Association Between Dementia and Midlife Risk Factors: the Radiation Effects Research Foundation Adult Health Study

Abdominal ultrasonographic screening for cancer was performed in 6001 Hiroshima and Nagasaki A-bomb exposed and comparison subjects, all members of the Adult Health Study of the Radiation Effects Research Foundation, formerly the Atomic Bomb Casualty Commission. This study yielded 20 cancers, including 7 hepatocellular, 3 gastric, 3 renal and 2 urinary bladder cancers; one cancer each of the ovary, pancreas, colon and ureter; and one cancer metastatic to the liver, whose primary was unknown. Seventeen of these 20 subjects manifested no symptoms or signs of their disease. A variety of additional tumors, unproven and probably benign, including uterine myomata, and other abnormalities were also detected. Abdominal ultrasonographic screening greatly assisted in the detection of cancers, most of which neither the patients nor their physicians were aware. In this screened fixed population sample the cancer detection rate was 0.33%, exceeding any such rates previously reported in the medical literature.

Download Full-text

Exposure to cardiovascular disease risk factors in childhood is associated with increased carotid extra medial thickness in adulthood: The childhood determinants of adult health study

Atherosclerosis ◽

10.1016/j.atherosclerosis.2016.07.268 ◽

2016 ◽

Vol 252 ◽

pp. e12

Author(s):

H. West ◽

M. Skilton ◽

B. Fraser ◽

T. Dwyer ◽

A. Venn ◽

...

Keyword(s):

Risk Factors ◽

Cardiovascular Disease ◽

Disease Risk ◽

Cardiovascular Disease Risk ◽

Cardiovascular Disease Risk Factors ◽

Health Study ◽

Adult Health

Download Full-text

P3-121 Incidence of dementia in a Japanese population: the radiation effects research foundation adult health study

Neurobiology of Aging ◽

10.1016/s0197-4580(04)81273-9 ◽

2004 ◽

Vol 25 ◽

pp. S389-S390

Author(s):

Michiko Yamada ◽

Yasuyo Mimori ◽

Fumiyoshi Kasag ◽

Hideo Sasaki ◽

Takafumi Miyachi ◽

...

Keyword(s):

Japanese Population ◽

Radiation Effects ◽

Health Study ◽

Adult Health ◽

Incidence Of Dementia

Download Full-text

Th-W58:3 Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: The childhood determinants of adult health study

Atherosclerosis Supplements ◽

10.1016/s1567-5688(06)81931-8 ◽

2006 ◽

Vol 7 (3) ◽

pp. 483-484

Author(s):

C.G. Magnussen ◽

A. Venn ◽

T. Dwyer ◽

O.T. Raitakari

Keyword(s):

Risk Factors ◽

Cardiovascular Risk ◽

Carotid Artery ◽

Cardiovascular Risk Factors ◽

Intima Media Thickness ◽

Health Study ◽

Adult Health ◽

Media Thickness

Download Full-text

Abstract P183: Contribution Of Childhood Risk Factors To Sex Differences In Adult Carotid Imt And Plaques: The Childhood Determinants Of Adult Health Study

Circulation ◽

10.1161/circ.143.suppl_1.p183 ◽

2021 ◽

Vol 143 (Suppl_1) ◽

Author(s):

Mohammad Shah ◽

Jing Tian ◽

Marie-Jeanne BUSCOT ◽

Hoang T Phan ◽

Costan Magnussen ◽

...

Keyword(s):

Risk Factors ◽

Sex Differences ◽

Sex Difference ◽

Model Building ◽

School Achievement ◽

Psychosocial Health ◽

Health Study ◽

Adult Health ◽

Carotid Imt ◽

Childhood Risk Factors

Background: Understanding the origins of sex differences in cardiovascular diseases (CVD) may help with prevention. We examined sex differences in carotid artery IMT and plaques in adulthood including the contribution of childhood risk factors. Methods: Boys and girls aged 7-15 years old from the Australian Schools Health and Fitness Survey in 1985 were followed up in the Childhood Determinants of Adult Health study at ages 36-49 years between 2014-19. Sex differences in adult carotid IMT and plaques, identified with 2D ultrasound of left and right carotid arteries, were examined with linear and log binomial regression, respectively. Childhood sociodemographic, psychosocial, health-related behavioural and biomedical risk factors that might contribute to sex differences in carotid IMT/plaques were identified with purposeful model building. Results: Among 1,286 men and women with vascular measurements of carotid IMT (53% women, mean carotid IMT 0.63 mm ± 0.09 standard deviation) women had thinner carotid IMT measurements than men (β coefficients -0.053 95% CI -0.063, -0.043). Adjusting for age standardised waist circumference (WC), waist/hip ratio (WHR), waist/height ratio (WHtR) and systolic blood pressure (SBP) in childhood reduced the sex difference of carotid IMT in adulthood (see Figure), but a significant sex-difference in carotid IMT remained. Women had a 42% lower risk of plaques than men (Relative Risk 0.58 95% CI 0.42, 0.79). School achievement levels, endurance/power fitness and SBP in childhood partially explained the sex difference in the prevalence of plaques at adulthood (see Figure) as the sex difference decreased and became statistically insignificant. Conclusion: Various factors in childhood had contributed to thicker carotid IMT and higher prevalence of carotid plaques in men compared to women. These findings suggest that the origins of adult sex differences in CVD may begin in childhood. There may be benefits of sex-specific primary prevention programs starting in childhood.

Download Full-text