Maintenance of virus-specific CD4+ T cell responses in chronic HCV infection in blood and liver identified by antigen-specific upregulation of CD154

2009 ◽  
Vol 47 (06) ◽  
Author(s):  
N Semmo ◽  
M Mueller ◽  
HC Spangenberg ◽  
N Kersting ◽  
T Altay ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Hcv Infection ◽  
Cd4 T Cell ◽  
Cell Responses ◽  
Chronic Hcv Infection ◽  
Chronic Hcv

Virus-specific CD4+ T cell responses in chronic HCV infection in blood and liver identified by antigen-specific upregulation of CD154

2010 ◽  
Vol 52 (6) ◽  
pp. 800-811 ◽  
Author(s):  
Mareike Mueller ◽  
Hans Christian Spangenberg ◽  
Nadine Kersting ◽  
Tayibe Altay ◽  
Hubert E. Blum ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Hcv Infection ◽  
Cd4 T Cell ◽  
Cell Responses ◽  
Chronic Hcv Infection ◽  
Chronic Hcv

HLA-A26 restricted HCV-specific CD8+ T cell responses in acute and chronic HCV infection

2006 ◽  
Vol 44 (01) ◽  
Author(s):  
T Killinger ◽  
C Neumann-Häfelin ◽  
J Timm ◽  
D McKinney ◽  
HC Spangenberg ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Hcv Infection ◽  
Cell Responses ◽  
Chronic Hcv Infection ◽  
Chronic Hcv

Differences in HCV-specific T cell responses between chronic HCV infection and HIV/HCV co-infection

2005 ◽  
Vol 35 (12) ◽  
pp. 3493-3504 ◽  
Author(s):  
Valérie Dutoit ◽  
Donatella Ciuffreda ◽  
Denis Comte ◽  
Jean-Jacques Gonvers ◽  
Giuseppe Pantaleo
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Hcv Infection ◽  
Cell Responses ◽  
Chronic Hcv Infection ◽  
Chronic Hcv

[463] DETECTION OF CD4+ T CELL RESPONSES IN PATIENTS WITH ACUTE HCV INFECTION IRRESPECTIVE OF CLINICAL OUTCOME

2007 ◽  
Vol 46 ◽  
pp. S176
Author(s):  
J. Schulze zur Wiesch ◽  
V. Kasprowicz ◽  
A.Y. Kim ◽  
T. Kuntzen ◽  
S.A. Longworth ◽  
...  
Keyword(s):  
T Cell ◽  
Clinical Outcome ◽  
T Cell Responses ◽  
Hcv Infection ◽  
Cd4 T Cell ◽  
Cell Responses ◽  
Acute Hcv ◽  
Acute Hcv Infection

Distributional characteristics of CD25 and CD127 on CD4+ T cell subsets in chronic HCV infection

2010 ◽  
Vol 155 (5) ◽  
pp. 627-634 ◽  
Author(s):  
Tao Shen ◽  
Xiangmei Chen ◽  
Qiang Xu ◽  
Fengmin Lu ◽  
Shuang Liu
Keyword(s):  
T Cell ◽  
Hcv Infection ◽  
T Cell Subsets ◽  
Cd4 T Cell ◽  
Chronic Hcv Infection ◽  
Chronic Hcv

P.002 HCV-specific CD4+ T-cell responses in HIV-1 and HCV seroconverters are influenced by the sequence of HIV-1 and HCV infection and the outcome of previous HCV infection

2009 ◽  
Vol 44 ◽  
pp. S17
Author(s):  
C.H.S.B. van den Berg ◽  
T.A. Ruys ◽  
N.M. Nanlohy ◽  
T.J.W. van de Laar ◽  
M.G.H.M. Beld ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Hcv Infection ◽  
Cd4 T Cell ◽  
Cell Responses ◽  
Hiv 1

scholarly journals Hepatitis C Virus (HCV) Sequence Variation Induces an HCV-Specific T-Cell Phenotype Analogous to Spontaneous Resolution

2009 ◽  
Vol 84 (3) ◽  
pp. 1656-1663 ◽  
Author(s):  
Victoria Kasprowicz ◽  
Yu-Hoi Kang ◽  
Michaela Lucas ◽  
Julian Schulze zur Wiesch ◽  
Thomas Kuntzen ◽  
...  
Keyword(s):  
T Cells ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
T Cell ◽  
Hcv Infection ◽  
Cell Phenotype ◽  
Cell Responses ◽  
Cognate Antigen ◽  
Chronic Hcv Infection ◽  
Chronic Hcv

ABSTRACT Hepatitis C virus (HCV)-specific CD8+ T cells in persistent HCV infection are low in frequency and paradoxically show a phenotype associated with controlled infections, expressing the memory marker CD127. We addressed to what extent this phenotype is dependent on the presence of cognate antigen. We analyzed virus-specific responses in acute and chronic HCV infections and sequenced autologous virus. We show that CD127 expression is associated with decreased antigenic stimulation after either viral clearance or viral variation. Our data indicate that most CD8 T-cell responses in chronic HCV infection do not target the circulating virus and that the appearance of HCV-specific CD127+ T cells is driven by viral variation.

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