Hedgehog-Signalling als molekulares Target beim Gallenwegskarzinom?

2011 ◽  
Vol 49 (05) ◽  
Author(s):  
T Kiesslich ◽  
J Wachter ◽  
B Alinger ◽  
M Pichler ◽  
M Ocker ◽  
...  
2017 ◽  
Vol 27 ◽  
pp. S13
Author(s):  
S. Devenport ◽  
C.M. Penton ◽  
N. Salgado ◽  
H. Wang ◽  
K. Flanigan ◽  
...  

Cells ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 98 ◽  
Author(s):  
Paola Infante ◽  
Ludovica Lospinoso Severini ◽  
Flavia Bernardi ◽  
Francesca Bufalieri ◽  
Lucia Di Marcotullio

Hedgehog signalling (Hh) is a developmental conserved pathway strongly involved in cancers when deregulated. This important pathway is orchestrated by numerous regulators, transduces through distinct routes and is finely tuned at multiple levels. In this regard, ubiquitylation processes stand as essential for controlling Hh pathway output. Although this post-translational modification governs proteins turnover, it is also implicated in non-proteolytic events, thereby regulating the most important cellular functions. The HECT E3 ligase Itch, well known to control immune response, is emerging to have a pivotal role in tumorigenesis. By illustrating Itch specificities on Hh signalling key components, here we review the role of this HECT E3 ubiquitin ligase in suppressing Hh-dependent tumours and explore its potential as promising target for innovative therapeutic approaches.


Bone ◽  
2021 ◽  
Vol 145 ◽  
pp. 115846
Author(s):  
Gillian P. Johnson ◽  
Sean Fair ◽  
David A. Hoey

2015 ◽  
Vol 11 (8) ◽  
pp. 2190-2197 ◽  
Author(s):  
Wolfgang Schmidt-Heck ◽  
Madlen Matz-Soja ◽  
Susanne Aleithe ◽  
Eugenia Marbach ◽  
Reinhard Guthke ◽  
...  

The Hedgehog signalling-driven Gli transcription factors in hepatocytes form a regulatory network identified by a fuzzy-logic modelling approach. The network explains dynamic features important for hepatocyte function and fate.


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