Postnatal Weight Gain in Preterm Infants with Severe Bronchopulmonary Dysplasia

Objective. The objective was to study the risk and protective factors involved in retinal vascular development of preterm infants with retinopathy of prematurity. Methods. Between 2000 and 2017, 185 preterm infants were included in the protocol for retinopathy of prematurity. Risk factors associated with speed of retinal vascularization <0.5 disc diameter/week were studied in each of them. Results. The statistically significant variables related to retinal vascular development <0.5 DD/w were intubation days, degree 3 of bronchopulmonary dysplasia, weight gain at 4-6 weeks, avascular temporal area, gestational age, number of transfusions, sepsis, number of risk factors, apnea at birth, presence of ductus arteriosus, and days of continuous positive airway pressure therapy. After the multivariate logistic regression analysis, only three variables were found to be significant: intubation days (p=0.005), degree 3 of bronchopulmonary dysplasia (p=0.022), and weight gain at 4–6 weeks (p=0.031). Conclusion. In retinopathy of prematurity, degree 3 of bronchopulmonary dysplasia and intubation days cause delayed retinal vascular development, whereas greater postnatal weight gain favors an appropriate rate of retinal vascularization.

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Postnatal weight gain in very preterm infants: are we aiming too high?

The Lancet Child & Adolescent Health ◽

10.1016/s2352-4642(21)00247-9 ◽

2021 ◽

Author(s):

Shripada Rao ◽

Karen Simmer

Keyword(s):

Weight Gain ◽

Preterm Infants ◽

Very Preterm Infants ◽

Very Preterm ◽

Postnatal Weight Gain

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Effect of intestinal microecology on postnatal weight gain in very preterm infants in intensive care units

Gut Pathogens ◽

10.1186/s13099-021-00445-1 ◽

2021 ◽

Vol 13 (1) ◽

Author(s):

Ying-Xue Ding ◽

Shou-Ni Wang ◽

Hong Cui ◽

Li-Na Jiang

Keyword(s):

Intensive Care ◽

Weight Gain ◽

Preterm Infants ◽

Principal Components ◽

Intestinal Microflora ◽

Normal Growth ◽

Very Preterm Infants ◽

Very Preterm ◽

Stool Samples ◽

Postnatal Weight Gain

Abstract Objective To study the effect of intestinal microecology on postnatal weight gain of very preterm infants in neonatal intensive care unit (NICU). Methods Very preterm infants who met the inclusion criteria were enrolled. The subjects were divided into the extrauterine growth retardation (EUGR) group(defined as a body weight less than the 10th percentile of the corresponding gestational age or a weight loss between birth and a given time of > 2SD were considered EUGR) and normal growth group, and the growth was evaluated at 2 and 4 weeks after birth. Meanwhile, the stool samples were taken to perform16S ribosomal RNA (rRNA) high -throughput 16S rRNA sequencing of the intestinal microflora was performed on stool samples. Results A total of 22 infants were included. There was no significant difference in the alpha diversity indexes indices between the two groups at 2 weeks or 4 weeks after birth. The beta diversity analysis showed that the two groups had similar principal components of the intestinal microflora were similar between the two groups. Linear discriminant analysis (LDA) effect size (LEfSe) showed that 2 weeks after birth, the bacteria with an absolute LDA score (log10) higher than 4 included Streptococcaceae, Streptococcus, Bacteroidetes, Bacteroidales and Stenotrophomonas in the EUGR group and Enterococcaceae and Enterococcus in the control group. At the 4th week after birth, the bacteria with an absolute LDA score (log10) higher than 3 in the EUGR group includedwere Clostriaceae, Eubacteriaceae and Eubacterium. TheBy comparing the composition of the microbial community composition comparison showed, significant differences were found in the principal components of Enterococcus and Streptococcus on the family and genus levels at 2 weeks after birth. No Bifidobacterium was found in either group at 4 weeks after birth. Conclusion Intestinal microecology is different between infants with EUGR and those with normal growth. The diversity and richness of the intestinal microflora in preterm infants at the NICU are significantly insufficient and change dynamically with time, and the establishment of intestinal homeostasis is obviously delayed.

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