Fibrinolysis in Grafted Arteries and Veins

1978 ◽  
Vol 40 (02) ◽  
pp. 512-517 ◽  
Author(s):  
Bo Risberg
Keyword(s):  
Plasminogen Activator ◽  
Fibrinolytic Activity ◽  
Vessel Wall ◽  
Observation Time ◽  
Caval Vein ◽  
Vein Grafts ◽  
Aortic Segment ◽  
Plasminogen Activator Activity ◽  
Arteries And Veins

SummaryThe fibrinolytic activity in autologous artery and vein grafts was studied in cats during a 4-month period. The fibrinolytic activity in the wall of an aortic segment interposed in the caval vein was increased in comparison to the normal aorta. In the corresponding segment of the caval vein interposed in the aorta, the fibrinolytic activity was reduced during the observation time. Thrombosed segments had a decreased activity. No changes were seen in sham operated animals. The plasminogen activator activity in the vessel wall was found to be influenced by the surrounding milieu.

The Plasminogen Activator of the Arterial Wall

1977 ◽  
Vol 37 (03) ◽  
pp. 436-443 ◽  
Author(s):  
L Donner ◽  
P Klener ◽  
Z Roth
Keyword(s):  
Alkaline Phosphatase ◽  
Plasminogen Activator ◽  
Abdominal Aorta ◽  
Fibrinolytic Activity ◽  
Vessel Wall ◽  
Arterial Wall ◽  
Potassium Thiocyanate ◽  
Post Mortem ◽  
Plasminogen Activator Activity ◽  
Human Arteries

SummaryThe plasminogen activator in 645 specimens of various human arteries – thoracic, abdominal aorta, carotic, pulmonary, renal, basilar, coronary – was studied using Todd’s histochemi-cal method. 92 cadavers were used, 1–18 hours post mortem from subjects aged from 272 days to 83 years. 45 specimens of pulmonary, renal and splenic arteries were obtained during surgery.The greatest fibrinolytic activity was within the adventitia. Intima occasionally showed very little fibrinolytic activity, or none at all.No statistically significant differences in plasminogen activator activity were found between the various arteries examined.A statistically significant increase in fibrinolysis in adventitia of atherosclerotic arteries was established. No correlation was found between the fibrinolytic activity of the arteries and their alkaline phosphatase content.Some properties of the plasminogen activator of the arterial vessel wall were evaluated. Influence of storage, inactivation with epsilonaminocaproic acid and extracted with potassium thiocyanate was studied.

scholarly journals The Lysis of Early Fibrin by Eosinophils

1977 ◽  
Author(s):  
Hau C. Kwaan ◽  
Ali A. Hatem
Keyword(s):  
Plasminogen Activator ◽  
Fibrinolytic Activity ◽  
Cell Membranes ◽  
Red Cell ◽  
Platelet Thrombus ◽  
Platelet Aggregates ◽  
Platelet Thrombi ◽  
Arteries And Veins ◽  
Morphologic Changes

This study examins the role of leukocytes within a thrombus by demonstrating the morphologic detail of their activities, the chemotactic properties of thrombi and the presence of plasminogen and possible plasminogen activator within eosinophils. A model which produces discrete, reproducible platelet thrombi in arteries and veins of dogs allowed timed studies of their early evolution. In this model, the growth of the thrombus was constantly monitored by a flowmeter and the thrombus could thus be removed at a selected period in its formation. It was then studied histologically for fibrin activity and also ultrastructually. Little fibrinolytic activity was found. In contrast to neutrophils which are concerned particularly with the phagocytosis and disruption of platelet aggregates, we observed that eosinophils participate in the lysis and disruption of the fibrin within these aggregates. The fibrin is rarely phagocytosed but is acted on at the surfaces of the eosinophils, usually in shallow invaginations of the cell membranes. The fibrin shows morphologic changes of lysis. It appears that eosinophils and neutrophils are concerned with the transformation of the early fibrin and platelet thrombus, rather than with the resolution of the formed, mainly fibrin and red cell thrombus.

Effect of Ethyloestrenol on Fibrinolysis in the Vessel Wall

1975 ◽  
Author(s):  
U. Hedner ◽  
I. M. Nilsson ◽  
S. Isacson
Keyword(s):  
Side Effects ◽  
Venous Thrombosis ◽  
Plasminogen Activator ◽  
Fibrinolytic Activity ◽  
Vessel Wall ◽  
Marked Decrease ◽  
Venous Occlusion

It has been shown that phenformin plus ethyloestrenol causes a significant increase in the fibrinolytic activity of the vessel wall in most patients with recurrent idiopathic venous thrombosis and with an initially low fibrinolytic activity in the vein walls. At the same time a marked decrease in the frequency of thrombotic episodes occurred (Nilsson et al. 1974). Due to side effects of phenformin attempts have been made to administrate ethyloestrenol alone to patients with an abnormally low plasminogen activator content of the vessel wall and/or a decreased capacity to release plasminogen activator from the vein walls on venous occlusion of the arms. Ethyloestrenol in a dose of 8 mg/d has been given to 34 patients for 3 to 6 months and to 6 patients for 12 months. Ethyloestrenol caused a significant increase in the fibrinolytic activity in 30 of the 34 patients treated for 3-6 months and in 5 of those 6 treated for 12 months. Ethyloestrenol in a dose of 4 mg/d had no effect.

scholarly journals Anticoagulant and fibrinolytic blood systems in patients with arterial hypertension stage III

2014 ◽  
Vol 95 (5) ◽  
pp. 621-625
Author(s):  
G Kh Mirsaeva ◽  
R A Khakimova
Keyword(s):  
Arterial Hypertension ◽  
Plasminogen Activator ◽  
Tissue Plasminogen Activator ◽  
Fibrinolytic Activity ◽  
Hemorrhagic Stroke ◽  
Antithrombin Iii ◽  
Stage Iii ◽  
Cerebral Stroke ◽  
Plasminogen Activator Activity ◽  
Tissue Plasminogen

Aim. To measure the indicators of the anticoagulant and fibrinolytic blood systems activity in patients with arterial hypertension after suffering a hemorrhagic stroke. Methods. 82 patients with arterial hypertension were examined at different terms after suffering a hemorrhagic stroke. Antithrombin III activity, total blood fibrinolytic activity and D-dimer levels, as well as tissue plasminogen activator activity and antigen levels were studied. Patients were examined at admission before standard treatment initiation and at discharge. Tissue plasminogen activator activity and its antigen level were determined at admission. Statistical data processing was performed using Statistica 8 (StatSoft) integrated package for Windows. Results. Inhibited fibrinolytic activity and an imbalance of its components, as well as reduced levels and activity of antithrombin III and signs of fibrin formation were revealed in patients with arterial hypertension stage III at different periods after suffering hemorrhagic stroke. Changes were most evident in early and late recovery periods after suffered cerebral stroke. Subsequent follow-up for over-a-year term after suffered cerebral stroke revealed a trend for normalization of these indicators. The study of tissue plasminogen activator activity and levels of its antigen showed significant changes in these parameters. Analysis of the obtained results for all patients with hypertension, regardless of the period of hemorrhagic stroke, showed the reduction of the antigen tissue plasminogen activator level and its increased activity. After in-patient treatment, there was a trend for improvement in all studied parameters without their complete normalization. Conclusion. The results suggest an activation of intravascular clotting in parients with arterial hypertension who suffered a hemorrhagic stroke, increasing the risk for further cardiovascular complications.

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