Clinical Experience of Using Cortical Auditory Evoked Potentials in the Treatment of Infant Hearing Loss in Australia

Purpose: To determine if one-octave multitone (MT) stimuli increase the amplitude of cortical auditory-evoked potentials (CAEPs) in individuals with a hearing loss when compared to standard pure-tone (PT) stimuli and narrow-band noise (NBN). Research Design: CAEPs were obtained from 16 hearing-impaired adults in response to PT and MT auditory stimuli centered around 0.5, 1, 2, and 4 kHz and NBN centered around 1 and 2 kHz. Hearing impairment ranged from a mild to a moderate hearing loss in both ears. Auditory stimuli were monaurally delivered through insert earphones at 10 and 20 dB above threshold. The root mean square amplitude of the CAEP and the detectability of the responses using Hotelling’s T2 were calculated and analyzed. Results: CAEP amplitudes elicited with MT stimuli were on average 29% larger than PT stimuli for frequencies centered around 1, 2, and 4 kHz. No significant difference was found for responses to 0.5-kHz stimuli. Significantly higher objective detection scores were found for MT when compared to PT. For the 1- and 2-kHz stimuli, the CAEP amplitudes to NBN were not significantly different to those evoked by PT but a significant difference was found between MT stimuli and both NBN and PT. The mean detection sensitivity of MT for the four frequencies was 80% at 10 dB SL and 95% at 20 dB SL, and was comparable with detection sensitivities observed in normal-hearing participants. Conclusions: Using MT stimuli when testing CAEPs in adults with hearing impairment showed larger amplitudes and a higher objective detection sensitivity compared to using traditional PT stimuli for frequencies centered around 1, 2, and 4 kHz. These findings suggest that MT stimuli are a clinically useful tool to increase the efficiency of frequency-specific CAEP testing in adults with hearing impairment.

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Effects of Directional Microphone and Noise Reduction on Subcortical and Cortical Auditory-Evoked Potentials in Older Listeners With Hearing Loss

Ear and Hearing ◽

10.1097/aud.0000000000000847 ◽

2020 ◽

Vol 41 (5) ◽

pp. 1282-1293

Author(s):

Christopher Slugocki ◽

Francis Kuk ◽

Petri Korhonen

Keyword(s):

Hearing Loss ◽

Evoked Potentials ◽

Noise Reduction ◽

Auditory Evoked Potentials ◽

Directional Microphone ◽

Cortical Auditory Evoked Potentials

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P19-2 Cortical auditory evoked potentials (CAEP) as a clinical tool in evaluation of hearing loss

Clinical Neurophysiology ◽

10.1016/s1388-2457(10)60880-2 ◽

2010 ◽

Vol 121 ◽

pp. S215

Author(s):

H. Lindehammar ◽

L. Hergils ◽

A. Sharma

Keyword(s):

Hearing Loss ◽

Evoked Potentials ◽

Auditory Evoked Potentials ◽

Clinical Tool ◽

Cortical Auditory Evoked Potentials

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Threshold Estimation Using “Chained Stimuli” for Cortical Auditory Evoked Potentials in Individuals With Normal Hearing and Hearing Impairment

American Journal of Audiology ◽

10.1044/2018_aja-ind50-18-0090 ◽

2019 ◽

Vol 28 (2S) ◽

pp. 428-436

Author(s):

Mohan Kumar Kalaiah ◽

Sanjana Poovaiah ◽

Usha Shastri

Keyword(s):

