American Gastroenterological Association Clinical Practice Update: Management of Pancreatic Necrosis

2020 ◽  
Vol 158 (1) ◽  
pp. 67-75.e1 ◽  
Author(s):  
Todd H. Baron ◽  
Christopher J. DiMaio ◽  
Andrew Y. Wang ◽  
Katherine A. Morgan
2020 ◽  
pp. 51-56
Author(s):  
Svetlana Styazhkina ◽  
Tatyana Chernyshova ◽  
Olga Neganova ◽  
Yuliya Russkikh ◽  
Raniya Gazimzyanova

Today, the problem of pancreonecrosis remains in the leading positions in urgent surgery. The incidence of this pathology increases every year. This article presents the results of the analysis of the use of the drug "Roncoleukin" in clinical practice for pancreonecrosis. The study was conducted to evaluate the effectiveness of this drug.


2020 ◽  
pp. 45-48
Author(s):  
V. I. Lupaltsov ◽  
N. N. Skalii ◽  
A. I. Yagnyuk ◽  
V. S. Kotovshchіkov

Summary. Purpose. To study the manometric control of pressure in the pancreatic ducts when performing ERCP and to determine its capabilities in the early diagnosis of postmanipulative pancreatitis. Materials and methods. The study was conducted to identify postmanipulative pancreatitis in 122 patients with impaired patency of the terminal part of the common bile duct who underwent ERCP. Patients were divided into two groups: the main – 58 patients and the comparison group – 64 patients. In 58 patients of the main group, the pressure in the pancreatic duct was studied by the device we developed. One makes it possible to register early signs of acute postmanipulative pancreatitis with conducting timely preventive measures for its development. Results. Using the proposed device that records the pressure in the pancreatic ducts, acute postmanipulative pancreatitis was diagnosed in 6.9 % of patients in the main group, while in the comparison group it developed in 21.9 % of cases. Mild forms of APMP in the comparison group were noted in 11 patients and in 4 patients in the main group. Severe APMP caused by focal pancreatic necrosis occurred in three cases of the comparison group. Conclusions. 1. ERCP is a highly effective method for diagnosing diseases of the pancreatobiliary zone, at the same time, sometimes fraught with the danger of developing serious complications, one of which is acute postmanipulative pancreatitis. 2. Monometric control during ERCP is a highly effective method for the diagnosis of early forms of acute postmanipulative pancreatitis, which can be recommended in the clinical practice of endoscopic surgeries.


Author(s):  
Baichorov E.Kh. ◽  
Baturin V.A. ◽  
Gandzha N.S. ◽  
Salpagarov Sh.R. ◽  
Bairamukov R.R.

The development of methods for predicting and pre-venting the development of infectious destructive forms of acute pancreatitis for clinical practice is one of the important problems of pancreatology, the solu-tion of which would reduce post-operative mortality in severe acute pancreatitis, reaching 30-80%. To date, traditional laboratory and instrumental methods of diagnosis do not fully satisfy clinicians, since they do not always allow timely and reliable determination of the probability and time of microbial contamina-tion of pancreatic and parapancreatic tissue in pa-tients with destructive pancreatitis. In this regard, it is of interest to search for new methods for predicting and timely diagnosis of infected forms of pancreatic necrosis, which would significantly improve the re-sults of treatment of severe forms of acute pancreatitis. The use of changes in the dynamics of levels of antimi-crobial peptides - α-defensins and Ubiquitin Protein Ligase E3 in the blood serum of patients for diagnos-tic purposes makes it possible to predict and deter-mine earlier the transformation of sterile pancreone-crosis into infected and can be used as markers of the development of contamination of destructive forms of acute pancreatitis.


2019 ◽  
Vol 14 (12) ◽  
pp. 764-765
Author(s):  
Ashley Jenkins ◽  
Jordan Shapiro

GUIDELINE TITLE: 2018 American Gastroenterological Association (AGA) Institute Guideline on Initial Management of Acute Pancreatitis RELEASE DATE: March 2018 PRIOR VERSION: Not applicable DEVELOPER: AGA Clinical Practice Guideline Committee FUNDING SOURCE: AGA Institute TARGET POPULATION: Patients within first 48-72 hours of admission with acute pancreatitis (AP)


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