A Comparison of 111In-Labelled Polymer Beads and 99mTc-Sn-Colloid as Solid Food and Semi-Solid Food Tracers for Scintigraphic Gastric Emptying Studies

In order to establish the efficacy of labelling a solid meal and a semi-solid meal with either 111ln-labelled polymer beads or 99mTc-tin colloid beagle dogs were fed variously labelled meals of different consistencies and then monitored by scintigraphy for gastric motility patterns. The labelling with each tracer was either performed by thoroughly mixing it into the food before cooking, or alternatively by surface labelling after the food had been cooked. For the 99mTc-Sn- colloid tracer no difference was found in the measured gastric emptying times resulting from either pre-cooking labelling or surface labelling of the meals. Cooking the tracer together with the ingredients does however seem to promote a firm entrapment of the 111ln-polymer beads into a solid protein, and in this manner the111In-labelled resin appears to be a reliable solid food tracer. Surface labelling with 111ln-polymer beads of a solid meal with a smooth texture fails totally and the tracer empties with the liquid phase.

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The Effect of Glucose or Fructose Added to a Semi-solid Meal on Gastric Emptying Rate, Appetite, and Blood Biochemistry

Frontiers in Nutrition ◽

10.3389/fnut.2018.00094 ◽

2018 ◽

Vol 5 ◽

Cited By ~ 3

Author(s):

Gethin H. Evans ◽

John McLaughlin ◽

Adora M. W. Yau

Keyword(s):

Gastric Emptying ◽

Blood Biochemistry ◽

Solid Meal ◽

Gastric Emptying Rate ◽

Semi Solid ◽

Effect Of Glucose

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Effect of ethyl alcohol on motor function in canine stomach

AJP Gastrointestinal and Liver Physiology ◽

10.1152/ajpgi.1992.262.2.g223 ◽

1992 ◽

Vol 262 (2) ◽

pp. G223-G230

Author(s):

L. C. Knight ◽

A. H. Maurer ◽

R. Wikander ◽

B. Krevsky ◽

L. S. Malmud ◽

...

Keyword(s):

Gastric Emptying ◽

Solid Food ◽

Blood Levels ◽

Lag Phase ◽

Dependent Manner ◽

Solid Meal ◽

The Mean ◽

High Doses ◽

Mean Time ◽

Dose Dependent

The aim of this study was to elucidate the effects of ethanol on gastric emptying and the trituration of solid food. With the use of a noninvasive physiological imaging technique, gastric processing of a radiolabeled solid meal was evaluated in unanesthetized dogs which ingested 6-8% ethanol solutions or received intravenous alcohol before the meal. Oral alcohol (resulting in blood levels up to 174 mg/dl) decreased the amplitude of antral contractions or completely abolished them. Alcohol did not significantly affect the fundamental frequency of contractions except at high doses, at which contractions were abolished. Alcohol lengthened the mean time to 50% of gastric emptying in a dose-dependent manner, from 132 +/- 3 min without alcohol to 160 +/- 10 min with oral alcohol at blood levels of 80-120 mg/dl (P less than 0.05). This was manifested by a lengthening of the lag phase, but there was no effect on the terminal slope of emptying (emptying rate) of the processed meal. At equal blood levels up to 120 mg/dl, orally administered alcohol had a more pronounced effect than intravenous alcohol. These data suggest that even low doses of dilute alcohol affect the ability of the antrum to process solid food and thereby contribute to impairment of gastric emptying.

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Involvement of NO in gastric emptying of semi-solid meal in conscious pigs

Neurogastroenterology & Motility ◽

10.1111/j.1365-2982.2004.00604.x ◽

2005 ◽

Vol 17 (2) ◽

pp. 229-235 ◽

Cited By ~ 10

Author(s):

R. A. Lefebvre ◽

J. M. C. Dick ◽

S. Guerin ◽

C.-H. Malbert

Keyword(s):

Gastric Emptying ◽

Solid Meal ◽

Semi Solid

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Relationships between gastric emptying of solid and caloric liquid meals and alcohol absorption

AJP Gastrointestinal and Liver Physiology ◽

10.1152/ajpgi.1989.257.2.g291 ◽

1989 ◽

Vol 257 (2) ◽

pp. G291-G298 ◽

Cited By ~ 10

Author(s):

M. Horowitz ◽

A. Maddox ◽

M. Bochner ◽

J. Wishart ◽

R. Bratasiuk ◽

...