Hearing Loss ◽

Evoked Potentials ◽

Auditory Evoked Potentials ◽

Normal Hearing ◽

Testing Time ◽

Threshold Estimation ◽

Behavioral Threshold ◽

Hearing Sensitivity ◽

The Difference ◽

Cortical Auditory Evoked Potentials

Purpose We investigated the utility of chained stimuli for threshold estimation using cortical auditory evoked potentials (CAEPs) in individuals with normal hearing sensitivity and hearing loss. The effect of the order of frequency in chained stimuli on CAEPs was also studied. Method Seventeen individuals with normal hearing and 17 individuals with mild to severe sensorineural hearing loss participated in the study. In individuals with normal hearing, CAEPs were recorded at 80 dB nHL for 4 chained stimuli with different orders of frequencies within them (Chained Stimuli 1 [CS1]: 500, 1000, 2000, 4000 Hz; Chained Stimuli 2: 4000, 2000, 1000, 500 Hz; Chained Stimuli 3: 500, 2000, 1000, 4000 Hz; Chained Stimuli 4: 4000, 1000, 2000, 500 Hz). CAEP threshold estimation was carried out using CS1 in both groups and was compared with behavioral pure-tone thresholds. Results CS1 elicited the largest amplitude responses at low and mid frequencies, whereas all 4 stimuli elicited similar amplitude responses at high frequencies. CAEP thresholds were generally within 10–20 dB above the participants' behavioral threshold in both groups. The difference between CAEP threshold and behavioral threshold was less for individuals with hearing loss compared to individuals with normal hearing. There was a significant positive correlation between CAEP threshold and behavioral threshold at all the frequencies. Conclusions CS1 could be used to elicit CAEPs for threshold estimation in adult participants with normal hearing and hearing loss of varied degrees with theoretically reduced testing time. The actual time reduction using chained stimuli and the correction factor to be applied to estimate behavioral threshold can be studied in future investigations.

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Detection Rates of Cortical Auditory Evoked Potentials at Different Sensation Levels in Infants with Sensory/Neural Hearing Loss and Auditory Neuropathy Spectrum Disorder

Seminars in Hearing ◽

10.1055/s-0035-1570330 ◽

2016 ◽

Vol 37 (01) ◽

pp. 053-061 ◽

Cited By ~ 3

Author(s):

Hsiuwen Chang ◽

Teresa Ching ◽

Sanna Hou ◽

Kirsty Gardner-Berry

Keyword(s):

Hearing Loss ◽

Evoked Potentials ◽

Auditory Evoked Potentials ◽

Auditory Neuropathy ◽

Spectrum Disorder ◽

Detection Rates ◽

Auditory Neuropathy Spectrum Disorder ◽

Sensory Neural ◽

Cortical Auditory Evoked Potentials ◽

Sensory Neural Hearing Loss

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Cortical Auditory Evoked Potentials in Children with a Hearing Loss: A Pilot Study

International Journal of Pediatrics ◽

10.1155/2012/250254 ◽

2012 ◽

Vol 2012 ◽

pp. 1-8 ◽

Cited By ~ 5

Author(s):

Amineh Koravand ◽

Benoît Jutras ◽

Maryse Lassonde

Keyword(s):

Hearing Loss ◽

Evoked Potentials ◽

Hearing Aids ◽

Auditory Processing ◽

Auditory Evoked Potentials ◽

Group Differences ◽

Central Auditory Processing ◽

Significant Group ◽

Children With Hearing Loss ◽

Cortical Auditory Evoked Potentials

Objective. This study examined the patterns of neural activity in the central auditory system in children with hearing loss.Methods. Cortical potentials and mismatch responses (MMRs) were recorded from ten children aged between 9 and 10 years: five with hearing loss and five with normal hearing in passive oddball paradigms using verbal and nonverbal stimuli.Results. Results indicate a trend toward larger P1 amplitude, a significant reduction in amplitude, and latency of N2 in children with hearing loss compared to control. No significant group differences were observed for the majority of the MMRs conditions.Conclusions. Data suggest that the reduced auditory input affects the pattern of cortical-auditory-evoked potentials in children with a mild to moderately severe hearing loss. Results suggest maturational delays and/or deficits in central auditory processing in children with hearing loss, as indicated by the neurophysiological markers P1 and N2. In contrast, negative MMR data suggest that the amplification provided by the hearing aids could have allowed children with hearing loss to develop adequate discriminative abilities.

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Cortical Auditory-Evoked Potentials (CAEPs) in Adults in Response to Filtered Speech Stimuli

Journal of the American Academy of Audiology ◽

10.3766/jaaa.24.9.5 ◽

2013 ◽

Vol 24 (09) ◽

pp. 807-822 ◽

Cited By ~ 11

Author(s):

Lyndal Carter ◽

Harvey Dillon ◽

John Seymour ◽

Mark Seeto ◽

Bram Van Dun

Keyword(s):

