Antiestrogenic effects of the polyaromatic hydrocarbon 3-methylcholanthrene in the rat uterus and mammary gland

2015 ◽  
Vol 122 (03) ◽  
Author(s):  
G Kretzschmar ◽  
J Helle ◽  
A Keiler ◽  
O Zierau ◽  
G Vollmer
Keyword(s):  
Mammary Gland ◽  
Polyaromatic Hydrocarbon ◽  
Rat Uterus ◽  
Antiestrogenic Effects

Differential regulation of TGF-β2 by hormones in rat uterus and mammary gland

1996 ◽  
Vol 32 (2) ◽  
pp. 125-144 ◽  
Author(s):  
Sara L. Schneider ◽  
Sandra O. Gollnick ◽  
Catherine Grande ◽  
James E. Pazik ◽  
Thomas B. Tomasi
Keyword(s):  
Mammary Gland ◽  
Differential Regulation ◽  
Rat Uterus

130. Comparison of the effects of tantoxifen and monohydroxytamoxifen in the rat uterus and mammary gland

1978 ◽  
Vol 9 (9) ◽  
pp. 840
Author(s):  
V.C. Jordan ◽  
K.E. Naylor
Keyword(s):  
Mammary Gland ◽  
Rat Uterus

Action of [1,6-Di-alanine]-oxytocin and [1,6-Di-serine]-oxytocin on the rat uterus and mammary gland in vitro

1970 ◽  
Vol 9 (2) ◽  
pp. 239-245 ◽  
Author(s):  
Ivo Poláček ◽  
Ivan Krejčí ◽  
Hans Nesvadba ◽  
Josef Rudinger
Keyword(s):  
Mammary Gland ◽  
Rat Uterus

THE EFFECTS OF HIGHLY PURIFIED POSTERIOR PITUITARY PRINCIPLES ON THE LACTATING MAMMARY GLAND OF THE RABBIT

1953 ◽  
Vol 9 (2) ◽  
pp. 232-235 ◽  
Author(s):  
B. A. CROSS ◽  
H. B. VAN DYKE
Keyword(s):  
Mammary Gland ◽  
Posterior Pituitary ◽  
Milk Ejection ◽  
Rat Uterus ◽  
Lactating Mammary Gland

1. The milk-ejection activity of highly purified oxytocic and vasopressor-antidiuretic (ADH) polypeptides was determined on the intact mammary gland of the lactating rabbit. 2. When assayed in this way, 100 units of vasopressin-ADH had an activity represented by 17 units of oxytocin. 3. The lactating rabbit mammary gland is more sensitive to oxytocin than the rat uterus, and appears to be the best means at present available for assessing milk-ejection activity.

The preparation and metabolic fate of tritiated Nα-acetyl[2-O-methyltyrosine]oxytocin - An inhibitor of the uterotonic action of oxytocin

1979 ◽  
Vol 44 (9) ◽  
pp. 2702-2709
Author(s):  
Vera Bojanovska ◽  
Tomislav Barth ◽  
Bohuslav Černý ◽  
Karel Hauzer ◽  
Karel Jošt
Keyword(s):  
Biological Activity ◽  
Mammary Gland ◽  
Specific Radioactivity ◽  
Subcellular Fractions ◽  
Metabolic Fate ◽  
Rat Uterus ◽  
Peptide Bonds ◽  
Human Pregnancy ◽  
Metabolic Products

An inhibitor of the uterotonic action of oxytocin-[CH3CO-3H] [2-O-methyltyrosine]oxytocin - having biological activity and a specific radioactivity of 3-7 Ci/mmol was prepared by the reaction of [2-O-methyltyrosine]oxytocin with 2,2'-3H2-acetanhydride. The analogue was stable in human pregnancy serum. Chymotrypsin split the Tyr(Me)-Ile and Leu-GlyNH2 peptide bonds. In the presence of subcellular fractions of homogenates of the rat uterus and mammary gland, several metabolic products were formed from the analogue.

Estrogenic and Antiestrogenic Effects of Clomiphene, MER-25 and CN-55,945-27 on the Rat Uterus and Vagina

Endocrinology ◽  
1968 ◽  
Vol 82 (1) ◽  
pp. 69-74 ◽  
Author(s):  
JOAN R. WOOD ◽  
T. RANDALL WRENN ◽  
JOEL BITMAN
Keyword(s):  
Rat Uterus ◽  
Antiestrogenic Effects

Electron microscopic studies on ultrathin frozen sections of lactating mouse mammary gland

1978 ◽  
Vol 36 (2) ◽  
pp. 46-47
Author(s):  
Jan Zarzycki ◽  
Joseph Szroeder
Keyword(s):  
Mammary Gland ◽  
Protein Denaturation ◽  
Chemical Constituents ◽  
Freeze Substitution ◽  
Electron Microscopic Examination ◽  
Mouse Mammary Gland ◽  
Electron Microscopic ◽  
Preparation Methods ◽  
Microscopic Studies ◽  
Ultrathin Frozen Sections

The mammary gland ultrastructure in various functional states is the object of our investigations. The material prepared for electron microscopic examination by the conventional chemical methods has several limitations, the most important are the protein denaturation processes and the loss of large amounts of chemical constituents from the cells. In relevance to this,one can't be sure about a degree the observed images are adequate to the realy ultrastructure of a living cell. To avoid the disadvantages of the chemical preparation methods,some autors worked out alternative physical methods based on tissue freezing / freeze-drying, freeze-substitution, freeze-eatching techniqs/; actually the technique of cryoultraraicrotomy,i,e.cutting ultrathin sections from deep frozen specimens is assented as a complete alternative method. According to the limitations of the routine plastic embbeding methods we were interested to analize the mammary gland ultrastructure during lactation by the cryoultramicrotomy method.

The effect of bromocriptine on mammary-gland ultrastructure of hyperprolactinemic rats

1984 ◽  
Vol 42 ◽  
pp. 204-205
Author(s):  
I.C. Murray
Keyword(s):  
Mammary Gland ◽  
Dopamine Agonist ◽  
Alveolar Epithelium ◽  
Mammary Glands ◽  
Female Rats ◽  
Control Group ◽  
Cell Hyperplasia ◽  
Once Daily ◽  
Long Evans

In women, hyperprolactinemia is often due to a prolactin (PRL)-secreting adenoma or PRL cell hyperplasia. RRL excess stimulates the mammary glands and causes proliferation of the alveolar epithelium. Bromocriptine, a dopamine agonist, inhibits PRL secretion and is given to women to treat nonpuerperal galactorrhea. Old female rats have been reported to have PRL cell hyperplasia or adenoma leading to PRL hypersecretion and breast stimulation. Herein, we describe the effect of bromocriptine and consequently the reduction in serum PRL levels on the ultrastructure of rat mammary glands.Female Long-Evans rats, 23 months of age, were divided into control and bromocriptine-treated groups. The control animals were injected subcutaneously once daily with a 10% ethanol vehicle and were later divided into a normoprolactinemic control group with serum PRL levels under 30 ng/ml and a hyperprolactinemic control group with serum PRL levels above 30 ng/ml.

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