Prothrombin-Activator (Thromboplastin) Generation in the Blood of Water Snake (Natrix piscator)

SummaryThe generation of prothrombin-activator (thromboplastin) in water snake (Natrix piscator) is clearly delayed, Compared to a mammalian system, but the final activity is well comparable to that in man, when homologous sources of “phospholipid” (erythrocyte-lysate) and of substrate plasma are employed in one stage “thromboplastin generation test”. The use of heterologous source of either of the above reagents resulted in significantly longer clotting times; hence the need for homologous source of above reagents in the test is emphasized for comparative studies on animal haemostasis.

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Studies on the Participation of Hageman Factor in Fibrinolysis

Thrombosis and Haemostasis ◽

10.1055/s-0038-1654204 ◽

1970 ◽

Vol 24 (01/02) ◽

pp. 001-009 ◽

Cited By ~ 1

Author(s):

R.P McDonagh ◽

J.H Ferguson

Keyword(s):

Cytochrome C ◽

Plasminogen Activator ◽

Specific Inhibition ◽

Hageman Factor ◽

One Stage ◽

Marked Inhibition ◽

Normal Plasma ◽

Generation Test

SummaryThe specific inhibition of the kaolin-mediated Hageman factor activation by the polycations : lysozyme, spermine tetrahydrochloride, and cytochrome c was confirmed. These polycations were without any antiplasmin or antiplasminogen-activator activity when tested in a one-stage lysis system. However, marked inhibition of plasminogen-activator generation in normal plasma by these polycations was noted in the activator-generation test. The proposed role of Hageman factor as that of a lysokinase or indirect activator of plasminogen is supported by these experiments.

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High re-revision rate following one-stage exchange for streptococcal periprosthetic joint infection of the hip

Hip International ◽

10.1177/1120700021991467 ◽

2021 ◽

pp. 112070002199146

Author(s):

Malte Ohlmeier ◽

Insa Jachczik ◽

Mustafa Citak ◽

Thorsten Gehrke ◽

Nael Hawi ◽

...

Keyword(s):

Postoperative Complications ◽

Periprosthetic Joint Infection ◽

Comparative Studies ◽

Streptococcal Infection ◽

Revision Rate ◽

Joint Infection ◽

Harris Hip Score ◽

One Stage ◽

The Mean

Introduction: This study was undertaken to analyse the outcome of 1-stage exchange in the management of streptococcal periprosthetic joint infection (PJI) of the hip at a single hospital. Methods: We identified 30 patients with a streptococcal PJI of the hip who had been treated by 1-stage exchange at our hospital between 2002 and 2017. Postoperative complications and the need for any subsequent re-revision for infection or other reasons were analysed. The Harris Hip Score (HHS) was evaluated at final follow-up. Results: The mean follow-up was 8.2 years (SD 4.1). The overall re-revision rate for any reason was 53% (16/30) at a mean 5.3 years (SD 0.68 years). Re-revision for infection was 20% (6/30) at a mean 1.8 years (SD 0.74 years). All re-revisions for PJI (6/6; 100%) were for relapse of the streptococcal infection. At final follow-up, the mean HHS was 68 points (SD 20). Conclusions: The rate of re-revision after 1-stage exchange for streptococcal PJI is high. Eradication of a streptococcal PJI of the hip remains challenging. Further extensive and comparative studies between 1-and 2-stage exchange are encouraged.

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Factor VII Deficiency in the Beagle Dog

Laboratory Animals ◽

10.1258/002367768781082942 ◽

1968 ◽

Vol 2 (2) ◽

pp. 105-112 ◽

Cited By ~ 10

Author(s):

K. Capel-Edwards ◽

O. E. Hall

Keyword(s):

Blood Coagulation ◽

Factor Vii ◽

Blood Coagulation Disorders ◽

Coagulation Disorders ◽

Beagle Dog ◽

Physical Evidence ◽

Factor Vii Deficiency ◽

One Stage ◽

Healthy Female ◽

Generation Test

Two cases are described of factor VII deficiency in the blood of healthy female beagles. The diagnosis was established on the basis of: (i) prolonged Quick's one-stage prothrombin and ‘Thrombotest’ times, both corrected by the addition of 10 per cent by volume of normal canine serum; (ii) normal Russell's viper venom time and thromboplastin generation test; and (iii) reduced factor VII activity compared with plasma from a normal dog. Attention is drawn to some implications of inherited blood-coagulation disorders not associated with physical evidence of bleeding.

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The Prephase Accelerator. Present Status

Thrombosis and Haemostasis ◽

10.1055/s-0038-1654558 ◽

1961 ◽

Vol 6 (02) ◽

pp. 254-260 ◽

Cited By ~ 2

Author(s):

F Duckert

Keyword(s):

Present Status ◽

Factor Ix ◽

Quantitative Assay ◽

Assay Method ◽

Clotting Factors ◽

Haemophilia B ◽

Hageman Factor ◽

One Stage ◽

The One ◽

Generation Test

SummaryThe properties of the prephase accelerator (PPA) are indicated as well as its differentiation from other known clotting factors. PPA is either a reaction product or a degratation product. For its normal formation genuine factor IX, PTA and ? Hageman factor are necessary.The one-stage quantitative assay method for factor “IX” does not determine the factor lacking in haemophilia B. This method gives a measure of PPA.Some practical observations are made concerning the value of the one-stage assay method for factor “IX” and of the thromboplastin generation test for the diagnosis of haemophilia B.

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A “New” Family with Stuart-Prower Deficiency

Thrombosis and Haemostasis ◽

10.1055/s-0038-1654370 ◽

1959 ◽

Vol 03 (01) ◽

pp. 059-076 ◽

Cited By ~ 5

Author(s):

J Roos ◽

C van Arkel ◽

M. C Verloop ◽

F. L. J Jordan

Keyword(s):

Normal Serum ◽

One Stage ◽

New Family ◽

Haemorrhagic Diathesis ◽

Generation Test ◽

Mode Of Inheritance

SummaryA description is given of the coagulation disturbances in six patients with a haemorrhagic diathesis due to Stuart-Prower deficiency. Relatives of these patients, if heterozygous for this deficiency, showed no significant haemorrhagic diathesis; in the laboratory, their one-stage “prothrombin” times showed only a slight prolongation. Thromboplastin formation in these relatives was sufficient, but determination of the Stuart-Prower factor revealed lower values. The relatives in question were incapable of giving the same correction of the thromboplastin generation test in their bleeder relatives as normal serum does.The relation between Stuart-Prower deficiency and Christmas factor is discussed.One patient is described who combined heterozygotism for Stuart-Prower deficiency with alcaptonuria.The mode of inheritance of the Stuart-Prower deficiency is discussed.

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