Hearing Loss ◽

Evoked Potentials ◽

Hearing Aids ◽

Auditory Evoked Potentials ◽

Hearing Aid ◽

Speech Sounds ◽

Sensation Level ◽

Behavioral Threshold ◽

Speech Stimuli ◽

Cortical Auditory Evoked Potentials

Background: Previous studies have demonstrated that cortical auditory-evoked potentials (CAEPs) can be reliably elicited in response to speech stimuli in listeners wearing hearing aids. It is unclear, however, how close to the aided behavioral threshold (i.e., at what behavioral sensation level) a sound must be before a cortical response can reliably be detected. Purpose: The purpose of this study was to systematically examine the relationship between CAEP detection and the audibility of speech sounds (as measured behaviorally), when the listener is wearing a hearing aid fitted to prescriptive targets. A secondary aim was to investigate whether CAEP detection is affected by varying the frequency emphasis of stimuli, so as to simulate variations to the prescribed gain-frequency response of a hearing aid. The results have direct implications for the evaluation of hearing aid fittings in nonresponsive adult clients, and indirect implications for the evaluation of hearing aid fittings in infants. Research Design: Participants wore hearing aids while listening to speech sounds presented in a sound field. Aided thresholds were measured, and cortical responses evoked, under a range of stimulus conditions. The presence or absence of CAEPs was determined by an automated statistic. Study Sample: Participants were adults (6 females and 4 males). Participants had sensorineural hearing loss ranging from mild to severe-profound in degree. Data Collection and Analysis: Participants' own hearing aids were replaced with a test hearing aid, with linear processing, during assessments. Pure-tone thresholds and hearing aid gain measurements were obtained, and a theoretical prediction of speech stimulus audibility for each participant (similar to those used for audibility predictions in infant hearing aid fittings) was calculated. Three speech stimuli, (/m/, /t/, and /g/) were presented aided (monaurally, nontest ear occluded), free field, under three conditions (+4 dB/octave, −4 dB/octave, and without filtering), at levels of 40, 50, and 60 dB SPL (measured for the unfiltered condition). Behavioral thresholds were obtained, and CAEP recordings were made using these stimuli. The interaction of hearing loss, presentation levels, and filtering conditions resulted in a range of CAEP test behavioral sensation levels (SLs), from −25 to +40 dB. Results: Statistically significant CAEPs (p < .05) were obtained for virtually every presentation where the behavioral sensation level was >10 dB, and for only 5% of occasions when the sensation level was negative. In these (“false-positive”) cases, the greatest (negative) sensation level at which a CAEP was judged to be present was −6 dB SL. Conclusions: CAEPs are a sensitive tool for directly evaluating the audibility of speech sounds, at least for adult listeners. CAEP evaluation was found to be more accurate than audibility predictions, based on threshold and hearing aid response measures.

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Age Effects on Neural Representation and Perception of Silence Duration Cues in Speech

Journal of Speech Language and Hearing Research ◽

10.1044/2018_jslhr-h-ascc7-18-0076 ◽

2019 ◽

Vol 62 (4S) ◽

pp. 1099-1116 ◽

Cited By ~ 5

Author(s):

Lindsey Roque ◽

Casey Gaskins ◽

Sandra Gordon-Salant ◽

Matthew J. Goupell ◽

Samira Anderson

Keyword(s):

Hearing Loss ◽

Regression Analysis ◽

Linear Regression ◽

Evoked Potentials ◽

Auditory Evoked Potentials ◽

Linear Regression Analysis ◽

Auditory Brainstem ◽

Normal Hearing ◽

Group Differences ◽

Cortical Auditory Evoked Potentials

Purpose Degraded temporal processing associated with aging may be a contributing factor to older adults' hearing difficulties, especially in adverse listening environments. This degraded processing may affect the ability to distinguish between words based on temporal duration cues. The current study investigates the effects of aging and hearing loss on cortical and subcortical representation of temporal speech components and on the perception of silent interval duration cues in speech. Method Identification functions for the words DISH and DITCH were obtained on a 7-step continuum of silence duration (0–60 ms) prior to the final fricative in participants who are younger with normal hearing (YNH), older with normal hearing (ONH), and older with hearing impairment (OHI). Frequency-following responses and cortical auditory-evoked potentials were recorded to the 2 end points of the continuum. Auditory brainstem responses to clicks were obtained to verify neural integrity and to compare group differences in auditory nerve function. A multiple linear regression analysis was conducted to determine the peripheral or central factors that contributed to perceptual performance. Results ONH and OHI participants required longer silence durations to identify DITCH than did YNH participants. Frequency-following responses showed reduced phase locking and poorer morphology, and cortical auditory-evoked potentials showed prolonged latencies in ONH and OHI participants compared with YNH participants. No group differences were noted for auditory brainstem response Wave I amplitude or Wave V/I ratio. After accounting for the possible effects of hearing loss, linear regression analysis revealed that both midbrain and cortical processing contributed to the variance in the DISH–DITCH perceptual identification functions. Conclusions These results suggest that age-related deficits in the ability to encode silence duration cues may be a contributing factor in degraded speech perception. In particular, degraded response morphology relates to performance on perceptual tasks based on silence duration contrasts between words.

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