Contrast enhanced ultrasound as a first line imaging method in the evaluation of FLL in daily practice. A large monocentric experience.

2016 ◽  
Vol 37 (S 01) ◽  
Author(s):  
TV Moga ◽  
CS Ivascu ◽  
C Pienar ◽  
A Popescu ◽  
R Sirli ◽  
...  
Keyword(s):  
Daily Practice ◽  
Imaging Method ◽  
Contrast Enhanced Ultrasound ◽  
First Line ◽  
Contrast Enhanced ◽  
Line Imaging

scholarly journals Characterization of Focal Liver Lesions using Contrast Enhanced Ultrasound as a First Line Method: a Large Monocentric Experience

2014 ◽  
Vol 23 (1) ◽  
pp. 57-63 ◽  
Author(s):  
Ioan Sporea ◽  
Alina Martie ◽  
Simona Bota ◽  
Roxana Sirli ◽  
Alina Popescu ◽  
...  
Keyword(s):  
Focal Liver Lesions ◽  
Imaging Method ◽  
Liver Lesions ◽  
Contrast Enhanced Ultrasound ◽  
First Line ◽  
Clear Cut ◽  
Contrast Enhanced ◽  
Line Imaging ◽  
Conclusive Diagnosis

Aim: To present a large monocentric experience in the characterization of focal liver lesions (FLLs) using Contrast Enhanced Ultrasound (CEUS).Method: A retrospective study was performed in the Gastroenterology and Hepatology Department, Timisoara, including 1100 patients with 1329 FLLs evaluated between September 2009 and January 2013. A CEUS examination was considered conclusive if the FLL respected the typical enhancement pattern as described in the EFSUMB Guidelines.Results: From the 1329 FLLs, CEUS was conclusive for a specific pathology in 1102 cases (82.9%). For the differentiation of benign/malignant lesions, CEUS reached a conclusive diagnosis in 1196 (90%) cases. The percentage of conclusive CEUS examinations was significantly higher in patients without chronic liver disease as compared with those with chronic hepatopathies: 87.3% vs. 74.4% (p<0.0001).Conclusion: CEUS patterns of enhancement fell into clear cut specific diagnostic patterns in 83% of the FLLs discovered by US, and into clear cut benign versus malignant patterns in 90% of the cases. For this reason, we can strongly recommend CEUS as a first line imaging method to characterize FLLs found at US, at least in centers with a good experience in CEUS.

scholarly journals Contrast-Enhanced Ultrasound for the Characterization of Malignant versus Benign Focal Liver Lesions in a Prospective Multicenter Experience – The SRUMB Study

2019 ◽  
Vol 28 ◽  
pp. 191-196
Author(s):  
Ioan Sporea ◽  
Daniela Larisa Săndulescu ◽  
Roxana Şirli ◽  
Alina Popescu ◽  
Mirela Danilă ◽  
...  
Keyword(s):  
Predictive Value ◽  
Real Life ◽  
Daily Practice ◽  
Focal Liver Lesions ◽  
Imaging Method ◽  
Liver Lesions ◽  
Contrast Enhanced Ultrasound ◽  
Contrast Enhanced Ct ◽  
Contrast Enhanced ◽  
Line Imaging

Aim: This study evaluated the accuracy of contrast-enhanced ultrasound (CEUS) for the differential diagnosis of benign vs. malignant focal liver lesions (FLL) in a real-life, multicenter experience. Methods: This prospective study, including 14 Romanian centers, was performed over a 6 year period (February 2011- April 2017) and included 2062 FLLs assessed by CEUS. Inclusion criteria were: newly diagnosed FLL on B-mode ultrasound, less than three lesions/patient, all FLLs evaluated by CEUS and by a second-line imaging technique (contrast enhanced CT or contrast enhanced MRI) or histology, considered as reference. The trial was registered in clinicaltrials.gov (Identifier NCT01329458). Results: From the 2062 FLLs included in the study, 57.2% (1179) were malignant and 42.8% (883) were benign. CEUS had 83.9% sensitivity (Se), 97.8% specificity (Sp), 98.1% positive predictive value (PPV), 82.2% negative predictive value (NPV) and a diagnostic accuracy (Ac) of 89.9% for the positive diagnosis of malignant lesions. For the benign lesions, CEUS had 97.8% Se, 83.9% Sp, 82.2% PPV, 98.1% NPV 89.9% Ac. The diagnostic performance of CEUS for hepatocellular carcinoma was 76.6% Se, 98.4% Sp, and 91.2% Ac; for hemangioma: 89.2% Se, 99% Sp, and 96.9% Ac and for metastases: 90.9% Se, 98.4% Sp, and 96.9% Ac. Conclusions: CEUS proved a high accuracy in differentiating the malignant vs. benign character of a FLL. It can be confidently used as a first line imaging method in daily practice.

