Hypercoagulation and Thrombophilia in Nonalcoholic Fatty Liver Disease: Mechanisms, Human Evidence, Therapeutic Implications, and Preventive Implications

2012 ◽  
Vol 32 (01) ◽  
pp. 039-048 ◽  
Author(s):  
Patrick Northup ◽  
Curtis Argo ◽  
Neeral Shah ◽  
Stephen Caldwell
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver ◽  
Therapeutic Implications ◽  
Disease Mechanisms

scholarly journals Bile Acid Receptors and the Gut–Liver Axis in Nonalcoholic Fatty Liver Disease

Cells ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 2806
Author(s):  
Rui Xue ◽  
Lianyong Su ◽  
Shengyi Lai ◽  
Yanyan Wang ◽  
Derrick Zhao ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Signaling Pathways ◽  
Disease Progression ◽  
Fatty Liver Disease ◽  
Current Understanding ◽  
Nonalcoholic Fatty Liver ◽  
Therapeutic Implications ◽  
Global Epidemic

The prevalence of nonalcoholic fatty liver disease (NAFLD) has been significantly increased due to the global epidemic of obesity. The disease progression from simple steatosis (NAFL) to nonalcoholic steatohepatitis (NASH) is closely linked to inflammation, insulin resistance, and dysbiosis. Although extensive efforts have been aimed at elucidating the pathological mechanisms of NAFLD disease progression, current understanding remains incomplete, and no effective therapy is available. Bile acids (BAs) are not only important physiological detergents for the absorption of lipid-soluble nutrients in the intestine but also metabolic regulators. During the last two decades, BAs have been identified as important signaling molecules involved in lipid, glucose, and energy metabolism. Dysregulation of BA homeostasis has been associated with NAFLD disease severity. Identification of nuclear receptors and G-protein-coupled receptors activated by different BAs not only significantly expanded the current understanding of NAFLD/NASH disease progression but also provided the opportunity to develop potential therapeutics for NAFLD/NASH. In this review, we will summarize the recent studies with a focus on BA-mediated signaling pathways in NAFLD/NASH. Furthermore, the therapeutic implications of targeting BA-mediated signaling pathways for NAFLD will also be discussed.

Nonalcoholic fatty liver disease and sarcopenia: pathophysiological connections and therapeutic implications

2020 ◽  
Vol 14 (12) ◽  
pp. 1141-1157 ◽  
Author(s):  
Tiziana Fernández-Mincone ◽  
Felipe Contreras-Briceño ◽  
Maximiliano Espinosa-Ramírez ◽  
Patricio García-Valdés ◽  
Antonio López-Fuenzalida ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver ◽  
Therapeutic Implications
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