Keyword(s):

Gastric Emptying ◽

Close Correlation ◽

Solid Food ◽

Lag Phase ◽

Solid Meal ◽

Liquid Meal ◽

The Relationship ◽

Meal Composition

The effects of three variations in meal composition (a solid and a liquid meal consumed together, a liquid meal consumed alone, and a liquid meal consumed 90 min after a solid meal) on the rates and patterns of solid and liquid gastric emptying were examined in 13 volunteers. By including alcohol (0.5 g/kg body wt) in the liquid meal, the relationship between alcohol absorption and gastric emptying was also assessed. The lag phase and the initial emptying phase of the solid meal were prolonged (P less than 0.001) when the liquid meal was consumed with the solid meal, compared with when the liquid meal was consumed 90 min after the solid meal. In this latter situation, consumption of the liquid meal caused the cessation of emptying of solid food, and this second lag phase was followed by a slower (P less than 0.001) than initial emptying phase. Gastric emptying of the liquid meal was slower (P less than 0.005) when solid food was present and was slowest (P less than 0.05) when liquid was consumed 90 min after the solid meal. Alcohol absorption was fastest (P less than 0.05) when the liquid meal was consumed alone and slower (P less than 0.01) when alcohol was consumed with or after the solid meal. For all three meals there was a close correlation (r greater than or equal to 0.91; P less than 0.001) between alcohol absorption and liquid emptying. We conclude that gastric emptying of liquid may be influenced by solid food and that the rate and pattern of solid emptying may be modified by the presence of liquid.(ABSTRACT TRUNCATED AT 250 WORDS)

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Cholinergic effects on human gastric motility

Gut ◽

10.1136/gut.45.3.346 ◽

1999 ◽

Vol 45 (3) ◽

pp. 346-354 ◽

Cited By ~ 71

Author(s):

H P Parkman ◽

D M Trate ◽

L C Knight ◽

K L Brown ◽

A H Maurer ◽

...

Keyword(s):

Gastric Emptying ◽

Gastric Motility ◽

Normal Subjects ◽

Cholinergic Stimulation ◽

Gastric Myoelectrical Activity ◽

Solid Meal ◽

Myoelectrical Activity ◽

Motility Index ◽

Antroduodenal Manometry ◽

Cholinergic Effects

BACKGROUNDCholinergic regulation of chronotropic (frequency) and inotropic (force) aspects of antral contractility and how these impact on gastric emptying are not well delineated.AIMSTo determine the effects of cholinergic stimulation and inhibition on myoelectric, contractile, and emptying parameters of gastric motility.METHODSTen normal subjects underwent three studies each, using simultaneous electrogastrography (EGG), antroduodenal manometry, and gastric emptying with dynamic antral scintigraphy (DAS). After 30 minutes of baseline fasting manometry and EGG, subjects received saline intravenously, atropine (0.6 mg then 0.25 mg/hour intravenously), or bethanechol (5 mg subcutaneously). This was followed by another 30 minutes’ recording and by three hours of postprandial recording after ingestion of a technetium-99m labelled solid meal.RESULTSDuring fasting, atropine decreased, whereas bethanechol increased, the antral manometric motility index and EGG power. Postprandially, atropine decreased the amplitude of antral contractions by DAS, decreased the postprandial antral manometric motility index, and slowed gastric emptying. Atropine caused a slight increase in postprandial frequency of antral contractions by DAS and gastric myoelectrical activity by EGG. Bethanechol slightly increased the amplitude, but slightly decreased the frequency of antral contractions by DAS and decreased the frequency of gastric myoelectrical activity by EGG, with no significant increase in the motility index or gastric emptying.CONCLUSIONSCholinergic antagonism with atropine reduces antral contractility and slows gastric emptying. Cholinergic stimulation with bethanechol increases antral contractility, but decreases the frequency of antral contractions, without altering the antral motility index or gastric emptying.

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