Postinfectious T-lymphocytic enteral leiomyositis as a rare cause of chronic intestinal pseudoobstruction

2021 ◽  
Vol 59 (04) ◽  
pp. 326-330
Author(s):  
Bismark Osei Sarfo ◽  
Hakan Kopdag ◽  
Marian-Christopher Pott ◽  
Lars Stiedenroth ◽  
Ulf Nahrstedt ◽  
...  
Keyword(s):  
Immunosuppressive Therapy ◽  
Adult Female ◽  
Stable Disease ◽  
Paralytic Ileus ◽  
Intestinal Wall ◽  
Tnf Alpha ◽  
Full Thickness ◽  
Slow Recovery ◽  
Intestinal Pseudoobstruction ◽  
Intestinal Pseudo Obstruction

AbstractT-lymphocytic enteral leiomyositis (T-lel) is a rare disorder causing chronic intestinal pseudo-obstruction (CIPO), with cases predominantly being reported in the field of veterinary and pediatric medicine. Here, we present a case of T-lel-associated CIPO in an adult female, who initially presented with a paralytic ileus 2 weeks after a common gastroenteritis. The histological diagnosis was established through full-thickness bowel biopsy, exhibiting a dense lymphocytic infiltrate in the lamina muscularis of the intestinal wall. This case shows that T-lel can be a cause of chronic intestinal pseudo-obstruction not only in children but also in adults. A subsequent induction of an immunosuppressive therapy with steroids, azathioprine, and ultimately TNF-alpha-inhibiting antibodies led to a slow recovery and stable disease.

scholarly journals Chronic intestinal pseudo-obstruction in a dog: case report

2011 ◽  
Vol 63 (6) ◽  
pp. 1323-1329 ◽  
Author(s):  
A.L. Bicalho ◽  
A.P.C. Silva ◽  
T.A. Paixão ◽  
R.B. Cardoso Jr. ◽  
R.L. Santos
Keyword(s):  
Small Intestine ◽  
Intestinal Wall ◽  
Full Thickness ◽  
Muscularis Mucosae ◽  
Muscular Layer ◽  
Distended Abdomen ◽  
Pathological Conditions ◽  
Biopsy Specimens ◽  
History Of ◽  
Intestinal Pseudo Obstruction

Intestinal pseudo-obstruction is a rare disorder that affects gastrointestinal propulsion. It may be secondary to several pathological conditions or it may develop without a known cause. A 1.2 year-old intact Pug bitch had a history of vomiting and constipation, which were followed by diarrhea and distended abdomen. Hypomotility and dilation of the small intestine, which was filled with gas, were observed during laparotomy. Histologically, full thickness biopsy specimens demonstrated a severe loss and degeneration of leiomyocytes in the inner and outer muscular layers of the intestinal wall, whereas there was a marked hypertrophy and hyperplasia of smooth muscle cells in the lamina propria, and extremely thickened muscularis mucosae arranged in bundles oriented in different directions with marked hypertrophy and hyperplasia of leiomyocytes. Distribution of leiomyocytes was further characterized by immunohistochemistry. These findings support the diagnosis of intestinal pseudo-obstruction in a Pug, associated with degeneration and loss of leiomyocytes in the muscular layer.

Fine structure and cytochemical analysis of the intestinal wall along the body of adult female of Litomosoides chagasfilhoi (Nematoda: Filarioidea)

2006 ◽  
Vol 98 (6) ◽  
pp. 525-533 ◽  
Author(s):  
A. H. A. de Moraes Neto ◽  
G. S. P. Cunha ◽  
T. F. Ferreira ◽  
S. N. de Carvalho ◽  
E. V. Guimarães ◽  
...  
Keyword(s):  
Fine Structure ◽  
Adult Female ◽  
Intestinal Wall ◽  
The Body ◽  
Cytochemical Analysis

scholarly journals Postoperative Chronic Paralytic Ileus Resembling Chronic Idiopathic Intestinal Pseudo-Obstruction: A Case Report

2014 ◽  
Vol 39 (5) ◽  
pp. 926-933
Author(s):  
Takatsugu Yamamoto ◽  
Yukiko Kurashima ◽  
Kazunori Ohata ◽  
Masato Okawa ◽  
Shogo Tanaka ◽  
...  
Keyword(s):  
Case Report ◽  
Paralytic Ileus ◽  
Intestinal Pseudo Obstruction

Outcomes of treatment of juvenile idiopathic arthritis related uveitis with TNF-alpha inhibitors

2014 ◽  
Vol 5 (4) ◽  
pp. 60-64
Author(s):  
Ekaterina Vladimirovna Gaidar ◽  
Mikhail Mikhaylovich Kostik ◽  
Ludmila Stepanovna Snegireva ◽  
Margarita Fedorovna Dubko ◽  
Vera Vasilyevna Masalova ◽  
...  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Immunosuppressive Therapy ◽  
Immunosuppressive Agents ◽  
Tnf Alpha ◽  
Early Administration ◽  
Systemic Corticosteroids ◽  
Alpha Receptors ◽  
Membrane Bound

