scholarly journals Efficacy of a novel topical combination of esafoxolaner, eprinomectin and praziquantel against adult cat flea Ctenocephalides felis and flea egg production in cats

Parasite ◽  
2021 ◽  
Vol 28 ◽  
pp. 21 ◽  
Author(s):  
Eric Tielemans ◽  
Prescillia Buellet ◽  
David Young ◽  
Alta Viljoen ◽  
Julian Liebenberg ◽  
...  
Keyword(s):  
Egg Production ◽  
Experimental Studies ◽  
Ctenocephalides Felis ◽  
Control Group ◽  
Placebo Control ◽  
Immature Stages ◽  
The Novel ◽  
Cat Flea ◽  
Larval Hatching ◽  
Adult Cat

Esafoxolaner, a purified enantiomer of afoxolaner with insecticidal and acaricidal properties, is combined with eprinomectin and praziquantel in NexGard® Combo, a novel topical endectoparasiticide formulation for cats. The efficacy of this novel formulation against adult and immature stages of Ctenocephalides felis fleas was tested in four experimental studies. Two studies were designed to test adulticide efficacy, one to test inhibition of immature stages, and one to test both adulticide efficacy and inhibition of immature stages. In each study, cats were randomly allocated to a placebo control group or to a novel formulation group treated once at the minimum recommended dose. Cats were experimentally infested weekly for one to two months with unfed C. felis originating from North America or Europe. For adulticide efficacy evaluations, live fleas were counted 24 h after treatment and after subsequent weekly infestations. For immature stages, flea eggs were collected and counted weekly for evaluation of egg production inhibition and incubated for larval hatching evaluation. In the three studies testing adult fleas, curative efficacies, 24 h after treatment, were 92.1%, 98.3% and 99.7%; preventive weekly efficacies, 24 h after weekly infestations, remained higher than 95.5% for at least one month. In the two studies testing immature stages, egg production and larval hatching was significantly reduced for at least one month. These studies provide robust evidence of efficacy of the novel formulation against experimental adult flea infestations and for the prevention of environmental contamination by immature flea stages, for at least one month.

scholarly journals Efficacy of a novel topical combination of esafoxolaner, eprinomectin and praziquantel against Ixodes ricinus and Ixodes scapularis in cats

Parasite ◽  
2021 ◽  
Vol 28 ◽  
pp. 23 ◽  
Author(s):  
Joe Prullage ◽  
Anthony Pfefferkorn ◽  
Martin Knaus ◽  
Justin Frost ◽  
Elizabeth Mitchell ◽  
...  
Keyword(s):  
Ixodes Ricinus ◽  
Ixodes Scapularis ◽  
Experimental Studies ◽  
Control Group ◽  
Placebo Control ◽  
The Novel ◽  
Topical Formulation ◽  
Arithmetic Means ◽  
Pre Treatment ◽  
Robust Evidence

Esafoxolaner is a purified enantiomer of afoxolaner with insecticidal and acaricidal properties. It is combined with eprinomectin and praziquantel in a novel topical endectoparasiticide formulation for cats. The efficacy of this novel formulation was evaluated in three Ixodes ricinus and two Ixodes scapularis experimental studies, with comparable designs. In each study, cats were randomly allocated, based on a pre-treatment tick infestation and count, to a placebo control group or a group treated with the minimum recommended dose of the novel formulation. Cats were infested two days before treatment and weekly thereafter. Immediate efficacy was evaluated 48 h after treatment; persistent efficacy was evaluated 48 h after new weekly infestations for at least one month after the treatment (in one of the studies, the first two weeks of persistent efficacy against I. ricinus were not tested). Efficacy was calculated at each timepoint by comparison of arithmetic means of live ticks found in the control and the treated groups. In the three studies targeting I. ricinus, immediate and persistent efficacies ranged between 91% and 100% for five weeks. In the two studies targeting I. scapularis, immediate and persistent efficacies ranged between 95% and 100%, and 98% and 100% for one month, respectively. These studies provide robust evidence of efficacy of the novel topical formulation of esafoxolaner, eprinomectin and praziquantel against experimental I. ricinus and I. scapularis infestations for at least one month in cats.