Contrast-Enhanced Ultrasound of Benign Focal Liver Lesions

2018 ◽  
Vol 40 (01) ◽  
pp. 12-29 ◽  
Author(s):  
Christoph Dietrich
Keyword(s):  
Liver Tumors ◽  
Diagnostic Workup ◽  
Focal Liver Lesions ◽  
Liver Lesions ◽  
Contrast Enhanced Ultrasound ◽  
First Line ◽  
Benign Liver Tumors ◽  
Contrast Enhanced ◽  
Line Imaging ◽  
Benign Liver

AbstractThe diagnostic handling of benign focal liver lesions (FLLs) is a challenge and it is difficult to avoid over- and underdiagnosis. Conventional B-mode ultrasound and contrast-enhanced ultrasound (CEUS) are the first-line imaging methods to detect and characterize FLLs. This CME article discusses the diagnostic workup of benign liver tumors.

scholarly journals Contrast-Enhanced Ultrasound (CEUS) in Non-Traumatic Abdominal Emergencies

2020 ◽  
Vol 06 (03) ◽  
pp. E76-E86
Author(s):  
Diletta Cozzi ◽  
Simone Agostini ◽  
Elena Bertelli ◽  
Michele Galluzzo ◽  
Emanuela Papa ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Ultrasound Imaging ◽  
Acute Inflammation ◽  
Emergency Setting ◽  
Contrast Enhanced Ultrasound ◽  
First Line ◽  
Additional Information ◽  
Contrast Enhanced ◽  
Conventional Ultrasound ◽  
Abdominal Emergencies

AbstractConventional ultrasound imaging (US) is the first-line investigation in acute non-traumatic abdominal emergencies, but sometimes it needs further examinations, such as computed tomography (CT), to reach a certain diagnosis. Contrast-enhanced ultrasound (CEUS), through injection of contrast medium, may provide the radiologist with additional information that could not be investigated with baseline US. It could help reach a diagnosis and rapidly determine the proper therapy in an emergency setting. The purpose of this review is to explain and illustrate the various possibilities and limitations of CEUS in acute non-traumatic abdominal diseases, in particular acute inflammation, parenchymal infarcts, and hemorrhages.

scholarly journals Splenogonadal fusion evaluation using Contrast Enhanced Ultrasound and Elastography. A case report.

2019 ◽  
Vol 21 (3) ◽  
pp. 356
Author(s):  
Sergio Grosu ◽  
Johannes Rübenthaler ◽  
Thomas Knösel ◽  
Matthias Trottmann ◽  
Julian Marcon ◽  
...  
Keyword(s):  
Case Report ◽  
Imaging Modality ◽  
Shear Wave Elastography ◽  
Splenic Tissue ◽  
Pathologic Examination ◽  
First Line ◽  
Splenogonadal Fusion ◽  
Rare Congenital Anomaly ◽  
Contrast Enhanced ◽  
Line Imaging

We present the case of splenogonadal fusion in a 53-year-old male patient assessed by ultrasound and MRI, confirmed by pathologic examination. In addition to B-mode and colour-coded Doppler ultrasound, shear wave elastography and CEUS were performed and are presented in detail. Splenogonadal fusion is a rare congenital anomaly presumably caused by an abnormal attachment of splenic tissue to the gonad during gestation. Diagnosis is challenging for clinicians and in unclear cases splenogonadal fusion might cause unnecessary orchiectomies with benign pathologic results. Ultrasound is the first-line imaging modality in the diagnosis of testicular pathologies. This case report summarizes all available modern ultrasound imagingtechnologies and highlights the possibilities for the diagnosis of splenogonadal fusion.

scholarly journals Clinical and ultrasound characteristics of virilizing ovarian tumors in pre- and postmenopausal patients: a single tertiary center experience

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Mi Zou ◽  
Rong Chen ◽  
Yahong Wang ◽  
Yonglan He ◽  
Ying Wang ◽  
...  
Keyword(s):  
Transvaginal Ultrasound ◽  
Serum Testosterone ◽  
Ovarian Tumors ◽  
Imaging Method ◽  
First Line ◽  
College Hospital ◽  
Medical College ◽  
Tertiary Center ◽  
Line Imaging ◽  
Endocrine Symptoms

Abstract Background A virilizing ovarian tumor (VOT) is a rare cause of hyperandrogenism in pre- and postmenopausal women. Although transvaginal ultrasound is considered as the first-line imaging method for ovarian tumors, it is examiner-dependent. We aimed to summarize the clinical and ultrasound manifestations of VOTs to help establish the diagnosis with emphasis on those causing diagnostic difficulty. Method We retrospectively identified 31 patients with VOTs who underwent surgery at Peking Union Medical College Hospital. Results Patients with VOTs were predominantly premenopausal. All patients showed androgenic manifestations with serum testosterone levels elevated to varying degrees. The tumor size of VOTs was significantly correlated with age (P < 0.001). The VOTs in the postmenopausal group were significantly smaller than those in the premenopausal group (median 1.8 cm [range, 1.3–4.8 cm] vs 4.5 cm [range, 0.7–11.9 cm]; P = 0.018). Twenty-seven out of 31 VOTs were successfully identified by ultrasound. On ultrasound, VOTs are mostly solid and hypoechoic masses with enhanced vascularity. Four VOTs (0.7–1.5 cm) were radiologically negative, and they were the smallest among all patients. Conclusion Patients with VOTs showed androgenic manifestations with varying degrees of hyperandrogenemia. Older patients tend to have smaller VOTs. Ultrasound is an effective method for the detection of VOTs. Some VOTs can be very small and difficult to visualize radiologically, especially in postmenopausal patients. Examiners must remain vigilant about very small VOTs on the basis of endocrine symptoms.

