Das kindliche Hepatoblastom

Dietrich von Schweinitz

doi:10.1055/s-0037-1617801

Das kindliche Hepatoblastom

Kinder- und Jugendmedizin ◽

10.1055/s-0037-1617801 ◽

2003 ◽

Vol 03 (06) ◽

pp. 221-226

Author(s):

Dietrich von Schweinitz

Keyword(s):

Diagnostische Bildgebung ◽

Alpha Fetoprotein ◽

Chirurgische Resektion ◽

Serum Alpha Fetoprotein

ZusammenfassungDas Hepatoblastom (HB) ist ein hoch maligner, embryonaler Lebertumor des frühen Kindesalters. Neben Fieber, tastbarem Oberbauchtumor und Thrombozytose haben 80% der Patienten ein exzessiv erhöhtes Serum-Alpha-Fetoprotein. Die diagnostische Bildgebung beruht auf Sonographie, CT und MRT. Wegen meist gutem Ansprechen sollte das Hepatoblastom in der Regel primär mit Chemotherapie behandelt werden, da danach eine Resektion sicherer und risikoärmer ist. Die wichtigsten Medikamente sind Cisplatin und Doxorubicin. Die Therapie für Standard-Risiko-HB (SR-HB) der GPOH-Studie HB99 enthält Ifosfamid (3 g/m2), Cisplatin (100 mg/m2) und Doxorubicin (60 mg/m2) mit einer Ansprechwahrscheinlichkeit von 95% der Tumoren. Disseminierte und metastasierende Hochrisiko-HB benötigen intensivere Chemotherapie entsprechend den aktuellen kooperativen Studienprotokollen. Voraussetzung für eine Heilung ist die radikale chirurgische Resektion des Tumors, in Einzelfällen auch als Lebertransplantation. Die Gesamtremissionsrate liegt derzeit bei 75%, für SR-HB beträgt sie 90%, für HR-HB jedoch nur 30%.

Download Full-text

Faculty Opinions recommendation of Defining hepatoblastoma responsiveness to induction therapy as measured by tumor volume and serum alpha-fetoprotein kinetics.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.5078969.5016077 ◽

2010 ◽

Author(s):

Piotr Czauderna

Keyword(s):

Induction Therapy ◽

Tumor Volume ◽

Alpha Fetoprotein ◽

Serum Alpha Fetoprotein

Download Full-text

RESULTS OF 12 YEARS' COMBINED MATERNAL SERUM ALPHA-FETOPROTEIN SCREENING AND ULTRASOUND FETAL MONITORING FOR PRENATAL DETECTION OF FETAL MALFORMATIONS IN HAVANA CITY, CUBA

Prenatal Diagnosis ◽

10.1002/(sici)1097-0223(199704)17:4<301::aid-pd969>3.0.co;2-x ◽

1997 ◽

Vol 17 (4) ◽

pp. 301-304 ◽

Cited By ~ 7

Author(s):

L. RODRÍGUEZ ◽

R. SÁNCHEZ ◽

J. HERNÁNDEZ ◽

L. CARRILLO ◽

J. OLIVA ◽

...

Keyword(s):

Fetal Monitoring ◽

Maternal Serum ◽

Alpha Fetoprotein ◽

Prenatal Detection ◽

Fetal Malformations ◽

Serum Alpha Fetoprotein ◽

Havana City

Download Full-text

Evaluation of serum alpha fetoprotein-L3 as an accuracy novel biomarker for the early diagnosis of hepatocellular carcinoma in Egyptian Patients

Saudi Journal of Biological Sciences ◽

10.1016/j.sjbs.2021.06.020 ◽

2021 ◽

Author(s):

Hassnaa Mohamed Ibrahim ◽

Magdy Zaki Elghannam ◽

Om Ali Yousef Elkhawaga ◽

Ahmed Mohamed Adel El-Sokkary

Keyword(s):

Hepatocellular Carcinoma ◽

Early Diagnosis ◽

Alpha Fetoprotein ◽

Egyptian Patients ◽

Serum Alpha Fetoprotein

Download Full-text

Hepatoid adenocarcinoma of the lung and the review of the literature

Journal of Oncology Pharmacy Practice ◽

10.1177/1078155220903360 ◽

2020 ◽

Vol 26 (6) ◽

pp. 1505-1510

Author(s):

Onder Tonyali ◽

Onur Gonullu ◽

Mehmet Akif Ozturk ◽

Aysun Kosif ◽

Ozlenen Gonca Civi

Keyword(s):

Concurrent Chemoradiotherapy ◽

Mediastinal Lymph Node ◽

Alpha Fetoprotein ◽

Disease Stage ◽

Hepatoid Adenocarcinoma ◽

Rare Type ◽

Adenocarcinoma Of The Lung ◽

Female Smoker ◽

Diagnostic Biopsy ◽

Serum Alpha Fetoprotein

Introduction Hepatoid adenocarcinoma of the lung is an extremely rare type of the non-small cell lung cancer. Treatment principles and prognosis are similar to that of lung adenocarcinoma. Case report A 62-year-old female smoker presented with a huge mass in the left upper lobe. After diagnostic biopsy, she underwent left pneumonectomy and mediastinal lymph node dissection. A diagnosis of stage T4N1M0 hepatoid adenocarcinoma of the lung with positive surgical margins was made. Management and outcome After the operation, the level of serum alpha fetoprotein was 9010 ng/ml (N: <10). The level of serum alpha fetoprotein was decreased with concurrent chemoradiotherapy and chemotherapy. Disease progression was detected at 11 months after diagnosis. No response was obtained to other therapies. The patient died at 14 months from the time of diagnosis. Discussion Usually, patients with hepatoid adenocarcinoma of the lung are male smokers. Hepatoid adenocarcinoma tends to settle in the upper lobes of the lung. The most important prognostic factor of the hepatoid adenocarcinoma of the lung is the disease stage at the diagnosis and patients with metastatic disease have poor survival.

Download Full-text