Ligustilide Suppresses the Biological Properties of Danggui Buxue Tang: A Chinese Herbal Decoction Composed of Radix Astragali and Radix Angelica sinensis

Planta Medica ◽  
2009 ◽  
Vol 76 (05) ◽  
pp. 439-443 ◽  
Author(s):  
Yu Zheng ◽  
Roy Choi ◽  
Jun Li ◽  
Heidi Xie ◽  
Anna Cheung ◽  
...  
2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Wendy L. Zhang ◽  
Ken Y. Z. Zheng ◽  
Kevin Y. Zhu ◽  
Janis Y. X. Zhan ◽  
Cathy W. C. Bi ◽  
...  

Roots ofAngelica sinensis(Danggui) have been used in promoting blood circulation as herbal medicine for over 2000 years in China. Another species ofAngelicaroots calledA. gigasis being used in Korea. To reveal the efficiency of differentAngelicaroots, the chemical and biological properties ofAngelicaroots from different cultivated regions were compared. Roots ofA. sinensiscontained higher levels of ferulic acid, Z-ligustilide, and senkyunolide A, while high amounts of butylphthalide and Z-butylenephthalide were found inA. gigasroots. The extracts deriving fromA. gigasroots showed better effects in osteogenic and estrogenic properties than that ofA. sinensisfrom China. However, this difference was markedly reduced when theAngelicaroots were being prepared in a Chinese herbal decoction together with Astragali Radix as Danggui Buxue Tang. In contrast, the herbal decoction prepared fromA. sinensisroots showed better responses in cell cultures. In addition, the extracts ofA. gigasroots showed strong cell toxicity both as single herb and as Danggui Buxue Tang. This result revealed the distinct properties ofAngelicaroots from China and Korea suggesting the specific usage of herb in preparing a unique herbal decoction.


Planta Medica ◽  
2009 ◽  
Vol 75 (06) ◽  
pp. 602-606 ◽  
Author(s):  
Winnie Li ◽  
Jun Li ◽  
Cathy Bi ◽  
Anna Cheung ◽  
Wen Huang ◽  
...  

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