The treatment of irritable bowel syndrome is currently regulated based on the clinical guidelines for the management of the patients presenting with gastroenterological pathologies. Generally speaking, the pharmacotherapy is aimed at the main clinical symptoms of this condition (in the first place, constipation and diarrhea). Also important is the development of the therapeutic modalities designed for the correction of vegetative dysfunctions developing in the association with long-staying psychoemotional tension. At present, there are several factors exerting the corrective action on the vegetative system including magnetic therapy, electrically-induced sleep, and EHF-therapy. The present review of the literature does not exhaust all possibilities for the correction of the functional disorders associated with irritable bowel syndrome but emphasizes the necessity of the further investigation of this problem and the search for the new approaches to its solution.