The Relationship of Akathisia with Treatment Emergent Suicidality among Patients with First-Episode Schizophrenia Treated with Haloperidol or Risperidone

Aim: We investigated GRIN1, GRIN2A, GRIN2B and LINE-1 DNA methylation in first-episode schizophrenia patients, their nonaffected siblings and age- and sex-matched controls testing for associations between DNA methylation and exposition to childhood trauma. Materials & methods: The Childhood Trauma Questionnaire evaluated the history of childhood trauma. Genomic DNA was bisulfite converted and pyrosequencing was employed to quantify DNA methylation. Results: GRIN2A, GRIN2B and LINE-1 DNA methylation was not associated with childhood trauma in patients, siblings and controls. Siblings with childhood trauma had hypermethylation at CpG1 of GRIN1 compared with siblings without trauma. Conclusion: Childhood trauma may influence GRIN1 methylation in subjects with liability to psychosis, but not in frank schizophrenia or controls.

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Predictors of antipsychotic treatment response in patients with first-episode schizophrenia, schizoaffective and schizophreniform disorders

The British Journal of Psychiatry ◽

10.1192/bjp.185.1.18 ◽

2004 ◽

Vol 185 (1) ◽

pp. 18-24 ◽

Cited By ~ 102

Author(s):

Diana O. Perkins ◽

Jeffrey A. Lieberman ◽

Hongbin Gu ◽

Mauricio Tohen ◽

Joseph McEvoy ◽

...

Keyword(s):

Clinical Response ◽

Treatment Response ◽

Negative Symptoms ◽

Positive Symptom ◽

First Episode ◽

Antipsychotic Treatment ◽

Duration Of Untreated Psychosis ◽

First Episode Schizophrenia ◽

Relationship Of ◽

The Relationship

BackgroundDuration of untreated psychosis (DUP) may contribute to the observed heterogeneity of the treatment response in first-episode schizophrenia.AimsTo examine the relationship of DUP and premorbid function with clinical outcomes following up to 2 years of antipsychotic treatment.MethodFor a subsample (n = 191) of subjects participating in a clinical trial, DUP and premorbid function were prospectively compared with clinical response to olanzapine or haloperidol.ResultsShorter DUP and good premorbid function each independently are associated with better clinical response, including improvement in overall psychopathology and negative symptoms. Premorbid function also is associated with positive symptom, social and vocational outcomes.ConclusionsEarlier antipsychotic treatment is associated with better outcomes in first-episode schizophrenia. Poor premorbid function could indicate an illness subtype less likely to respond to antipsychotic treatment regardless of when it is instituted.

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The relationship of early premorbid adjustment with negative symptoms and cognitive functions in first-episode schizophrenia: A prospective three-year follow-up study

Psychiatry Research ◽

10.1016/j.psychres.2013.02.014 ◽

2013 ◽

Vol 209 (3) ◽

pp. 353-360 ◽

Cited By ~ 37

Author(s):

Wing Chung Chang ◽

Jennifer Yee Man Tang ◽

Christy Lai Ming Hui ◽

Gloria Hoi Yan Wong ◽

Sherry Kit Wa Chan ◽

...

Keyword(s):

Cognitive Functions ◽

Negative Symptoms ◽

First Episode ◽

Follow Up Study ◽

Premorbid Adjustment ◽

First Episode Schizophrenia ◽

Relationship Of ◽

The Relationship

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The relationship of psychosis to neuropsychological dysfunction in unmedicated first-episode schizophrenia, psychotic and non-psychotic unipolar depression, and healthy volunteers

Schizophrenia Research ◽

10.1016/s0920-9964(03)80938-6 ◽

2003 ◽

Vol 60 (1) ◽

pp. 138-139

Author(s):

S.K. Hill ◽

M.S. Keshavan ◽

J.A. Sweeney

Keyword(s):

Healthy Volunteers ◽

Unipolar Depression ◽

First Episode ◽

Neuropsychological Dysfunction ◽

First Episode Schizophrenia ◽

Relationship Of ◽

The Relationship

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O4.5. EXPLORING THE RELATIONSHIP BETWEEN SENSORY FILTERING AND COGNITION: RESULTS OF A LARGE COHORT OF ANTIPSYCHOTIC-NAïVE FIRST-EPISODE SCHIZOPHRENIA PATIENTS

Schizophrenia Bulletin ◽

10.1093/schbul/sbz021.205 ◽

2019 ◽

Vol 45 (Supplement_2) ◽

pp. S170-S171

Author(s):

Caitlyn Kruiper ◽

Birgitte Fagerlund ◽

Mette Nielsen ◽

Signe During ◽

Bjorn Ebdrup ◽

...

