The Effect of Halofenate or Halofenate Free Acid on Human, Rat and Guinea Pig Platelet Aggregation
1976 ◽
Vol 35
(02)
◽
pp. 358-363
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Keyword(s):
SummaryHalofenate free acid (HFA), the major metabolite of the hypolipemic agent halofenate, blocked the secondary phase of human platelet aggregation induced by ADP, epinephrine, or thrombin; higher concentrations of clohbrate free acid (CFA) were required to produce similar inhibitory effects on platelet aggregation. HFA and CFA inhibited collagen-induced aggregation of human, rat, or guinea pig platelets. Halofenate orally administered to rats caused inhibition of collagen-induced aggregation when plasma levels of HFA exceeded 300 μg/ml, a clinically achievable human plasma concentration. The platelet inhibitory effects of clofibrate administration were less than those observed with halofenate administration.
1982 ◽
Vol 48
(02)
◽
pp. 162-165
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1971 ◽
Vol 49
(5)
◽
pp. 479-481
◽
2013 ◽
Vol 10
(1)
◽
1981 ◽
1973 ◽
Vol 29
(01)
◽
pp. 190-195
◽
1987 ◽