross disease not cytoreduced (36%).

Intraperitoneal Radioactive Phosphorus (32P) Versus Observation After Negative Second-Look Laparotomy for Stage III Ovarian Carcinoma: A Randomized Trial of the Gynecologic Oncology Group

2003 ◽  
Vol 21 (15) ◽  
pp. 2849-2855 ◽  
Author(s):  
Mahesh A. Varia ◽  
Frederick B. Stehman ◽  
Brian N. Bundy ◽  
Jo Ann Benda ◽  
Daniel L. Clarke-Pearson ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Relative Risk ◽  
Ovarian Carcinoma ◽  
Tumor Recurrence ◽  
Stage Iii ◽  
Gynecologic Oncology Group ◽  
Consolidation Therapy ◽  
Risk Of Death ◽  
Second Look ◽  
Significant Difference

Purpose: The objectives of this prospective randomized study of consolidation therapy were to evaluate recurrence-free survival (RFS), overall survival (OS), and the morbidity of intraperitoneal (IP) chromic phosphate suspension (32P) therapy in patients with stage III epithelial ovarian carcinoma who have no detectable evidence of disease at the second-look laparotomy (SLL) procedure after primary chemotherapy. Patients and Methods: In a multi-institution clinical cooperative trial, 202 eligible patients with a negative SLL were randomly selected to receive either 15 mCi IP 32P (n = 104) or no further therapy (NFT; n = 98). Results: With a median follow-up of 63 months in living patients, 68 patients in the IP 32P group (65%) and 63 patients in the NFT group (64%) have developed tumor recurrence. The relative risk of recurrence is 0.90 (IP 32P to NFT) (90% confidence interval [CI], 0.68 to 1.19). The 5-year RFS rate is 42% and 36% for the IP 32P and NFT groups, respectively; the difference is not statistically significant (log-rank test, P = .27). There was no statistically significant difference in OS (P = .19). The relative risk of death is 0.85 (IP 32P to NFT) (90% CI, 0.62 to 1.16). Sixteen patients (8%) experienced grade 3 or 4 adverse effects, with eight in each respective group. Conclusion: Intraperitoneal chromic phosphate did not decrease the risk of relapse or improve survival for patients with stage III epithelial ovarian cancer after a negative SLL. Despite complete pathologic remission at SLL after initial surgery and platinum-based chemotherapy, 61% of stage III ovarian cancer patients had tumor recurrence within 5 years of negative SLL. This indicates a need for more effective initial therapy and further studies of consolidation therapy.

scholarly journals Epidemiological study of food poisoning during the period 2001-2018 in the province of Kenitra

2021 ◽  
Vol 319 ◽  
pp. 01055
Author(s):  
Asmaa Elkhal ◽  
Benaissa Attarassi ◽  
Nabila Aujjar ◽  
Samira Jayche ◽  
Mohamed Lahmam
Keyword(s):  
Public Health ◽  
Age Groups ◽  
Food Poisoning ◽  
Economic Aspects ◽  
Foodborne Illnesses ◽  
Retrospective Case ◽  
Female Predominance ◽  
Significant Difference ◽  
Retrospective Case Study

Foodborne illnesses can be the cause of morbidity or mortality. Collective foodborne illnesses (TIAC) are generally benign; their epidemic nature can have a significant impact in terms of public health and socio-economic aspects. The present study intends to establish a database inherent to food poisoning specific to the province of Kenitra during the period 2001-2018. These data will help inform about the current situation and the epidemiological evolution during the summer seasons of the study period. This is a retrospective case study of collective food poisoning. The consulted files include data relating to the number and characteristics of intoxicated persons in the study area, the seriousness of the cases (hospitalization, death), food and germ in question, and the factors that promote such an outbreak. The results show that, between 2001 and 2018, 43 outbreaks of TIAC were notified in the province of Kenitra, involved 367 patients (69 hospitalized and 2 deaths). The gender distribution of our sample shows a female predominance (sex ratio M/F = 0.65) with significant difference (p <0.01) (60.66% F; 39.34% M), and the age groups varied from 5 to + 30 years old of which 71.39% are under 25 years old.

Prognostic significance of p53 immunostaining in epithelial ovarian cancer.

1994 ◽  
Vol 12 (1) ◽  
pp. 64-69 ◽  
Author(s):  
L C Hartmann ◽  
K C Podratz ◽  
G L Keeney ◽  
N A Kamel ◽  
J H Edmonson ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Multivariate Analysis ◽  
Epithelial Ovarian Cancer ◽  
Univariate Analysis ◽  
Prognostic Significance ◽  
Stage I ◽  
Stage Iii ◽  
P53 Expression ◽  
Independent Prognostic Significance ◽  
Grade 3

PURPOSE To evaluate the prognostic significance of p53 expression in epithelial ovarian cancer, including a subset of stage I patients, and to look for correlations between p53 expression and other disease parameters, including stage, grade, age, histologic subtype, second-look results, ploidy, and percent S phase. PATIENTS AND METHODS We analyzed p53 expression in 284 patients with epithelial ovarian cancer using immunohistochemical techniques in paraffin-embedded specimens. There were 36 patients with stage I disease, 20 with stage II disease, 186 with stage III disease, and 42 with stage IV disease. RESULTS p53 immunoreactivity was present in 177 cases (62%). p53 expression was associated with grade 3 to 4 disease (P = .003). The following factors were associated with a decrease in overall survival in a univarate analysis: stage III or IV disease (P = .0001), grade 3 or 4 disease (P = .0001), age above the median (P = .0002), and p53 reactivity (P = .04). In a multivariate analysis, stage, grade, and age retained independent prognostic significance. In the subset of 36 stage I patients, p53 positively approached statistical significance (P = .10) as a negative prognostic factor in a univariate analysis. CONCLUSION Abnormalities of p53 expression occur commonly in epithelial ovarian cancer. Although associated with decreased survival in a univariate analysis, this biologic marker did not retain independent prognostic significance in a multivariate analysis. p53 expression should be studied in a larger cohort of early-stage patients, where accurate prognostic information is needed to direct therapy.

Second-Look Laparotomy in Stage III Epithelial Ovarian Cancer

1986 ◽  
pp. 183-188 ◽  
Author(s):  
J. S. Berek ◽  
N. F. Hacker ◽  
L. D. Lagasse ◽  
T. Poth ◽  
B. Resnick ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Stage Iii ◽  
Second Look

Second-look laparotomy for stage III epithelial ovarian cancer: rationale and current issues

1995 ◽  
Vol 21 (6) ◽  
pp. 499-511 ◽  
Author(s):  
Laila Muderspach ◽  
Franco M. Muggia ◽  
Peter S. Conti
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Stage Iii ◽  
Second Look
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