Aiming at the phenomenon that the chaff and corner reflector released by surface ship can influence the selection of missile seeker, this paper proposed a multi-target selection method based on the prior information of false targets distribution and Support Vector Machine (SVM). By analyzing the false targets distribution law we obtain two classification principles, which are used to train the SVM studies the true and false target characteristics. The trained SVM is applied to the seeker in the target selection. This method has advantages of simple programming and high classification accuracy, and the simulation experiment in this paper confirms the correctness and effectiveness of this method.