scholarly journals Efficacy of a novel topical combination of esafoxolaner, eprinomectin and praziquantel against Echinococcus multilocularis infections in cats

Parasite ◽  
2021 ◽  
Vol 28 ◽  
pp. 29
Author(s):  
Joe Prullage ◽  
Dwight Bowman ◽  
Michael Ulrich ◽  
Eric Tielemans
Keyword(s):  
Echinococcus Multilocularis ◽  
Experimental Studies ◽  
The United States ◽  
Treated Group ◽  
Control Group ◽  
Placebo Control ◽  
The Novel ◽  
Control Groups ◽  
Geometric Means ◽  
Placebo Control Group

NexGard® Combo, a novel topical endectoparasiticide formulation for cats combining esafoxolaner, eprinomectin and praziquantel, for the treatment of internal and external parasite infestations, including arthropods, nematodes and cestodes, was tested for efficacy against induced infections of Echinococcus multilocularis in cats, in two experimental studies. The two studies were performed in the United States with the same E. multilocularis isolate sourced locally. In each study, 20 cats were inoculated intra-gastrically with ~30,000 E. multilocularis protoscoleces three weeks before treatment, then ten cats were randomly allocated to a placebo control group or to the novel formulation treated group. Inoculated cats were treated topically once at the minimum recommended dose of the novel formulation, or with an identical volume of placebo. One week after treatment, cats were humanely euthanized for parasite recovery and count. The efficacy calculation was based on comparison of number of scoleces found in the control group and the novel formulation group. In the two control groups, E. multilocularis scoleces were found in five (range: 30–1025) and eight (range 2–345) cats, the geometric means inclusive of the ten cats per group were 8.9 and 28.8, respectively. In the two novel formulation-treated groups, none of the cats harbored any E. multilocularis scoleces, demonstrating 100% efficacy.

scholarly journals Efficacy of a novel topical combination of esafoxolaner, eprinomectin and praziquantel against Amblyomma americanum in cats

Parasite ◽  
2021 ◽  
Vol 28 ◽  
pp. 25 ◽  
Author(s):  
Joe Prullage ◽  
Christine Baker ◽  
Abdelmoneim Mansour ◽  
Scott McCall ◽  
David Young ◽  
...  
Keyword(s):  
Experimental Studies ◽  
The United States ◽  
Treated Group ◽  
Amblyomma Americanum ◽  
Control Group ◽  
Placebo Control ◽  
The Novel ◽  
Tick Count ◽  
Placebo Control Group ◽  
Preventive Efficacy

Esafoxolaner, a purified enantiomer of afoxolaner with insecticidal and acaricidal properties, is combined with eprinomectin and praziquantel in NexGard® Combo, a novel topical endectoparasiticide product for cats. The efficacy of this novel formulation was assessed in two experimental studies against induced infestations with Amblyomma americanum, a tick species of major importance, highly prevalent in a large southeastern quarter of the United States. In each study, 10 cats were randomly allocated to a placebo control group and 10 cats to a novel formulation treated group. Infested cats were treated topically once at the minimum recommended dose. Both studies were designed to test curative efficacy on existing infestation, 72 h after treatment, and to test preventive efficacy, 72 h after subsequent weekly (Study #1) or fortnightly (Study #2) infestations for one month. For each infestation, all cats were infested with 50 unfed adult A. americanum. At each tick count, in both studies, at least 8 in 10 placebo control cats were infested with 13 (26%) or more live ticks, demonstrating adequate infestation throughout the studies. Curative efficacy of the novel formulation was 99% in both studies; preventive efficacy was 92% and 100% for at least one month.

