scholarly journals Pulmonary alveolar microlithiasis and interstitial pneumonitis: a case report of the west of Iran

BioMedicine ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 28
Author(s):  
Mazaher Ramezani ◽  
Zahra Aminparast ◽  
Masoud Sadeghi

Pulmonary alveolar microlithiasis (PAM) is a rare disease with autosomal recessive inheritance. Herein, a 20-year-old lady referred to the hospital with a dry cough for two years. The chest X-ray findings were bilateral reticulonodular opacities in both lungs and honeycomb appearance suspicious for miliary tuberculosis and idiopathic pulmonary fibrosis. A wedge biopsy of lung showed that there were several intraalveolar laminated concretions in the pathology report compatible with pulmonary alveolar microlithiasis and interstitial infiltration of lymphocytes and neutrophils compatible with interstitial pneumonitis. PAM is a rare progressive disease with the production of microliths in pulmonary alveoli. The pathologist, radiologist, and clinician should be familiar with this entity for diagnosis and appropriate management. The family of the patient especially siblings must be evaluated for earlier diagnosis.

2011 ◽  
Vol 12 (1) ◽  
pp. 55-57 ◽  
Author(s):  
Balasubramaniam Gayathri ◽  
Sivanmani Keerthivasan

Pulmonary alveolar microlithiasis (PAM) is a rare idiopathic disease characterized by microliths in the lungs which is usually asymptomatic and often diagnosed incidentally. Here we discuss a case of a young woman while evaluating for surgery presented with an abnormal chest X ray of bilateral diffuse nodular opacities. Patient was completely asymptomatic. High resolution CT scan revealed crazy paving pattern, black pleura sign, and pleural calcification typical findings of pulmonary alveolar microlithiasis. CT guided lung biopsy confirmed the diagnosis. Keyword: Black pleura sign; calcium deposition; crazy paving pattern; pulmonary alveolar microlithiasis DOI: 10.3329/jom.v12i1.6111J Medicine 2011; 12 : 55-57


2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Preethi Dileep Menon ◽  
Sarah Hackman

Pulmonary alveolar microlithiasis (PAM) is an uncommon hereditary lung disease characterized by widespread deposition of calcium phosphate microliths within the alveolar spaces. It is considered an autosomal recessive disease with a mutation in a gene encoding a sodium phosphate cotransporter. The imaging findings in the early phase of disease can be mistaken for miliary tuberculosis or sarcoidosis. However, the classic radiologic findings in the later phases of disease show numerous opacities causing a “snowstorm” appearance to the lungs that corresponds with widespread deposition of microliths throughout the lung parenchyma. Although the disease often progresses over a slow time course, there are no effective therapies, and bilateral lung transplantation is recommended when there are increasing oxygen requirements or evidence of pulmonary hypertension.


1982 ◽  
Vol 7 (3) ◽  
pp. 103-107 ◽  
Author(s):  
CHOHEI SHIGENO ◽  
MASAO FUKUNAGA ◽  
RIKUSHI MORITA ◽  
HISATOSHI MAEDA ◽  
MEGUMU HINO ◽  
...  

1968 ◽  
Vol 103 (3) ◽  
pp. 509-518 ◽  
Author(s):  
JIRAYR P. BALIKIAN ◽  
FARID J. D. FULEIHAN ◽  
CHARLES N. NUCHO

1980 ◽  
Vol 24 (1) ◽  
pp. 24-26
Author(s):  
B. RAMA RAO ◽  
MICHAEL B. MARTIN

1998 ◽  
Vol 7 (3) ◽  
pp. 324
Author(s):  
Akihiko Kimura ◽  
T Matsuyama ◽  
J Takada ◽  
S Ishii ◽  
M Usui

2021 ◽  
Vol 14 (3) ◽  
pp. e237580
Author(s):  
Jacob Kilgore ◽  
Jonathon Pelletier ◽  
Bradford Becken ◽  
Stephen Kenny ◽  
Samrat Das ◽  
...  

We present a 16-year-old girl with a history of well-controlled psoriasis, on immunosuppression, who sought evaluation in the emergency department for 4 months of fever, cough and unintentional weight loss. The patient had seen multiple providers who had diagnosed her with community-acquired pneumonia, but she was unimproved after oral antibiotic therapy. On presentation, she was noted to be febrile, tachycardic and chronically ill-appearing. Her chest X-ray showed diffuse opacities and a right upper lobe cavitary lesion concerning for tuberculosis. A subsequent chest CT revealed miliary pulmonary nodules in addition to the cavitary lesion. The patient underwent subsequent brain MRI, which revealed multifocal ring-enhancing nodules consistent with parenchymal involvement. The patient was diagnosed with miliary tuberculosis and improved on quadruple therapy. Though rates of tuberculosis are increasing, rates remain low in children, though special consideration should be given to children who are immunosuppressed.


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