scholarly journals Role of MAP kinases and their cross-talk in TGF-β1-induced apoptosis in FaO rat hepatoma cell line

Hepatology ◽  
2002 ◽  
Vol 35 (6) ◽  
pp. 1360-1371 ◽  
Author(s):  
Hyun-Jin Park ◽  
Byung-Chul Kim ◽  
Seong-Jin Kim ◽  
Kyeong Sook Choi
Keyword(s):  
Cell Line ◽  
Cross Talk ◽  
Map Kinases ◽  
Hepatoma Cell ◽  
Hepatoma Cell Line ◽  
Induced Apoptosis ◽  
Rat Hepatoma Cell Line ◽  
Tgf Β1 ◽  
Rat Hepatoma

Inhibition of cathepsin B by cystatin a reduces bile salt- but not staurosporine-induced apoptosis in a rat hepatoma cell line

1998 ◽  
Vol 114 ◽  
pp. A1266
Author(s):  
B.A. Jones ◽  
P.J. Roberts ◽  
S.F. Bronk ◽  
E. Kominami ◽  
L.B. Agellon ◽  
...  
Keyword(s):  
Bile Salt ◽  
Cell Line ◽  
Cathepsin B ◽  
Hepatoma Cell ◽  
Hepatoma Cell Line ◽  
Cystatin A ◽  
Induced Apoptosis ◽  
Rat Hepatoma Cell Line ◽  
Rat Hepatoma

Cystatin A expression reduces bile salt-induced apoptosis in a rat hepatoma cell line

1998 ◽  
Vol 275 (4) ◽  
pp. G723-G730 ◽  
Author(s):  
Blake Jones ◽  
Patricia J. Roberts ◽  
William A. Faubion ◽  
Eiki Kominami ◽  
Gregory J. Gores
Keyword(s):  
Bile Salt ◽  
Cell Line ◽  
Cathepsin B ◽  
Hepatoma Cell ◽  
Hydrolytic Activity ◽  
Hepatoma Cell Line ◽  
Cystatin A ◽  
Induced Apoptosis ◽  
Rat Hepatoma Cell Line ◽  
Rat Hepatoma

We have previously demonstrated abrogation of bile salt-induced apoptosis by cathepsin B inhibitors. However, caspases have been strongly implicated in apoptosis, and the mechanistic interface between caspase and cathepsin B activation is unclear. Thus our aims were to determine the mechanistic relationship between caspases and cathepsin B in bile salt-induced apoptosis in a rat hepatoma cell line. Expression of cystatin A was used to inhibit cathepsin B, whereas Z-Val-Ala-Asp-fluoromethyl ketone (Z-VAD-FMK) was used to inhibit caspases. Cystatin A expression prevented cathepsin B activation and apoptosis during treatment with glycochenodeoxycholate (GCDC), a toxic bile salt. Caspase N-acetyl-Asp-Glu-Val-Asp-7-amino-4-methylcoumarin (DEVD-AMC) hydrolytic activity increased in both wild-type and cystatin A-transfected cells treated with GCDC, demonstrating caspase activation despite inhibition of cathepsin B. In contrast, Z-VAD-FMK blocked both DEVD-AMC hydrolytic activity and cathepsin B activity during GCDC treatment. Our data demonstrate that 1) bile salt-induced apoptosis can be inhibited by the cystatin A transgene and 2) caspase and cathepsin B activation are linked mechanistically with cathepsin B downstream of caspases.

Specific modulation by ethanol of the protein synthesis pattern in the C2 rat hepatoma cell line

1988 ◽  
Vol 6 (1) ◽  
pp. 85-93 ◽  
Author(s):  
M.N. Chobert ◽  
P. Vincens ◽  
G. Guellaën ◽  
R. Barouki ◽  
Y. Laperche ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Cell Line ◽  
Hepatoma Cell ◽  
Hepatoma Cell Line ◽  
Rat Hepatoma Cell Line ◽  
Rat Hepatoma

scholarly journals Identification of a somatomedin-binding protein produced by a rat hepatoma cell line

FEBS Letters ◽  
1981 ◽  
Vol 127 (2) ◽  
pp. 225-227 ◽  
Author(s):  
Dan H. Morris ◽  
Don S. Schalch ◽  
Barbara Monty-Miles
Keyword(s):  
Cell Line ◽  
Binding Protein ◽  
Hepatoma Cell ◽  
Hepatoma Cell Line ◽  
Rat Hepatoma Cell Line ◽  
Rat Hepatoma
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