The aim of the study was to evaluate the efficacy of two anti-TNF-alpha biological agents: Adalimumab (humanized monoclonal anti-TNF-alpha antibody) and Infliximab (chimeric monoclonal antibody that binds both circulating and membrane-bound TNF-alpha receptors) in treatment of Juvenile Idiopathic Arthritis related uveitis. 37 children (73 % girls) with uveitis associated with aggressive forms of JIA who failed Methotrexate and topical treatment; Methotrexate and other immunosuppressive agents and systemic corticosteroids were included in the study. The age of patients at the beginning of biological therapies ranged 5-17 years. In ADA group the remission was observed in 61 % of cases, in 18 % we saw the reduction of flare-ups and in 14 % of children we registered exacerbation of the disease which was caused in most cases by discontinuation of non-biological drug. In INF group we observed remission in 78 % of the cases, no improvement in 22 %. The speed of remission in JIA associated uveitis treated with ADA and INF depended on the severity of uveitis, the time between the beginning of the disease and administration of immunosuppressive therapy. Early administration of anti-TNF-alpha agents, when there is no results from standard immunosuppressive therapy, allowed us to achieve remission in a shorter period of time and also allowed as to decrease the severity of complications of uveitis, as well as reduce the side effects of immunosuppressive therapy, especially of corticosteroids. This study needs to be continued to enroll more patients and to increase the follow-up time to evaluate the long-term efficacy and safety of anti-TNF-alpha agents in JIA associated uveitis.

Full-thickness biopsy findings in chronic intestinal pseudo-obstruction and enteric dysmotility

Gut ◽  
2009 ◽  
Vol 58 (8) ◽  
pp. 1084-1090 ◽  
Author(s):  
G. Lindberg ◽  
H. Tornblom ◽  
M. Iwarzon ◽  
B. Nyberg ◽  
J. E. Martin ◽  
...  
Keyword(s):  
Full Thickness ◽  
Intestinal Pseudo Obstruction

Fatal Strongyloidiasis in Gibbons (Hylobates lar)

1978 ◽  
Vol 15 (1) ◽  
pp. 31-39 ◽  
Author(s):  
A. DePaoli ◽  
D. O. Johnsen
Keyword(s):  
Weight Loss ◽  
Retrospective Study ◽  
Gastrointestinal Tract ◽  
Cause Of Death ◽  
Adult Female ◽  
Paralytic Ileus ◽  
Clinical Signs ◽  
Wide Distribution ◽  
Hylobates Lar

A 6-year retrospective study of necropsy material from a colony of 200 gibbons showed strongyloidiasis to be the most frequent cause of death (24 cases). Clinical signs included diarrhea, constipation, weight loss, paralytic ileus and dyspnea. Lesions were most frequent in the gastrointestinal tract and lungs. In the gut there were erosive and ulcerative enteritis associated with adult female parasites and rhabditiform larvae and acute and granulomatous enterocolitis associated with invading filariform larvae. There was severe multifocal or diffuse hemorrhage associated with migrating larvae in the lungs of 23 gibbons. Filariform larvae and the lesions they caused also occurred in various tissues; this was commensurate with the wide distribution of these larvae when hyperinfection occurred.

The value of full-thickness bowel biopsy in the management of acute intestinal pseudo-obstruction

2005 ◽  
Vol 9 (1) ◽  
pp. 31-33
Author(s):  
Krishnan Gokul ◽  
Julie Iddon ◽  
M. Anita Brown ◽  
Fiona Campbell ◽  
Dmitri Y. Artioukh
Keyword(s):  
Full Thickness ◽  
Intestinal Pseudo Obstruction

scholarly journals The activity of selected hydrolases of adult female Ascaris suum, Goeze 1782

2006 ◽  
Vol 43 (2) ◽  
pp. 59-63 ◽  
Author(s):  
J. Dziekońska-Rynko
Keyword(s):  
High Activity ◽  
Adult Female ◽  
Ascaris Suum ◽  
Intestinal Wall

AbstractThe activity of hydrolases was measured in the perienteric fluid, muscles and three sections of the intestine of female Ascaris suum. In none of the examined samples was the activity of lipase and α-galactosidase detected. The activity of hydrolases in anterior, middle and posterior sections of the A. suum intestine was similar. The high activity of the following glucosidases: β-galactosidase (lactase), N-acetyl-β glucosaminidase and α-fucosidase, was detected in the contents and extracts from the intestinal wall, apart from the activity of those found in earlier studies. In perienteric fluid and in extracts from muscles, a high activity of β-glucuronidase and β-glucosidase was detected; such activity was not found in the intestine.

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