Prediction of lymph node metastase in NSCLC

2010 ◽  
Vol 01 (05) ◽  
pp. 219-226 ◽  
Author(s):  
F. Beyer ◽  
B. Buerke ◽  
J. Gerss ◽  
K. Scheffe ◽  
M. Puesken ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Fdg Pet ◽  
Automatic Segmentation ◽  
Correlation Coefficients ◽  
Mediastinal Lymph Nodes ◽  
Intra Class Correlation ◽  
Axial Diameter ◽  
Pet Ct ◽  
Fdg Pet Ct

SummaryPurpose: To distinguish between benign and malignant mediastinal lymph nodes in patients with NSCLC by comparing 2D and semiautomated 3D measurements in FDG-PET-CT.Patients, material, methods: FDG-PET-CT was performed in 46 patients prior to therapy. 299 mediastinal lymph-nodes were evaluated independently by two radiologists, both manually and by semi-automatic segmentation software. Longest-axial-diameter (LAD), shortest-axial-diameter (SAD), maximal-3D-diameter, elongation and volume were obtained. FDG-PET-CT and clinical/FDG-PET-CT follow up examinations and/or histology served as the reference standard. Statistical analysis encompassed intra-class-correlation-coefficients and receiver-operator-characteristics-curves (ROC). Results: The standard of reference revealed involvement in 87 (29%) of 299 lymph nodes. Manually and semi-automatically measured 2D parameters (LAD and SAD) showed a good correlation with mean

How to choose PET-CT or CT in the diagnosis and staging of lung cancer

2010 ◽  
Vol 01 (05) ◽  
pp. 213-218
Author(s):  
X. Tao ◽  
H. Liu ◽  
T. Jiang ◽  
X. Zheng ◽  
S. Liu
Keyword(s):  
Lymph Nodes ◽  
Fdg Pet ◽  
Automatic Segmentation ◽  
Correlation Coefficients ◽  
Mediastinal Lymph Nodes ◽  
Intra Class Correlation ◽  
Axial Diameter ◽  
Pet Ct ◽  
Fdg Pet Ct

SummaryPurpose: To distinguish between benign and malignant mediastinal lymph nodes in patients with NSCLC by comparing 2D and semiautomated 3D measurements in FDG-PET-CT. Patients, material, methods: FDG-PET-CT was performed in 46 patients prior to therapy. 299 mediastinal lymph-nodes were evaluated independently by two radiologists, both manually and by semi-automatic segmentation software. Longest-axial-diameter (LAD), shortest-axial-diameter (SAD), maximal-3D-diameter, elongation and volume were obtained. FDG-PET-CT and clinical/FDG-PET-CT follow up examinations and/or histology served as the reference standard. Statistical analysis encompassed intra-class-correlation-coefficients and receiver-operator-characteristics-curves (ROC). Results: The standard of reference revealed involvement in 87 (29%) of 299 lymph nodes. Manually and semi-automatically measured 2D parameters (LAD and SAD) showed a good correlation with mean

scholarly journals Characteristics of Metastatic Mediastinal Lymph Nodes of Non-Small Cell Lung Cancer on Preoperative F-18 FDG PET/CT

2013 ◽  
Vol 48 (1) ◽  
pp. 41-46 ◽  
Author(s):  
Ah Young Lee ◽  
Su Jung Choi ◽  
Kyung Pyo Jung ◽  
Ji Sun Park ◽  
Seok Mo Lee ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Lymph Nodes ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Fdg Pet ◽  
Small Cell ◽  
Mediastinal Lymph Nodes ◽  
Small Cell Lung ◽  
Pet Ct ◽  
Fdg Pet Ct

scholarly journals Evaluation of mediastinal lymph nodes using18F-FDG PET-CT scan and its histopathologic correlation

2011 ◽  
Vol 6 (1) ◽  
pp. 11 ◽  
Author(s):  
Arvind Kumar ◽  
Roman Dutta ◽  
Umashankkar Kannan ◽  
Rakesh Kumar ◽  
GopiChand Khilnani ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Ct Scan ◽  
Fdg Pet ◽  
Mediastinal Lymph Nodes ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Pet Ct Scan

scholarly journals Tubercular Meningitis and Lymphadenitis Mimicking a Relapse of Burkitt's Lymphoma on 18F-FDG-PET/CT: A Case Report