scholarly journals Control of immature stages of the flea Ctenocephalides felis(Bouché) in carpets exposed to cats treated with imidacloprid

2000 ◽  
Vol 71 (4) ◽  
Author(s):  
L.J. Fourie ◽  
D.J. Kok ◽  
R.J. Peter
Keyword(s):  
Untreated Control ◽  
Ctenocephalides Felis ◽  
Immature Stages ◽  
Cat Flea ◽  
Allergic Dermatitis ◽  
Marked Inhibition ◽  
Eggs And Larvae ◽  
Adult Flea

Fleas cause allergic dermatitis in cats and dogs and therefore warrant control. It has been demonstrated previously that there is marked inhibition of the development of the immature stages of the cat flea Ctenocephalides felis on fleece blankets exposed to cats treated with imidacloprid. This study reports on the efficacy of imidacloprid in suppressing adult flea emergence in carpet exposed to treated cats. Circular discs of carpet pre-seeded with flea eggs and larvae were exposed to 6 untreated control and 6 topically treated (imidacloprid 10 % m/v) cats 1 to 2 days after treatment and subsequently fortnightly for 6 weeks. Exposure times on alternate days were either 1 or 6 hours. Adult flea yield from carpets was determined 35 days after exposure. Differences between flea yield on control carpets and those exposed for 1 hour were significant only for days +1 and +14. For the 6-hour exposure, differences were significant at all times except on Day +43. The ability of imidacloprid to suppress the yield of adult fleas on carpets (6-hour exposure) steadily declined from 82 % (Day +2) to 12 %(Day +43). For the 1-hour exposure it varied inconsistently between 0 and 83 % over the 6-week study period.

scholarly journals Efficacy of indoxacarb applied to cats against the adult cat flea, Ctenocephalides felis, flea eggs and adult flea emergence

2013 ◽  
Vol 6 (1) ◽  
Author(s):  
Michael W Dryden ◽  
Patricia A Payne ◽  
Vicki Smith ◽  
Kathleen Heaney ◽  
Fangshi Sun
Keyword(s):  
Ctenocephalides Felis ◽  
Cat Flea ◽  
Adult Cat ◽  
Adult Flea

scholarly journals The efficacy of a topically applied combination of cyphenothrin and pyriproxyfen against the southern African yellow dog tick, Haemaphysalis elliptica, and the cat flea, Ctenocephalides felis, on dogs

2010 ◽  
Vol 81 (1) ◽  
Author(s):  
J. J. Fourie ◽  
L. J. Fourie ◽  
I. G. Horak ◽  
M. G. Snyman
Keyword(s):  
Untreated Control ◽  
Treated Group ◽  
Ctenocephalides Felis ◽  
Control Group ◽  
Untreated Control Group ◽  
Geometric Means ◽  
Cat Flea ◽  
Haemaphysalis Elliptica ◽  
Residual Efficacy ◽  
Dog Tick

The objective of this study was to determine the therapeutic and residual efficacy of a topically applied combination of cyphenothrin (40 %) and pyriproxyfen (2 %) against the tick Haemaphysalis elliptica and the flea Ctenocephalides felis on dogs. Twelve dogs were infested with 50 ticks 2 days before they were treated and with approximately 100 fleas 6 days before treatment and again 2 days before treatment and with 50 ticks and approximately 100 fleas at weekly intervals thereafter. They were ranked according to their flea counts and sex 5 days before treatment and randomly allocated to an untreated control group of 6 dogs and a treated group of 6 dogs. Ticks and fleas were collected from the dogs 48 h after treatment and 48 h after each infestation and live and dead ticks and live fleas were counted. The counts of ticks and fleas were transformed to geometric means, and efficacy was calculated by comparing these means. The product had a therapeutic efficacy of 83.1 % against H. elliptica and 97.5 % against C. felis 2 days after treatment. The residual period of protection during which efficacy was ≥ 90 % was 5 weeks for both H. elliptica and C. felis.

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