Prevention and Treatment of Intervertebral Disc Degeneration with Bone Marrow Derived Stem (Stromal) Cells—An in Vivo Study in Sheep

2014 ◽  
Vol 4 (1_suppl) ◽  
pp. s-0034-1376572-s-0034-1376572
Author(s):  
J. Melrose ◽  
C. Shu ◽  
A. Dart ◽  
E. C. Clarke ◽  
J. Martin ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Stromal Cells ◽  
Intervertebral Disc Degeneration ◽  
In Vivo Study ◽  
Prevention And Treatment

scholarly journals An in vivo study of the effect of c-Jun on intervertebral disc degeneration in rats

Bioengineered ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 4320-4330
Author(s):  
Ming Lei ◽  
Kangcheng Zhao ◽  
Wenbin Hua ◽  
Kun Wang ◽  
Shuai Li ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
In Vivo Study

8:42 An in vivo study of Sox9 gene therapy for intervertebral disc degeneration

2002 ◽  
Vol 2 (5) ◽  
pp. 50 ◽  
Author(s):  
Nikola Nenadovich ◽  
Frank Phillips ◽  
T.C. He ◽  
Rex Haydon ◽  
Hongwei Cheng
Keyword(s):  
Gene Therapy ◽  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
In Vivo Study ◽  
Sox9 Gene

scholarly journals Rabbit Model for in vivo Study of Intervertebral Disc Degeneration and Regeneration

2008 ◽  
Vol 44 (5) ◽  
pp. 327 ◽  
Author(s):  
Min Ho Kong ◽  
Duc H. Do ◽  
Masashi Miyazaki ◽  
Feng Wei ◽  
Sung-Hwan Yoon ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
Rabbit Model ◽  
In Vivo Study

MRI methodological development of intervertebral disc degeneration: a rabbit in vivo study at 9.4 T

2008 ◽  
Vol 26 (10) ◽  
pp. 1421-1432 ◽  
Author(s):  
Fanny Noury ◽  
Joël Mispelter ◽  
Frédéric Szeremeta ◽  
Sandra Même ◽  
Bich-Thuy Doan ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
In Vivo Study ◽  
Methodological Development

scholarly journals Unravelling the role of Mesenchymal Stem/Stromal Cells Secretome in intervertebral disc degeneration in a pro-inflammatory/degenerative ex vivo model

2020 ◽  
Author(s):  
JR Ferreira ◽  
GQ Teixeira ◽  
E Neto ◽  
C Ribeiro-Machado ◽  
AM Silva ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Stromal Cells ◽  
Intervertebral Disc Degeneration ◽  
Ex Vivo ◽  
Ex Vivo Model

Abstract The authors have withdrawn this preprint due to author disagreement.

scholarly journals Efficacy of Platelet-Rich Plasma Containing Xenogenic Adipose Tissue-Derived Stromal Cells on Restoring Intervertebral Disc Degeneration: A Preclinical Study in a Rabbit Model

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Chao Ma ◽  
Ran Wang ◽  
Dingliang Zhao ◽  
Naikun Wang ◽  
Ying Han ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Stromal Cells ◽  
Signal Intensity ◽  
Intervertebral Disc Degeneration ◽  
Platelet Rich Plasma ◽  
Rabbit Model ◽  
Control Group ◽  
Arterial Blood

Objective. Platelet-rich plasma (PRP) containing multiple growth factors is a promising strategy for disc degeneration. Thus, this study hypothesizes that the combination of PRP and adipose tissue-derived stromal cells (ADSCs) may repair degenerative disc more effectively than using each one of them alone. Methods. The model of early intervertebral disc degeneration was induced by annular puncture in the New Zealand rabbit. Autologous PRP was extracted from fresh arterial blood by using two centrifugation techniques. ADSC was offered by the Center for Clinic Stem Cell Research. Four weeks after the first experiment, PRP or ADSCs or a combination of PRP and ADSCs was injected into the punctured intervertebral disc. Four weeks later, disc height and signal intensity on T2-weighted magnetic resonance imaging (MRI) were assessed. Results. One month after puncture, we detected relatively narrow discs and lower signal intensity in MRI T2-weighted images. At four weeks after injection, the PRP-ADSC group statistically significantly restored discs, compared with PRP, ADSCs, or negative control group. Conclusions. The combination of PRP and ADSCs shows an effective potential to restore degenerated intervertebral discs in the rabbit.

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