2015 ◽  
Vol 8 (2) ◽  
pp. 226-232 ◽  
Author(s):  
Halima El Omri ◽  
Zsolt Hascsi ◽  
Ruba Taha ◽  
Lajos Szabados ◽  
Hesham El Sabah ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Ct Scan ◽  
Fdg Pet ◽  
Lymph Node Biopsy ◽  
Node Biopsy ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Pet Ct Scan

Tuberculosis (TB) can present with various forms and can occasionally be mistaken for malignancy. Hereby, we report a 53-year-old man diagnosed and treated for Burkitt's lymphoma in 2009 who achieved a complete remission confirmed by a computed tomography (CT) scan. During the follow-up 2 years later, he complained of left hip pain that warranted investigation with magnetic resonance imaging and whole-body 18F-fludeoxyglucose-positron emission tomography (FDG-PET)/CT which showed a benign lesion in the left hip associated with multiple lymph nodes in the chest and abdomen not amenable for biopsy. A follow-up PET/CT scan a few months later showed intense tracer uptake in the lymph nodes with size progression and appearance of new lymph nodes suspicious of lymphoma relapse. The patient was asymptomatic, and all investigations including viral and connective tissue disease studies were negative. Also the tuberculin skin test and QuantiFERON were negative. Lymph node biopsy was planned; however, the patient presented a few days earlier with fever, headache and photophobia. Cerebrospinal fluid (CSF) examination confirmed meningitis with lymphocytic pleocytosis and elevated protein. The CSF Gram stain, culture, viral and acid-fast bacilli were negative. CSF flow cytometry and cytopathology confirmed polyclonal lymphocytosis and suggested reactive causes. CSF TB culture grew Mycobacterium tuberculosis. Mediastinal lymph node biopsy also confirmed TB lymphadenitis. Four antituberculosis drugs were started. One year later, a PET/CT scan showed regression of all the involved lymph nodes. This case highlights the importance of excluding TB in patients with suspected malignancy, especially if they belong to endemic regions, and the increasing role of 18F-FDG-PET/CT in the early detection of extrapulmonary TB.

scholarly journals Lung and Nodal Involvement in Nontuberculous Mycobacterial Disease: PET/CT Role

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Ginevra Del Giudice ◽  
Andrea Bianco ◽  
Antonio Cennamo ◽  
Giulia Santoro ◽  
Marco Bifulco ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Ct Scan ◽  
Fdg Pet ◽  
Lymph Node Involvement ◽  
Mediastinal Lymph Nodes ◽  
Mycobacterial Disease ◽  
Pulmonary Lesions ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Pet Ct Scan

Introduction. Systematic use of18F-FDG PET/CT has the potential to simultaneously assess both pulmonary and lymph node involvement in nontuberculous mycobacterial (NTM) lung infection.Objective. The aim of the study was to evaluate the role of18F-FDG PET/CT in the assessment of both mediastinal lymph nodes and lung involvement in NTM patients compared with active tuberculosis (TB) patients.Methods. 26 patients with pulmonary NTM disease were selected; six consecutive patients had undergone18F-FDG PET/CT and data was compared with 6 active TB patients.Results. NTM exhibited different radiological lung patterns with an average SUV max value at PET/CT scan of 3,59 ± 2,32 (range 1,14 to 9,01) on pulmonary lesions and a mean value of SUV max 1,21 ± 0,29 (range 0,90 to 1,70) on mediastinal lymph nodes. Pulmonary lesions in TB showed an average SUV max value of 10,07 ± 6,45 (range 1,20 to 22,75) whilst involved mediastinal lymph nodes exhibited a mean SUV max value of 7,23 ± 3,03 (range 1,78 to 15,72).Conclusions. The differences in PET uptake in a broad range of lung lesions and lymph nodes between NTM andM. tuberculosispatients suggest a potential role for PET/CT scan in the diagnosis and management of pulmonary mycobacterial disease.

