Einsatz der FDG-PET bei der Diagnostik des zentralnervösen Lupus erythematodes und Vergleich mit CT und MRI

1989 ◽  
Vol 28 (05) ◽  
pp. 187-192 ◽  
Author(s):  
Gabriele Stoppe ◽  
K. Wildhagen ◽  
G. J. Meyer ◽  
O. Schober
Keyword(s):  
Lupus Erythematosus ◽  
Fdg Pet ◽  
Central Nervous System Involvement ◽  
Special Problem ◽  
Emission Tomography ◽  
Cranial Computed Tomography ◽  
Resonance Imaging ◽  
Positron Emission ◽  
Neuropsychiatric Sle ◽  
Magnetic Resonance Imaging Mri

Central nervous system involvement has been found in 30-75% of all cases of systemic lupus erythematosus (SLE). Up to now, clinical diagnosis is difficult and there are no markers for disease activity. We have compared cranial computed tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography (PET) using fluorodesoxyglucose (FDG) in two cases. FDG-PET is shown to be the most sensitive method demonstrating even reversible deficits and a better correlation with other neurological findings. MRI seems to be more sensitive than CT. A survey of the literature concerning imaging methods in neuropsychiatric SLE is given. The special problem of neuronal desactivation by antineuronal activity is discussed.

scholarly journals Metal-Based Complexes as Pharmaceuticals for Molecular Imaging of the Liver

2019 ◽  
Vol 12 (3) ◽  
pp. 137 ◽  
Author(s):  
Julia Greiser ◽  
Wolfgang Weigand ◽  
Martin Freesmeyer
Keyword(s):  
Magnetic Resonance Imaging ◽  
Positron Emission Tomography ◽  
Metal Complexes ◽  
Imaging Technique ◽  
Imaging Modality ◽  
Emission Tomography ◽  
Resonance Imaging ◽  
Positron Emission ◽  
Magnetic Resonance Imaging Mri ◽  
Uptake Mechanisms

This article reviews the use of metal complexes as contrast agents (CA) and radiopharmaceuticals for the anatomical and functional imaging of the liver. The main focus was on two established imaging modalities: magnetic resonance imaging (MRI) and nuclear medicine, the latter including scintigraphy and positron emission tomography (PET). The review provides an overview on approved pharmaceuticals like Gd-based CA and 99mTc-based radiometal complexes, and also on novel agents such as 68Ga-based PET tracers. Metal complexes are presented by their imaging modality, with subsections focusing on their structure and mode of action. Uptake mechanisms, metabolism, and specificity are presented, in context with advantages and limitations of the diagnostic application and taking into account the respective imaging technique.

Prospective Study of [18F]Fluorodeoxyglucose Positron Emission Tomography and Computed Tomography and Magnetic Resonance Imaging in Oral Cavity Squamous Cell Carcinoma With Palpably Negative Neck

2006 ◽  
Vol 24 (27) ◽  
pp. 4371-4376 ◽  
Author(s):  
Shu-Hang Ng ◽  
Tzu-Chen Yen ◽  
Joseph Tung-Chieh Chang ◽  
Sheng-Chieh Chan ◽  
Sheung-Fat Ko ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Fdg Pet ◽  
Emission Tomography ◽  
Fluorodeoxyglucose Positron Emission Tomography ◽  
Resonance Imaging ◽  
Neck Metastasis ◽  
Positron Emission ◽  
Neck Metastases ◽  
Visual Correlation ◽  
Fluorodeoxyglucose Positron Emission

Purpose To assess the clinical usefulness of [18F]fluorodeoxyglucose positron emission tomography ([18F]FDG PET) as well as computed tomography (CT) or magnetic resonance imaging (MRI) in oral squamous cell carcinoma (SCC) patients with palpably negative neck. Patients and Methods In total, 134 oral SCC patients with palpably negative neck were prospectively evaluated with [18F]FDG PET, CT/MRI, and their visual correlation. Histopathologic analysis was used as the gold standard for assessment of these imaging techniques. Results Thirty-five (26.1%) of our 134 patients were found to have neck metastases. On a level-by-level basis, the sensitivity of [18F]FDG PET for nodal metastases was two-fold higher than that of CT/MRI (41.2% v 21.6%, respectively; P = .021). Visual correlation of [18F]FDG PET and CT/MRI yielded slightly higher sensitivity and specificity than [18F]FDG PET alone (47.1% v 41.2%, P = .25; 98.0% v 96.8%, P = .125, respectively). On a patient-by-patient basis, the sensitivity of [18F]FDG PET for neck metastases was 51.4% and increased to 57.1% after visual correlation with CT/MRI. The probabilities of occult neck metastasis after using [18F]FDG PET were 6.7% in T1 tumors, 10.8% in T2 tumors, 13.3% in T3 tumors, and 25% in T4 tumors and decreased to 3.3% in T1 tumors and to 9.2% in T2 tumors after visual correlation with CT/MRI. Conclusion [18F]FDG PET was superior to CT/MRI for detecting palpably occult neck metastasis of oral SCC. Because [18F]FDG PET could reduce the probability of occult neck metastasis to less than 15% in T1 to T3 tumors, it should be indicated for evaluation of these subpopulations.

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