Noninvasive Assessment of Liver Fibrosis and Portal Hypertension With Transient Elastography

Portal hypertension represents a wide spectrum of complications of chronic liver diseases and may present by ascites, oesophageal varices, splenomegaly, hypersplenism, hepatorenal and hepatopulmonary syndrome or portopulmonary hypertension. Portal hypertension and its severity predicts the patient‘s prognosis: as an invasive technique, the portosystemic gradient (HPVG – hepatic venous pressure gradient) measurement by hepatic veins catheterisation has remained the gold standard of its assessment. A reliable, non-invasive method to assess the severity of portal hypertension is of paramount importance; the patients with clinically significant portal hypertension have a high risk of variceal bleeding and higher mortality. Recently, non-invasive methods enabling the assessment of liver stiffness have been introduced into clinical practice in hepatology. Not only may these methods substitute for liver biopsy, but they may also be used to assess the degree of liver fibrosis and predict the severity of portal hypertension. Nowadays, we can use the quantitative elastography (transient elastography, point shear-wave elastrography, 2D-shear-wave elastography) or magnetic resonance imaging. We may also assess the severity of portal hypertension based on the non-invasive markers of liver fibrosis (i.e. ELF test) or estimate clinically signifi cant portal hypertension using composite scores (LSPS – liver spleen stiff ness score), based on liver stiffness value, spleen diameter and platelet count. Spleen stiffness measurement is a new method that needs further prospective studies. The review describes current possibilities of the non-invasive assessment of portal hypertension and its severity.

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Transient Elastography: From Research to Noninvasive Assessment of Liver Fibrosis Using Fibroscan®

Ultrasound Elastography for Biomedical Applications and Medicine ◽

10.1002/9781119021520.ch20 ◽

2018 ◽

pp. 295-317

Author(s):

Laurent Sandrin ◽

Magali Sasso ◽

Stéphane Audière ◽

Cécile Bastard ◽

Céline Fournier ◽

...

Keyword(s):

Liver Fibrosis ◽

Transient Elastography ◽

Noninvasive Assessment

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Fibrospleen: Measuring spleen stiffness by transient elastography increases accuracy of staging of liver fibrosis and of portal hypertension in chronic viral hepatitis

Digestive and Liver Disease ◽

10.1016/j.dld.2008.12.078 ◽

2009 ◽

Vol 41 (3) ◽

pp. A38 ◽

Cited By ~ 1

Author(s):

V. Di Marco ◽

F. Bronte ◽

V. Calvaruso ◽

C. Cammà ◽

D. Cabibi ◽

...

Keyword(s):

Portal Hypertension ◽

Liver Fibrosis ◽

Viral Hepatitis ◽

Transient Elastography ◽

Chronic Viral Hepatitis ◽

Spleen Stiffness

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Emerging Trends and New Developments in Transient Elastography: A Bibliometric and Cocitation Analysis from 1999 to 2017

Canadian Journal of Gastroenterology and Hepatology ◽

10.1155/2019/3280657 ◽

2019 ◽

Vol 2019 ◽

pp. 1-7 ◽

Cited By ~ 2

Author(s):

Jingjing Gu ◽

Weimian Wang ◽

Ziyuan Zou ◽

Fangze Huang ◽

Chihua Fang ◽

...

Keyword(s):

Liver Fibrosis ◽

Transient Elastography ◽

Rapid Development ◽

Original Research ◽

Prolific Author ◽

New Developments ◽

Cocitation Analysis ◽

Emerging Trends ◽

Article Type ◽

Noninvasive Assessment

Purpose. To identify and characterize the 100 most-cited articles in the field of transient elastography.Methods. The top-cited articles focusing on transient elastography from 1999 to 2017 were retrieved from Science Citation Index Expanded (SCI-E) database. The most prolific article, journal, country and continent, top-cited article in different period, international collaboration, cocitation analysis of journal were retrieved and analyzed in this article. Bibexcel 2016, Microsoft Excel 2010, and VOSviewer 1.6.5 were used to analyze bibliometric records we downloaded.Results. The 100 most-cited articles were published between 2003 and 2015. The total citations ranged from 54 to 1376 (mean, 167.52 ± 208.46; median, 89.5) and the annual citations ranged from 4.91 to 98.24 (mean, 17.21±15.68; median, 12.1). The top-cited article was published inGastroenterologyin 2005 by Castera L. et al. (n=1376). The most-cited articles in 2003-2007 (n=1380), 2008-2012 (n=599) and 2013-2017 (n=159) were located. All of the most-cited articles in three periods were focusing on the topic of noninvasive assessment of liver fibrosis. The most prolific author was de Ledinghen V. (n=21) and France (n=43) was the leading country. The most productive journal wasJournal of Hepatology(n=20). The major article type was original research article.Conclusions. We undertook efforts to provide an insight into the features and evolvement of the most-cited articles in the field of transient elastography. For transient elastography, as a noninvasive assessment of liver fibrosis, its use in the evaluation of liver fibrosis is gradually mature and shows great advantages. Moreover, the field of transient elastography is in a stage of rapid development.

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