The Reaction of 2-(Acylamino)benzonitriles with Primary Aromatic Amines: A Convenient Synthesis of 2-Substituted 4-(Arylamino)quinazolines
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2-Substituted 4-(arylamino)quinazolines were prepared from 2-(acylamino)benzonitriles and primary arylamines by refluxing in either ethanol using trifluoroacetic acid as a catalyst or acetic acid. The 2-aminobenzonitrile was acylated by reaction with anhydrides, isocyanates, or ethyl chloroformate at room temperature.
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1981 ◽
Vol 36
(4)
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pp. 501-504
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1997 ◽
Vol 52
(11)
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pp. 1401-1412
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2009 ◽
Vol 48
(6)
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pp. 1114-1116
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