Comparison of the Effect of Preoperative Anxiety on the Oxidative Stress Biomarkers in Umbilical Cord Blood After Vaginal and Cesarean Delivery

2021 ◽  
Author(s):  
Ökkeş Hakan Miniksar ◽  
Demet Aydogan Kırmızı ◽  
Melike Demir Çaltekin ◽  
Mahmut Kılıç ◽  
Dilsad Yildiz Miniksar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Preoperative Anxiety ◽  
Oxidative Stress Biomarkers ◽  
Factors Affecting ◽  
Stress Biomarkers ◽  
Anxiety Levels ◽  
Delivery Type

Abstract Objective This study examined the independent effect of delivery type and preoperative anxiety on placenta oxidative stress response. Materials and methods A total of 126 patients who gave birth were divided into two groups according to delivery type: vaginal delivery group (VD) (n=56) and elective cesarean section delivery group (CS) (n=70). The preoperative anxiety levels of pregnant women who came to the delivery room were evaluated with the State Anxiety Inventory (SAI) scale. Malonyldialdehyde (MDA), superoxide dismutase (SOD), total antioxidative status (TAS), total oxidative state (TOS), and oxidative stress index (OSI) levels in umbilical cord blood were compared according to preoperative anxiety level and type of delivery. Results The CS group had significantly higher MDA (0.88±0.15 versus 0.79±0.09, p=0.001) and TOS (8.37±1.81 versus 7.53±0.77, p=0.019) values compared to the VD group. TAS levels did not differ significantly between the groups. SOD levels were higher in VD group compared to CS group (p=0.049). When the factors affecting oxidative stress biomarkers are analyzed by regression analysis, factors affecting MDA were found to be SAI score (Beta=0.358), CS (Beta=0.212), the factor affecting SOD was found to be VD (Beta=0.318), the factors affecting TOS were found to be SAI score (Beta=0.317) and CS (Beta=0.183). Conclusıon Oxidative stress biomarker levels in umbilical cord blood and preoperative anxiety levels were higher in patients who underwent elective caesarean section than those who delivered vaginally. Preoperative anxiety was the factor that increased oxidative stress biomarkers of umbilical cord blood the most.

scholarly journals Oxidative Stress in Preterm Neonates: An Analysis of Oxidative Stress Biomarkers and Antioxidant Profiles

2020 ◽  
Author(s):  
Shobha S Pajai ◽  
Apurva P Bezalwar
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Vitamin C ◽  
Cord Blood ◽  
Defense Mechanism ◽  
Preterm Neonates ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers ◽  
Study Results ◽  
Preterm Babies

Introduction: Oxidative stress is a complex event determined genetically and induced by an in- utero stressor. Oxidants are composed of reactive free radicals like Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS) which are manifested by several macromolecules of lipid, protein and DNA, causing deleterious effects in several organs. Antioxidant defense mechanism and its ability to be induced by hyperoxia is relatively impaired in preterm neonates. Aim: To study oxidative stress and antioxidants in preterm neonates. Materials and Methods: This study is an observational analytical study, which included preterm babies (25 males and 20 females) delivered vaginally from October 2012 to October 2013. Cord blood was collected in citrate bulbs immediately after vaginal delivery and stored at 4°C until processed. Malondialdehyde (MDA), Nitrates, Vitamin C and Vitamin E, levels were measured in cord blood. Statistical z-test was applied. Results: High levels of oxidative stress biomarkers like MDA and Nitrites along with decreased levels of antioxidants, Vitamin C and Vitamin E in preterm neonates was observed. MDA and Nitrates levels were significantly higher in males (p<0.05) than females. Vitamin C and Vitamin E levels were not significant (p>0.05) in both. Conclusion: This study results may conclude that preterm neonates have more oxidative stress especially in males affecting their life survival.

Umbilical cord blood markers of oxidative stress in pregnancies complicated by preterm prelabor rupture of membranes

2015 ◽  
Vol 29 (12) ◽  
pp. 1900-1910 ◽  
Author(s):  
Ivana Musilova ◽  
Lubomira Tothova ◽  
Ramkumar Menon ◽  
Barbora Vlkova ◽  
Peter Celec ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Markers Of Oxidative Stress ◽  
Prelabor Rupture Of Membranes

Correlation between circulating biomarkers of oxidative stress of maternal and umbilical cord blood at birth

2006 ◽  
Vol 40 (6) ◽  
pp. 565-570 ◽  
Author(s):  
Sandro Argüelles ◽  
Maria José Machado ◽  
Antonio Ayala ◽  
Alberto Machado ◽  
Blas Hervías
Keyword(s):  
Oxidative Stress ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Circulating Biomarkers ◽  
Biomarkers Of Oxidative Stress

Factors affecting umbilical cord blood stem cell suitability for transplantation in an in utero collection program

Transfusion ◽  
2013 ◽  
Vol 54 (3) ◽  
pp. 545-549 ◽  
Author(s):  
Christine L. Keersmaekers ◽  
Brian A. Mason ◽  
Jan Keersmaekers ◽  
Matthew Ponzini ◽  
Ryan A. Mlynarek
Keyword(s):  
Stem Cell ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
In Utero ◽  
Blood Stem Cell ◽  
Factors Affecting ◽  
Cord Blood Stem Cell ◽  
Collection Program

Maternal Epilepsy and Umbilical Cord Blood Oxidative Stress Level

2021 ◽  
pp. 1-10
Author(s):  
Kadriye Yakut ◽  
Fatma Doğa Öcal ◽  
Cem Sanhal ◽  
Özgür Öcal ◽  
Yüksel Oğuz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Stress Level ◽  
Umbilical Cord Blood ◽  
Oxidative Stress Level

scholarly journals Prooxidant-Antioxidant Balance in Umbilical Cord Blood of Infants with Meconium Stained of Amniotic Fluid

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Mohammad Hassan Arjmand ◽  
Farhat Ahmad Shah ◽  
Masoud Saleh Moghadam ◽  
Fatemeh Tara ◽  
Amin Jalili ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Amniotic Fluid ◽  
Cord Blood ◽  
Neonatal Mortality ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Meconium Aspiration Syndrome ◽  
Meconium Aspiration ◽  
Mortality And Morbidity ◽  
Healthy Infants

Objective. Using a novel assay termed prooxidant-antioxidant balance (PAB) assay to determine prooxidant-antioxidant balance in umbilical cord blood of infants with meconium stained of amniotic fluid (MSAF). Passage of meconium in amniotic fluid is associated with increase of neonatal mortality and morbidity. This complication occurs in about 15% of infants and is more widespread in postterm neonates. About 1.5 percent of neonates with MSAF develop meconium aspiration syndrome.Method. Sera of 29 umbilical cord blood of infants with MSAF and 32 healthy infants (HI) were collected. Both groups had nonsmoker and non-alcoholic mothers with no diseases. The PAB was measured.Result. There was a significant increase of PAB value (32.8±15.9 HK) in umbilical cord blood of infants with MSAF in comparison to HI (24.5±12.6 HK) (P<0.05). There was no significant correlation between PAB value and age of mothers.Conclusion. The increased PAB value in infants with MSAF showed that these infants are exposed to oxidative stress. Further research with larger population is needed to demonstrate the oxidative stress in infants with MSAF.

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