NSAIDs-induced upper gastrointestinal bleeding in hepatitis B virus-positive patient with acute kidney injury – nonocclusive mesenteric ischemia

ABSTRACT BACKGROUND: The Amazon region is one of the main endemic areas of hepatitis delta in the world and the only one related to the presence of genotype 3 of the delta virus. OBJECTIVE: To analyze the profile, mortality and survival of cirrhotic patients submitted to liver transplantation for chronic hepatitis delta virus and compare with those transplanted by hepatitis B virus monoinfection. METHODS: Retrospective, observational and descriptive study. From May 2002 to December 2011, 629 liver transplants were performed at the Walter Cantídio University Hospital, of which 29 patients were transplanted due to cirrhosis caused by chronic delta virus infection and 40 by hepatitis B chronic monoinfection. The variables analyzed were: age, sex, MELD score, Child-Pugh score, upper gastrointestinal bleeding and hepatocellular carcinoma occurrence before the transplantation, perioperative platelet count, mortality and survival. RESULTS: The Delta Group was younger and all came from the Brazilian Amazon Region. Group B presented a higher proportion of male patients (92.5%) compared to Group D (58.6%). The occurrence of upper gastrointestinal bleeding before transplantation, MELD score, and Child-Pugh score did not show statistical differences between groups. The occurrence of hepatocellular carcinoma and mortality were higher in the hepatitis B Group. The survival in 4 years was 95% in the Delta Group and 75% in the B Group, with a statistically significant difference (P=0.034). Patients with hepatitis delta presented more evident thrombocytopenia in the pre-transplantation and in the immediate postoperative period. CONCLUSION: The hepatitis by delta virus patients who underwent liver transplantation were predominantly male, coming from the Brazilian Amazon region and with similar liver function to the hepatitis B virus patients. They had a lower incidence of hepatocellular carcinoma, more marked perioperative thrombocytopenia levels and frequent episodes of upper gastrointestinal bleeding. Patients with hepatitis by delta virus had lower mortality and higher survival than patients with hepatitis B virus.

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Acute kidney injury in a patient treated with tenofovir alafenamide fumarate for Hepatitis B virus infection

Saudi Journal of Kidney Diseases and Transplantation ◽

10.4103/1319-2442.335480 ◽

2021 ◽

Vol 32 (2) ◽

pp. 592

Author(s):

V Jayaprakash ◽

A Deiva ◽

Nisha Jose ◽

KN Chandan Kumar ◽

M Jayakumar

Keyword(s):

Acute Kidney Injury ◽

Hepatitis B Virus ◽

Virus Infection ◽

Hepatitis B ◽

Kidney Injury ◽

Hepatitis B Virus Infection ◽

B Virus ◽

Tenofovir Alafenamide

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Acute kidney injury in patients with hepatitis B virus related acute-on-chronic liver failure is different from in decompensated cirrhosis

Journal of Hepatology ◽

10.1016/s0168-8278(18)30702-5 ◽

2018 ◽

Vol 68 ◽

pp. S243

Author(s):

Q. Jiang ◽

M. Han ◽

K. Ma ◽

G. Chen ◽

W. Wu ◽

...

Keyword(s):

Acute Kidney Injury ◽

Hepatitis B Virus ◽

Hepatitis B ◽

Liver Failure ◽

Kidney Injury ◽

Chronic Liver ◽

Decompensated Cirrhosis ◽

Chronic Liver Failure ◽

B Virus

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Mo1389 ACUTE KIDNEY INJURY IS AN INDEPENDENT PREDICTOR OF IN-HOSPITAL MORTALITY AND POOR OUTCOMES AMONG PATIENTS WITH UPPER GASTROINTESTINAL BLEEDING: A NATIONWIDE ANALYSIS

Gastroenterology ◽

10.1016/s0016-5085(20)32866-3 ◽

2020 ◽

Vol 158 (6) ◽

pp. S-872

Author(s):

Ahmad Khan ◽

Nasir Saleem ◽

srikanth r. maddika ◽

Mohammad Bilal ◽

Shailendra Singh

Keyword(s):

Acute Kidney Injury ◽

Gastrointestinal Bleeding ◽

Hospital Mortality ◽

Upper Gastrointestinal Bleeding ◽

Independent Predictor ◽

Kidney Injury ◽

Poor Outcomes ◽

Upper Gastrointestinal

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The Risk of Acute Kidney Injury in Hepatitis B Virus-Related Acute on Chronic Liver Failure with Tenofovir Treatment

BioMed Research International ◽

10.1155/2020/5728359 ◽

2020 ◽

Vol 2020 ◽

pp. 1-8

Author(s):

Kai Zhang ◽

Su Lin ◽

Mingfang Wang ◽

Jiaofeng Huang ◽

Yueyong Zhu

Keyword(s):

Acute Kidney Injury ◽

Hepatitis B Virus ◽

Hepatitis B ◽

Liver Failure ◽

Antiviral Drug ◽

Kidney Injury ◽

Chronic Liver ◽

Chronic Liver Failure ◽

Significant Difference ◽

B Virus

Aims. Tenofovir (TDF) is an antiviral drug with potential risk of kidney injury. The study is aimed at comparing the incidence of acute kidney injury (AKI) between TDF and entecavir (ETV) treatment in hepatitis B virus- (HBV-) related acute on chronic liver failure (ACLF). Methods. Treatment-naive patients with HBV-related ACLF were included. Propensity score matching was used to balance the baseline characteristics between ETV and TDF groups. The risk of AKI and the efficacy of TDF and ETV were compared. Results. A total of 95 cases with HBV-related ACLF were included in this study, with 74.74% of male and a mean age of 47.01±14.71 years. The antiviral therapy was initiated within 2 days after admission, with 39 cases on the TDF group and 56 on the ETV group. Patients in the TDF group had higher AST, hemoglobin, and serum sodium levels and lower MELD-Na score. After propensity matching, 39 cases of TDF and 39 of ETV were included in the final analysis. No difference was found in the changes of creatinine and cystatin C from baseline to 4 weeks after treatment between ETV and TDF groups. AKI was developed in 1 (2.56%) patient in the ETV group and 2 (5.13%) in the TDF group within one month (P=0.556). Survival analysis revealed no significant difference in the 6-month mortality between the two groups (P=0.813). Cox analysis showed that the type of antiviral drug or the development of AKI was not an independent risk factor for the outcomes. Conclusions. Compared to ETV, TDF did not increase the risk of AKI nor the mortality in patients with HBV-related ACLF in the short time.

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