Vertical Transmission of HIV-1 in the Metropolitan Area of Belo Horizonte, Brazil: 2006–2014

Objective To revise HIV-1 vertical transmission (VT) rates in the metropolitan area of Belo Horizonte, Brazil, from January of 2006 to December of 2014. Methods Descriptive study of a prospective cohort of HIV-1-infected pregnant women and their children, monitored by the Maternal and Child HIV/Aids Research Group of Research Group at Faculty of Medicine of Universidade Federal de Minas Gerais, Brazil. Results The VT general rate was 1.9% (13/673; confidence interval [CI] 95%: 1.0–3.3). The extensive use of combined highly active antiretroviral therapy (HAART) (89.7%; 583/650) strongly impacted the reduction of VT during this period. Maternal viral load (VL) higher than 1,000 copies/mL showed significant association with VT (OR:6.6; CI 95%:1.3–33.3). Maternal breastfeeding was described in 10 cases in this cohort (1.5%; CI 95%: 0.7–2.7), but it was not associated with VT. Conclusion The present cohort data were coherent with the low VT rate described in other global populations, and it was considerably lower in comparison to the results of the same cohort during the period of 1998–2005, when the VT rate was 6.2%. These data confirm the efficiency of the National Guidelines, and emphasize the importance of adopting the international recommended procedures for prevention of mother-to-child transmission (MTCT) of HIV.

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Immunological response to highly active antiretroviral therapy following treatment for prevention of mother to child transmission of HIV‐1: a study in Côte d'Ivoire

Journal of the International AIDS Society ◽

10.1186/1758-2652-13-28 ◽

2010 ◽

Vol 13 (1) ◽

pp. 28-28 ◽

Cited By ~ 2

Author(s):

Didier K Ekouevi ◽

Patrick A Coffie ◽

Marie‐Laure Chaix ◽

Besigin Tonwe‐Gold ◽

Clarisse Amani‐Bosse ◽

...

Keyword(s):

Antiretroviral Therapy ◽

Cote D'ivoire ◽

Highly Active Antiretroviral Therapy ◽

Côte D’Ivoire ◽

Immunological Response ◽

Mother To Child Transmission ◽

Child Transmission ◽

Highly Active ◽

Mother To Child ◽

Hiv 1

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Prevention of Mother-to-Child Transmission of HIV-1 Using Highly Active Antiretroviral Therapy in Rural Yunnan, China

JAIDS Journal of Acquired Immune Deficiency Syndromes ◽

10.1097/qai.0b013e3181c7d47b ◽

2010 ◽

Vol 53 ◽

pp. S15-S22 ◽

Cited By ~ 12

Author(s):

Zengquan Zhou ◽

Kathrine Meyers ◽

Xia Li ◽

Qingling Chen ◽

Haoyu Qian ◽

...

Keyword(s):

Antiretroviral Therapy ◽

Highly Active Antiretroviral Therapy ◽

Mother To Child Transmission ◽

Child Transmission ◽

Highly Active ◽

Mother To Child ◽

Hiv 1

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Absence of Detectable HIV-1 Provirus DNA After Early Highly Active Antiretroviral Therapy in Children Infected by Vertical Transmission

JAIDS Journal of Acquired Immune Deficiency Syndromes ◽

10.1097/00126334-200212010-00013 ◽

2002 ◽

Vol 31 (4) ◽

pp. 450-452 ◽

Cited By ~ 2

Author(s):

Carmen Muñoz-Almagro ◽

Claudia Fortuny ◽

Teresa Juncosa ◽

Maria T. Garcia-Fructuoso ◽

A. Gonzalez-Cuevas ◽

...

Keyword(s):

Antiretroviral Therapy ◽

Vertical Transmission ◽

Highly Active Antiretroviral Therapy ◽

Highly Active ◽

Hiv 1

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Fetal outcome of HIV positive pregnant women taking highly active antiretroviral therapy at Yaoundé Central Hospital: a cross sectional analytic study

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20174989 ◽

2017 ◽

Vol 6 (11) ◽

pp. 4791 ◽

Cited By ~ 1

Author(s):

Fouedjio J. H. ◽

Loweh Limyuy Ntani ◽

Fouelifack Ymélé Florent ◽

Mbu Robinson Mbu Robinson Enow

Keyword(s):

Antiretroviral Therapy ◽

Pregnant Women ◽

Vertical Transmission ◽

Highly Active Antiretroviral Therapy ◽

Sub Saharan Africa ◽

Hiv Positive ◽

Cross Sectional ◽

Highly Active ◽

Vertical Transmission Of Hiv ◽

Foetal Outcome

Background: HIV infection in pregnant women is delicate both for the mother and her child. With the adoption of option B+ treatment plan by Cameroon’s ministry of public health, there has been a marked decrease in the vertical transmission of HIV from mothers to their babies. There is a dearth of evidence in sub-Saharan Africa, especially in Cameroon, on the effects of highly active antiretroviral therapy (HAART) on pregnancy and foetal outcomes with respect to the time from onset of treatment. We therefore carried out this study to determine the foetal outcome of women on HAART. We hypothesized that the foetal outcome is poorer for pregnant women starting HAART during pregnancy compared to those starting HAART prior to conception.Methods: We carried out an analytic cross-sectional study which spanned from the 1st February to 30th April 2017 at the Yaoundé Central Maternity. We included consenting hospitalised HIV infected women who just terminated a pregnancy (abortion or delivery), and who started HAART at least four weeks before termination of pregnancy. Data was analysed using EPI info 7.2.1.0. SPSS version 20.0. Odds ratio (OR) was used to assess the degree of association that could exist between qualitative variables. The threshold of statistical significance was set at a p-value of 0.05.Results: A total of 121 participants were recruited in the present study. The mean age of the participants was 31.3±5.3 years for those who started HAART before pregnancy and 29.4±5.5 years for those who started during pregnancy (p=0.07). The viral loads means for those who started taking HAART before pregnancy 34.6±21.5 cells/mm3 and those who started during pregnancy 60±14 cells/mm3 (p = 0.01). Overall there were not any significant adverse fetal outcomes caused by taking HAART before or during pregnancy (p >0.05).Conclusions: Despite the fact that the viral load was more elevated in women starting HAART prior pregnancy compared to those started during pregnancy, there was no significant adverse foetal outcome related to time of initiation of HAART treatment by pregnant HIV positive in Yaoundé central Maternity. We suggest that the implementing of the test and treat strategy will have a positive impact on the vertical transmission of HIV.

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