scholarly journals Nonalcoholic Fatty Liver Disease in Children

2018 ◽  
Vol 38 (01) ◽  
pp. 001-013 ◽  
Author(s):  
Jake Mann ◽  
Luca Valenti ◽  
Eleonora Scorletti ◽  
Christopher Byrne ◽  
Valerio Nobili
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Pediatric Population ◽  
Management Strategies ◽  
Diagnostic Tools ◽  
Nonalcoholic Fatty Liver ◽  
Hepatic Diseases ◽  
Early Predictors

AbstractNonalcoholic steatohepatitis, a progressive form of nonalcoholic fatty liver disease (NAFLD), is one of the most common hepatic diseases in children who present with particular risk factors including obesity, sedentary lifestyle, and/or a predisposing genetic background. The worldwide prevalence of NAFLD in children is a worrying phenomenon because this disease is closely associated with the development of both cirrhosis and cardiometabolic syndrome in adulthood. To date, the etiopathogenesis of primary NAFLD in children is unknown. Understanding the pathogenetic mechanisms provides the basis to characterize early predictors of the disease and noninvasive diagnostic tools and to design novel specific treatments and possible management strategies. Despite a few clinical trials on the use of antioxidants combined with lifestyle intervention for NAFLD, no treatment exists for children with NAFLD. In this review, the authors provide an overview of current concepts in epidemiology, histological features, etiopathogenesis, diagnosis, and treatment of NAFLD in pediatric population.

scholarly journals Traditional Chinese Medicine in nonalcoholic fatty liver disease: molecular insights and therapeutic perspectives

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Xianmin Dai ◽  
Jiayi Feng ◽  
Yi Chen ◽  
Si Huang ◽  
Xiaofei Shi ◽  
...  
Keyword(s):  
Liver Disease ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Common Ground ◽  
Nonalcoholic Fatty Liver ◽  
Hepatic Diseases ◽  
Holistic Concept

AbstractNonalcoholic fatty liver disease (NAFLD) has become the world's largest chronic liver disease, while there is still no specific drug to treat NAFLD. Traditional Chinese Medicine (TCM) have been widely used in hepatic diseases for centuries in Asia, and TCM’s holistic concept and differentiation treatment of NAFLD show their advantages in the treatment of this complex metabolic disease. However, the multi-compounds and multi-targets are big obstacle for the study of TCM. Here, we summarize the pharmacological actions of active ingredients from frequently used single herbs in TCM compounds. The combined mechanism of herbs in TCM compounds are further discussed to explore their comprehensive effects on NAFLD. This article aims to summarize multiple functions and find the common ground for TCM treatment on NAFLD, thus providing enrichment to the scientific connotation of TCM theories and promotes the exploration of TCM therapies on NAFLD.

scholarly journals The association between urinary bisphenol A levels and nonalcoholic fatty liver disease in Korean adults: Korean National Environmental Health Survey (KoNEHS) 2015-2017

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Sang Joon An ◽  
Eun-Jung Yang ◽  
Subin Oh ◽  
Kyong Jin Park ◽  
Taehyen Kim ◽  
...  
Keyword(s):  
Liver Disease ◽  
Bisphenol A ◽  
Fatty Liver ◽  
Environmental Health ◽  
Nonalcoholic Fatty Liver Disease ◽  
Health Survey ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver ◽  
Hepatic Diseases ◽  
National Environmental

Abstract Background Nonalcoholic fatty liver disease (NAFLD) is becoming a global health problem. Bisphenol A (BPA), one of most widely used environmental chemicals, is suspected to be a contributor to the development NAFLD. This study was performed to examine the relationship between human BPA levels and risk of NAFLD. Methods The data (n = 3476 adults: 1474 men and 2002 women) used in this study were obtained from the Korean National Environmental Health Survey III (2015-2017). BPA levels were measured in urine samples. NAFLD was defined using hepatic steatosis index after exclusion of other causes of hepatic diseases. Results There was a significant linear relationship between the elevated urinary BPA concentrations and risk of NAFLD. In a univariate analysis, odds ratio (OR) of the highest quartile of urinary BPA level was 1.47 [95% confidence interval (CI) 1.11-1.94] compared to the lowest quartile. After adjusted with covariates, the ORs for NAFLD in the third and fourth quartiles were 1.31 [95% CI 1.03-1.67] and 1.32 [95% CI 1.03–1.70], respectively. Conclusions Urinary BPA levels are positively associated with the risk of NAFLD in adults. Further experimental studies are needed to understand the molecular mechanisms of BPA on NAFLD prevalence.

T1018 Management Strategies Used for Nonalcoholic Fatty Liver Disease: Survey of AASLD Members

2009 ◽  
Vol 136 (5) ◽  
pp. A-847 ◽  
Author(s):  
Anna Patel ◽  
Samer Gawrieh ◽  
Syed Rizvi ◽  
Qun Xiang ◽  
Aniko Szabo ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Management Strategies ◽  
Nonalcoholic Fatty Liver ◽  
Disease Survey
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