scholarly journals Epstein-Barr virus detection using gastric biopsy specimens after rapid urease test for Helicobacter pylori

2019 ◽  
Vol 07 (04) ◽  
pp. E431-E432 ◽  
Author(s):  
Hideo Yanai ◽  
Hisashi Iizasa ◽  
Daisuke Chihara ◽  
Tomoyuki Murakami ◽  
Jun Nishikawa ◽  
...  
2020 ◽  
Vol 8 (6) ◽  
pp. 923
Author(s):  
Andy Visi Kartika ◽  
Hisashi Iizasa ◽  
Dan Ding ◽  
Yuichi Kanehiro ◽  
Yoshitsugu Tajima ◽  
...  

Persistent gastric mucosal damage caused by Helicobacter pylori infection is a major risk factor for gastric cancer (GC). The Epstein–Barr virus (EBV) is also associated with GC. Most patients with EBV-associated GC are infected with H. pylori in East Asia. However, very few reports have described where and when both H. pylori and EBV infect the gastric mucosa. To clarify this, old biopsy samples used for the rapid urease test (RUT) were applied to count EBV genomic DNA (gDNA) copies using DNA probe quantitative polymerase chain reaction. DNA extracted from the gastric biopsy samples of 58 patients with atrophic gastritis was used to analyze the correlation between the degree of atrophic gastritis and the copy number of EBV gDNA. EBV was detected in 44 cases (75.9%), with viral copy numbers ranging from 12.6 to 4754.6. A significant correlation was found between patients with more than 900 copies of EBV gDNA and those with a more severe grade of atrophic gastritis (p = 0.041). This study shows that EBV can be detected in RUT samples in a manner that reduces patient burden.


1995 ◽  
Vol 41 (4) ◽  
pp. 336
Author(s):  
JF Fitzgerald ◽  
SKF Chong ◽  
JM Croffie ◽  
JD Rogge ◽  
DR Wagner ◽  
...  

1993 ◽  
Vol 9 (4) ◽  
pp. 450-452 ◽  
Author(s):  
S. Kamiya ◽  
I. Taniguchi ◽  
T. Yamamoto ◽  
T. Shirai ◽  
S. Harasawa ◽  
...  

Gene Reports ◽  
2021 ◽  
Vol 23 ◽  
pp. 101165
Author(s):  
Raed Obaid Saleh ◽  
Najwa Shihab Ahmed ◽  
Emad A. Ewais ◽  
Aqeel Shakir Mahmood ◽  
Ahmed R. Sofy

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