Steroid-refractory ulcerative colitis: a critical review of national and international guideline recommendations

2021 ◽  
Author(s):  
Eduard F. Stange
Keyword(s):  
Ulcerative Colitis ◽  
Colitis Ulcerosa ◽  
Critical Review ◽  
International Guideline ◽  
Steroid Refractory

ZusammenfassungEs gibt zahlreiche nationale und internationale Leitlinien zu chronisch entzündlichen Darmerkrankungen, die auf vergleichbarer Evidenz sowie ähnlichen Prozeduren beruhen und daher homogen sein sollten. In dieser kritischen Übersicht wurden die Leitlinienempfehlungen aus Europa (ECCO), Deutschland, Großbritannien, Kanada, den USA und Japan zur Therapie der steroidrefraktären Colitis ulcerosa verglichen. Die meisten Leitlinien unterschieden zwischen moderater/schwerer (ambulanter) und schwerer/fulminanter Colitis in der Klinik. Die Empfehlungen zur ersten Kategorie weisen gravierende Unterschiede auf, während zur Behandlung des stationären Patienten weitgehende Übereinstimmung herrscht. Verschiedene Erklärungen für die Inkonsistenzen werden diskutiert.

Outcome of tacrolimus treatment in steroid-refractory or -dependent ulcerative colitis - experience in 220 patients

2013 ◽  
Vol 51 (08) ◽  
Author(s):  
KJ Schmidt ◽  
N Müller ◽  
J Emmrich ◽  
A Dignaß ◽  
H Lehnert ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Steroid Refractory

Anti-TNF-α therapy in ulcerative colitis

2008 ◽  
Vol 149 (20) ◽  
pp. 921-927
Author(s):  
Péter László Lakatos ◽  
László Lakatos
Keyword(s):  
Ulcerative Colitis ◽  
Colitis Ulcerosa ◽  
Tnf Α

A colitis ulcerosa kezelését meghatározó legfontosabb tényezők a betegség kiterjedése és súlyossága. Az enyhe és középsúlyos betegek nagy többsége ma is a hagyományos gyógyszereket kapja (orális-topicalis 5-ASA, sulfasalazin). A hagyományos terápiára (szteroid, azathioprin, 5-ASA) rezisztens és a súlyos, akut colitis ulcerosa kezelése ugyanakkor nincs megoldva. Az újabb adatok alapján az infliximab indukciós vagy fenntartó kezelés formájában mindkét betegcsoportban hatékony kezelési alternatívát jelenthet, így az esetek egy részében elkerülhetővé válik a colectomia. Az összefoglalóban a szerzők colitis ulcerosában az anti-TNF-α-kezeléssel kapcsolatos eredményeket foglalták össze.

Mo1889 CORRELATION OF EARLY INFLIXIMAB LEVELS WITH SHORT TERM OUTCOMES IN STEROID REFRACTORY ULCERATIVE COLITIS: A PILOT STUDY

2020 ◽  
Vol 158 (6) ◽  
pp. S-964-S-965
Author(s):  
Srishti Saha ◽  
Prabhjot Grace Dosanjh ◽  
Edward V. Loftus ◽  
Sahil Khanna ◽  
Darrell S. Pardi
Keyword(s):  
Ulcerative Colitis ◽  
Pilot Study ◽  
Short Term ◽  
Steroid Refractory

scholarly journals Long-term Outcomes in Steroid-refractory Ulcerative Colitis Treated with Tacrolimus Alone or in Combination with Purine Analogues

2015 ◽  
Vol 10 (1) ◽  
pp. 31-37 ◽  
Author(s):  
K. J. Schmidt ◽  
N. Müller ◽  
A. Dignass ◽  
D. C. Baumgart ◽  
H. Lehnert ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Long Term Outcomes ◽  
Purine Analogues ◽  
Steroid Refractory

Early colectomy in steroid-refractory acute severe ulcerative colitis improves operative outcome

2017 ◽  
Vol 33 (1) ◽  
pp. 79-82 ◽  
Author(s):  
Sujeet Kumar Saha ◽  
Rajesh Panwar ◽  
Ameet Kumar ◽  
Sujoy Pal ◽  
Vineet Ahuja ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Severe Ulcerative Colitis ◽  
Operative Outcome ◽  
Steroid Refractory

scholarly journals A Comparison of Short- and Long-Term Therapeutic Outcomes of Infliximab- versus Tacrolimus-Based Strategies for Steroid-Refractory Ulcerative Colitis

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Katsuya Endo ◽  
Motoyuki Onodera ◽  
Hisashi Shiga ◽  
Masatake Kuroha ◽  
Tomoya Kimura ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Therapeutic Efficacy ◽  
Maintenance Treatment ◽  
Remission Rate ◽  
Rank Test ◽  
Clinical Response Rate ◽  
Therapeutic Outcomes ◽  
Significant Difference ◽  
Steroid Refractory

Background/Aims. Antitumor necrosis factor antibodies and calcineurin inhibitors have shown good therapeutic efficacy for steroid-refractory ulcerative colitis (UC). Although some studies have compared the efficacy of infliximab (IFX) and cyclosporin A, there are no published studies comparing IFX and tacrolimus (Tac). This study aimed to compare therapeutic efficacies between IFX- and Tac-based strategies for steroid-refractory UC.Methods. Between July 2009 and August 2013, 95 patients with steroid-refractory UC received either IFX(n=48)or Tac(n=47)in our hospital. In the IFX group, the patients continued to receive maintenance treatment with IFX. In the Tac group, patients discontinued Tac treatment up to 3 months and subsequently received thiopurine. We retrospectively compared the therapeutic outcomes between the groups.Results. There was no significant difference in the colectomy-free rate, clinical remission rate, and clinical response rate at 2 months between the groups. However, relapse-free survival was significantly higher in the IFX group than in the Tac group (p<0.001; log-rank test). The proportions of serious adverse events did not differ between the groups.Conclusion.The findings of our study showed that IFX and Tac have similar short-term therapeutic efficacy for steroid-refractory UC. Maintenance treatment with IFX, however, yields better long-term outcomes than Tac-thiopurine bridging treatment.

scholarly journals P337 The switching therapy between infliximab and tacrolimus in steroid-refractory ulcerative colitis

2013 ◽  
Vol 7 ◽  
pp. S144-S145 ◽  
Author(s):  
K. Kimura ◽  
K. Matsuoka ◽  
J. Miyoshi ◽  
S. Mizuno ◽  
N. Inoue ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Switching Therapy ◽  
Steroid Refractory

Early colectomy in steroid-refractory acute severe ulcerative colitis improves operative outcome

2015 ◽  
Vol 12 ◽  
pp. S25
Author(s):  
Sujeet Kumar Saha ◽  
Ameet Kumar ◽  
Rajesh Panwar ◽  
Sujoy Pal ◽  
Nihar Ranjan Dash ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Severe Ulcerative Colitis ◽  
Operative Outcome ◽  
Steroid Refractory
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