Asymmetric Rhodium-Catalyzed Allylic Substitution Reactions with Nitrile-Stabilized Carbanions
Keyword(s):
This Account summarizes our recent work on rhodium-catalyzed allylic alkylation reactions with nitrile-stabilized carbanions. Despite the challenges associated with employing nitrile stabilized nucleophiles in transition-metal-catalyzed reactions, we recently developed both enantiospecific and enantioselective allylic alkylation reactions. Notably, these novel reactions permit the expedient and selective access to an array of acyclic ternary and quaternary stereogenic centers that are present in important biologically active molecules. 1 Introduction 2 Enantiospecific Reactions of Nitrile-Stabilized Anions 3 Enantioselective Reactions of Nitrile-Stabilized Anions 4 Conclusion
2002 ◽
Vol 74
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pp. 1327-1337
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2012 ◽
Vol 51
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pp. 1922-1925
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2019 ◽
Vol 16
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pp. 460-484
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2015 ◽
Vol 21
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pp. 4209-4212
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