The Young Platelet Population in Children with Cyanotic Congenital Heart Disease

1976 ◽  
Vol 35 (02) ◽  
pp. 342-349 ◽  
Author(s):  
Béla Goldschmidt ◽  
Svein Jan Sørland
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Protein Content ◽  
Size Distribution ◽  
Congenital Heart ◽  
Initial Rate ◽  
Cyanotic Congenital Heart Disease ◽  
Normal Platelet ◽  
Platelet Size ◽  
The Mean

SummarySome morphological, biochemical and functional parameters of platelet population in children with cyanotic congenital heart disease (CCHD) were studied by making comparisons of the normal platelet population in both CCHD patients and controls. The mean volume of the platelets from cyanotic patients was greater than from normals. The platelet size distribution curves demonstrated a shift towards larger than normal size in the case of CCHD. The mean protein content, as well as the mean PF3 content of platelets was increased in CCHD. Following addition of kaolin, PF3 release was more rapid and of shorter duration with platelets from CCHD patients as compared to normal platelets. They also released more PF3 than did normal platelets. After addition of ADP, collagen, or adrenalin, platelets of CCHD patients were more responsive than similarly treated platelets from normals. Platelets from CCHD showed an increased initial rate of aggregation and greater maximum aggregation. These data suggested that the platelet population of CCHD patients consists of larger, younger and functionally more active platelets than does the platelet population of normals.

Endothelial function state following repair of cyanotic congenital heart diseases

2013 ◽  
Vol 25 (2) ◽  
pp. 222-227 ◽  
Author(s):  
Mohammad Reza Sabri ◽  
Hooman Daryoushi ◽  
Mojgan Gharipour
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Endothelial Function ◽  
Tetralogy Of Fallot ◽  
Congenital Heart ◽  
Cyanotic Congenital Heart Disease ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Flow Mediated Dilatation ◽  
The Mean

AbstractBackgroundRepairing cyanotic congenital heart disease may be associated with preserving endothelial function. The present study aimed to evaluate vascular endothelial function in patients with repaired cyanotic congenital heart disease.MethodsIn a case–control study conducted in 2012 in Isfahan, Iran, 42 consecutive patients aged <35 years who had suffered from different types of cyanotic congenital heart disease and had undergone complete repair of their congenital heart defect were assessed in regard to their endothelial function state by measuring flow-mediated dilatation and other cardiac function indices. They were paired with 42 sex- and age-matched healthy controls.ResultsThe mean flow-mediated dilatation was lower in patients with repaired cyanotic congenital heart disease than in the controls [6.14±2.78 versus 8.16±1.49 respectively (p<0.001)]. Significant adverse correlations were found between flow-mediated dilatation, age, and body mass indexes, in those who underwent repair surgery. In addition, flow-mediated dilatation had a positive association with the shortening fraction, ejection fraction, and tricuspid annular plane systolic excursion value, and it was also inversely associated with carotid intima-media thickness and the myocardial performance index. The mean of the flow-mediated dilatation was significantly higher in the group with tetralogy of Fallot along with complete repair before the age of 2.5 years and also in those patients with total anomalous pulmonary venous connection or transposition of the great arteries repaired with an arterial switch operation before 6 months of age, compared with the other two subgroups. This includes patients with a tetralogy of Fallot defect repaired after 4 years of age and those with complex cyanotic congenital heart disease that was repaired after 2.5 years of age (mean age at repair 9±6.1 years).ConclusionEarly repair of a cyanotic defect can result in the protection of vascular endothelial function and prevent the occurrence of vascular accidents at an older age.

scholarly journals BRAIN ABSCESS;

2012 ◽  
Vol 20 (01) ◽  
pp. 030-033
Author(s):  
MUBARAK ALORAIJ
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Brain Abscess ◽  
Congenital Heart ◽  
Cyanotic Congenital Heart Disease ◽  
Neurological Deficits ◽  
High Morbidity ◽  
Sources Of Infection ◽  
The Mean ◽  
The Brain

Objective: To evaluate the clinical presentation, diagnosis, sources of infection, surgical management outcome andmicroorganisms involved in the brain abscess in our locality. Period & Setting: This study was carried out in the department ofNeurosurgery, Aseer Central Hospital Abha, Southern Province, KSA from 1426 H – 1433 H (2005-2012 AD). Material and Methods: Atotal of 30 children aged less than 15 years were reviewed. There were 15 males and 15 females. The mean age of presentation was5.6±4.4 years. Results: Typically patients presented with fever, vomiting, headache and seizures. The predisposing conditions foundwere cyanotic congenital heart disease in 11 (37%) of children, meningitis in 6 (20%), septicemia in 7 (23%) and no underlying causewas found in 5 (17%) children. The most common microbe in children with cyanotic congenital heart disease was of the Streptococcusmilleri group (52%). All abscesses were large, more than 2 cm in diameter and were aspirated surgically. Excision was performed in 6children. Five children expired, one due to a intracranial bleeding and the others due to severe cerebral edema and tentorial herniation.Complications were seen in 20 children and 16 had sequelae, hemiparesis in 11 and seizure disorder in 5. Conclusions: It is concludedfrom the study that delayed surgical drainage has high morbidity and mortality. Diagnosis with CT scan, appropriate antibiotic therapy andcomplete aspiration of abscess reduced the mortality and neurological deficits from brain abscess.

scholarly journals Development of nephropathy in an adult patient after Fontan palliation for cyanotic congenital heart disease

2021 ◽  
Author(s):  
Kaori Hayashi ◽  
Akinori Hashiguchi ◽  
Masako Ikemiyagi ◽  
Hirobumi Tokuyama ◽  
Shu Wakino ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Adult Patient ◽  
Congenital Heart ◽  
Cyanotic Congenital Heart Disease ◽  
Fontan Palliation

scholarly journals A novel haemoglobin variant mimicking cyanotic congenital heart disease

2016 ◽  
pp. bcr2015213615
Author(s):  
Francisco Abecasis ◽  
Inês Marques ◽  
Celeste Bento ◽  
Anabela Ferrão
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Cyanotic Congenital Heart Disease ◽  
Haemoglobin Variant

Extracorporeal membrane oxygenation and cyanotic congenital heart disease

1992 ◽  
Vol 2 (4) ◽  
pp. 359-360 ◽  
Author(s):  
Gale A. Pearson ◽  
Richard K. Firmin ◽  
Ranjit Leanage
Keyword(s):  
Congenital Heart Disease ◽  
United Kingdom ◽  
Heart Disease ◽  
Extracorporeal Membrane Oxygenation ◽  
Congenital Heart ◽  
Cyanotic Congenital Heart Disease ◽  
Membrane Oxygenation ◽  
The United Kingdom

AbstractWorldwide figures suggest that two percent of appropriate referrals for neonatal extracorporeal membrane oxygenation turn out to have previously covert congenital heart disease. This is despite the fact that expert cardiological evaluation is routine prior to cannulation. The experience in the United Kingdom includes such a case which is reported here. The implications for the role of pediatric cardiologists in such a service are considered.

Sign in / Sign up

Export Citation Format

Share Document