scholarly journals Meta-Analysis of Contrast Enhanced Ultrasound in Judging Benign and Malignant Thyroid Tumors

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Qing Wan ◽  
Peng Cao ◽  
Jing Liu
Keyword(s):  
Meta Analysis ◽  
Diagnostic Methods ◽  
Imaging Method ◽  
Endocrine Tumors ◽  
Diagnostic Efficiency ◽  
Thyroid Tumors ◽  
Contrast Enhanced Ultrasound ◽  
Imaging Methods ◽  
Imaging Characteristics ◽  
Contrast Enhanced

In recent years, the incidence of thyroid cancer (TC) patients has gradually increased, and it ranks first among all endocrine tumors. TC has no obvious characteristics at the initial stage of onset. Thyroid tumors (TT) have formed when they are discovered, and they are easy to see when they are diagnosed. The disease is confused, so it is necessary to rely on imaging methods for tumor diagnosis. Contrast-enhanced ultrasound (CEUS), as the most commonly used imaging method in current clinical testing, is simple, safe, highly sensitive, can accurately display tumor conditions, and has high clinical value in the judgment of TC tumors. This article uses meta-analysis to select 63 published studies on CEUS to determine benign and malignant (BAM) TT to analyze and explore its clinical application value. This article understands the analysis of BAM TT and its diagnostic methods, clarifies the diagnostic efficiency of CEUS for TT, imaging methods, and imaging characteristics, and uses statistical analysis to analyze its heterogeneity. In this paper, the meta-analysis of CEUS in judging BAM TT is mainly based on references. The sensitivity, specificity, and difference of CEUS in diagnosing BAM TT are analyzed. Real-time elastography (RTE) is the comparison experiment object, and CEUS is used to compare the diagnostic efficiency, pathological results, and diagnostic efficiency of thyroid nodules in CEUS mode. The results of the study show that the nodule with higher diagnostic sensitivity is the echo feature, with a sensitivity of 97.73%, followed by the halo feature, with a sensitivity of 86.36%. In terms of diagnostic specificity, the boundary feature is the most specific. The specificity is 89.47%. In the judgment of BAM tumor nodules, the most obvious difference is the echo feature, which is as high as 14.09, followed by the acoustic halo feature, and the difference is 10.65.

scholarly journals Correlation between Contrast-Enhanced Ultrasound and Microvessel Density via CD31 and CD34 in a rabbit VX2 lung peripheral tumor model

2018 ◽  
Vol 1 (1) ◽  
pp. 37 ◽  
Author(s):  
Jin Xing ◽  
Wen He ◽  
Yi-Wen Ding ◽  
Yang Li ◽  
Yan-Dong Li
Keyword(s):  
Tumor Angiogenesis ◽  
Microvessel Density ◽  
Vascular Endothelial Cells ◽  
Tumor Model ◽  
Imaging Method ◽  
Contrast Enhanced Ultrasound ◽  
Rabbit Lung ◽  
Contrast Enhanced ◽  
Vx2 Tumor ◽  
The Right

Aim: To evaluate the tumor angiogenesis in lung peripheral VX2 tumor model by contrast-enhanced ultrasound (CEUS) and to determine the correlation between CEUS parameters and microvessel density (MVD) calculated via CD31 and CD34 expression.Material and methods: VX2 pulmonary tumors were created in eight Japanese white rabbits by implanting a VX2 sarcoma into the lower portion of the right lung through ultrasound guidance. Tumors were allowed to grow for 14-21 days to achieve a diameter of 7-15 mm, and were examined by CEUS using a SonoVue contrast agent. The results were recorded as digital video images, and the time-intensity curves and hemodynamic parameters were analyzed. Pathological tumor specimens were immediately obtained after the ultrasound examinations. Tumor specimens were stained with hematoxylin and eosin (H&E) and expressed as CD31 and CD34. The different endothelial cell markers were determined by immunohistochemical staining. MVD was calculated via CD 31 and CD34, and the relationship between CEUS parameters and MVD was analyzed.Results: Two distinct types of microvessels were identified in lung peripheral VX2 tumors: differentiated (CD34+) and undifferentiated (CD31+) vessels. A significant correlation was found between CEUS parameters and undifferentiated MVD (CD31+ vessels) in lung peripheral VX2 tumors (p<0.05). A reverse correlation was observed between different MVDs.Conclusions: Two different degrees of differentiation of vascular endothelial cells (CD31 and CD34) exist in the rabbit lung peripheral VX2 tumor model. CD31 MVD can more effectively evaluate tumor angiogenesis compared with CD34 MVD. CEUS, as a non-invasive imaging method, can effectively evaluate tumor angiogenesis in rabbit peripheral lung cancer.

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