Diagnostic accuracy of FDG PET/CT in mediastinal lymph nodes from lung cancer

2014 ◽  
Vol 83 (8) ◽  
pp. 1301-1302 ◽  
Author(s):  
Valentina Ambrosini ◽  
Stefano Fanti ◽  
Vaseem U. Chengazi ◽  
Domenico Rubello
Keyword(s):  
Lung Cancer ◽  
Lymph Nodes ◽  
Diagnostic Accuracy ◽  
Fdg Pet ◽  
Mediastinal Lymph Nodes ◽  
Pet Ct ◽  
Fdg Pet Ct

scholarly journals False Positive 18F-FDG Uptake in Mediastinal Lymph Nodes Detected with Positron Emission Tomography in Breast Cancer: A Case Report

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Gamze Uğurluer ◽  
Mustafa Kibar ◽  
Sinan Yavuz ◽  
Akin Kuzucu ◽  
Meltem Serin
Keyword(s):  
Breast Cancer ◽  
Positron Emission Tomography ◽  
Lymph Nodes ◽  
Fdg Pet ◽  
Emission Tomography ◽  
Mediastinal Lymph Nodes ◽  
Positron Emission ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

Breast cancer is the most frequently diagnosed cancer among females. It is accepted that lymph node involvement with metastatic tumor and the presence of distant metastasis are the most important prognostic factors. Accurate staging is important in determining prognosis and appropriate treatment. Positron emission tomography with computed tomography detects malignancies using 2-[18F]-fluoro-2-deoxy-d-glucose (18F-FDG PET CT) with high accuracy and they contribute to decisions regarding diagnosis, staging, recurrence, and treatment response. Here, we report a case of false positive metastatic mediastinal lymph nodes that were diagnosed by 18F-FDG PET CT in a 40-year-old breast cancer patient who had undergone preoperative evaluation. Right paratracheal, prevascular, aorticopulmonary, precarinal, subcarinal, hilar, and subhilar multiple conglomerated mediastinal lymph nodes were revealed in addition to left breast mass and axillary lymph nodes. Mediastinoscopy was performed with biopsy and pathology was reported as granulomatous lymphadenitis. In conclusion, any abnormal FDG accumulation in unusual lymph nodes must be evaluated carefully and confirmed histopathologically.

scholarly journals Is SUVmax Helpful in the Differential Diagnosis of Enlarged Mediastinal Lymph Nodes? A Pilot Study

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Congcong Yu ◽  
Xiaotian Xia ◽  
Chunxia Qin ◽  
Xun Sun ◽  
Yongxue Zhang ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Fdg Pet ◽  
Statistical Difference ◽  
Diagnostic Value ◽  
Mediastinal Lymphadenopathy ◽  
Unknown Etiology ◽  
Short Axis ◽  
Mediastinal Lymph Nodes ◽  
Pet Ct ◽  
Fdg Pet Ct

Objective. To explore the diagnostic value of maximum standard uptake value (SUVmax) from 18F-FDG PET/CT images in enlarged mediastinal lymph nodes of unknown etiology. Methods. We performed a retrospective study of patients with enlarged mediastinal lymph nodes on 18F-FDG PET/CT scans. SUVmax and the short axis and long axis of lymph nodes were recorded. These parameters were compared among the five commonest causes of mediastinal lymphadenopathy: lymphoma, metastatic disease, sarcoidosis, tuberculosis, and lymphadenitis. Histopathologic diagnosis was recorded as the final golden standard. Results. A total of 94 patients (62 men and 32 women; age range 7–85 y) were included with final diagnoses of 42 patients with benign pathology and 52 patients with malignancies. The sensitivity, specificity, and the accuracy of PET/CT in diagnosis of the benign and malignant mediastinal lymph nodes were 94.2%, 73.8%, and 85.1%, respectively. The SUVmax of benign and malignant groups were 13.10 ± 5.21 and 12.59 ± 5.50, respectively, which had no statistical difference (P>0.05). However, the long axis and the short axis of lymph nodes in the benign and malignant groups were 2.86 ± 1.02 cm, 1.77 ± 0.60 cm and 6.04 ± 3.83 cm, 3.95 ± 2.08 cm, respectively (P<0.05). The diagnostic values of PET/CT were higher than those of the long or short axis. However, the specificity of PET/CT was lower (73.8%) than that from the long or short axis (90.5% and 92.9%, respectively), although no statistical difference existed. Among the five common causes of mediastinal lymphadenopathy, significant differences could be seen in SUVmax and in the long axis and the short axis of lymph nodes (P<0.05). Conclusions. SUVmax, a commonly used semiquantitative measurement, was not helpful for differentiation between benign and malignant lesions in patients with enlarged mediastinal lymph nodes in this study. Many benign lesions, such as sarcoidosis and tuberculosis, had high FDG uptake, possibly a trend that the size of the lymph nodes seems to have some diagnostic value.

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