Keyword(s):

Large Cohort ◽

First Episode ◽

First Episode Schizophrenia ◽

The Relationship

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Predictors of outcome in first-episode schizophrenia over the first 4 years of illness

Psychological Medicine ◽

10.1017/s003329170800336x ◽

2008 ◽

Vol 38 (8) ◽

pp. 1141-1146 ◽

Cited By ~ 26

Author(s):

P. Whitty ◽

M. Clarke ◽

O. McTigue ◽

S. Browne ◽

M. Kamali ◽

...

Keyword(s):

Negative Symptoms ◽

First Episode ◽

Global Assessment Of Functioning ◽

Methodological Issues ◽

Course Of Illness ◽

Dsm Iv ◽

First Episode Schizophrenia ◽

The Relationship ◽

Positive And Negative Symptoms

BackgroundThe outcome of schizophrenia appears to be more favourable than once thought. However, methodological issues, including the reliance on diagnosis at first presentation have limited the validity of outcome studies to date.MethodWe conducted a first-episode follow-up study of 97 patients with DSM-IV schizophrenia over the first 4 years of illness. First presentation and follow-up assessments were compared using paired t tests and a forced-entry regression analysis was used to determine prognostic variables.ResultsThere were significant improvements in positive and negative symptoms and global assessment of functioning between first presentation and follow-up. At first presentation, fewer negative symptoms (t=−3.40, p<0.01), more years spent in education (t=3.25, p<0.01), and a shorter duration of untreated psychosis (DUP) (t=−2.77, p<0.01) significantly predicted a better outcome at follow-up.ConclusionsThe outcome of schizophrenia may not be as pessimistic as once thought and most patients did not display a downward deteriorating course of illness. This study supports the relationship between DUP and outcome beyond the early stages of illness.

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The relationship of neuropsychological test performance with the PANSS in antipsychotic naïve, first-episode psychosis patients

Schizophrenia Research ◽

10.1016/j.scheres.2003.07.001 ◽

2003 ◽

Author(s):

K Good

Keyword(s):

Test Performance ◽

Neuropsychological Test ◽

First Episode Psychosis ◽

First Episode ◽

Episode Psychosis ◽

Relationship Of ◽

The Relationship

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Duration of untreated psychosis and social function: 1-year follow-up study of first-episode schizophrenia

The British Journal of Psychiatry ◽

10.1192/bjp.bp.108.049718 ◽

2008 ◽

Vol 193 (3) ◽

pp. 203-209 ◽

Cited By ~ 85

Author(s):

Thomas R. E. Barnes ◽

Verity C. Leeson ◽

Stanley H. Mutsatsa ◽

Hilary C. Watt ◽

Sam B. Hutton ◽

...

Keyword(s):

Negative Symptoms ◽

Social Function ◽

First Episode ◽

Duration Of Untreated Psychosis ◽

Clinical Difference ◽

Path Analyses ◽

First Episode Schizophrenia ◽

The Relationship ◽

Positive And Negative Symptoms

BackgroundIn first-episode schizophrenia, longer duration of untreated psychosis (DUP) predicts poorer outcomes.AimsTo address whether the relationship between DUP and outcome is a direct causal one or the result of association between symptoms and/or cognitive functioning and social functioning at the same time point.MethodSymptoms, social function and cognitive function were assessed in 98 patients with first-episode schizphrenia at presentation and 1 year later.ResultsThere was no significant clinical difference between participants with short and long DUP at presentation. Linear regression analyses revealed that longer DUP significantly predicted more severe positive and negative symptoms and poorer social function at 1 year, independent of scores at presentation. Path analyses revealed independent direct relationships between DUP and social function, core negative symptoms and positive symptoms. There was no significant association between DUP and cognition.ConclusionsLonger DUP predicts poor social function independently of symptoms. The findings underline the importance of taking account of the phenomenological overlap between measures of negative symptoms and social function when investigating the effects of DUP.

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